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In ophthalmology, intravitreal operative medication therapy (IVOM) is a widespread treatment for diseases related to the age-related macular degeneration (AMD), the diabetic macular edema (DME), as well as the retinal vein occlusion (RVO). However, in real-world settings, patients often suffer from loss of vision on time scales of years despite therapy, whereas the prediction of the visual acuity (VA) and the earliest possible detection of deterioration under real-life conditions is challenging due to heterogeneous and incomplete data. In this contribution, we present a workflow for the development of a research-compatible data corpus fusing different IT systems of the department of ophthalmology of a German maximum care hospital. The extensive data corpus allows predictive statements of the expected progression of a patient and his or her VA in each of the three diseases. We found out for the disease AMD a significant deterioration of the visual acuity over time. Within our proposed multistage system, we classify the VA progression into the three groups of therapy "winners", "stabilizers", and "losers" (WSL scheme). Our OCT biomarker classification using an ensemble of deep neural networks results in a classification accuracy (F1-score) of over 98 %, enabling us to complete incomplete OCT documentations while allowing us to exploit them for a more precise VA modelling process. Our VA prediction requires at least four VA examinations and optionally OCT biomarkers from the same time period to predict the VA progression within a forecasted time frame, whereas our prediction is currently restricted to IVOM / no therapy. While achieving a prediction accuracy of up to 69 % (macro average F1-score) when considering all three WSL-based progression groups, this corresponds to an improvement by 11.2 % in comparison to our ophthalmic expertise (57.8 %).

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In the field of cybersecurity, the ability to compute similarity scores at the function level is import. Considering that a single binary file may contain an extensive amount of functions, an effective learning framework must exhibit both high accuracy and efficiency when handling substantial volumes of data. Nonetheless, conventional methods encounter several limitations. Firstly, accurately annotating different pairs of functions with appropriate labels poses a significant challenge, thereby making it difficult to employ supervised learning methods without risk of overtraining on erroneous labels. Secondly, while SOTA models often rely on pre-trained encoders or fine-grained graph comparison techniques, these approaches suffer from drawbacks related to time and memory consumption. Thirdly, the momentum update algorithm utilized in graph-based contrastive learning models can result in information leakage. Surprisingly, none of the existing articles address this issue. This research focuses on addressing the challenges associated with large-scale BCSD. To overcome the aforementioned problems, we propose GraphMoco: a graph momentum contrast model that leverages multimodal structural information for efficient binary function representation learning on a large scale. Our approach employs a CNN-based model and departs from the usage of memory-intensive pre-trained models. We adopt an unsupervised learning strategy that effectively use the intrinsic structural information present in the binary code. Our approach eliminates the need for manual labeling of similar or dissimilar information.Importantly, GraphMoco demonstrates exceptional performance in terms of both efficiency and accuracy when operating on extensive datasets. Our experimental results indicate that our method surpasses the current SOTA approaches in terms of accuracy.

We investigate the ability of individuals to visually validate statistical models in terms of their fit to the data. While visual model estimation has been studied extensively, visual model validation remains under-investigated. It is unknown how well people are able to visually validate models, and how their performance compares to visual and computational estimation. As a starting point, we conducted a study across two populations (crowdsourced and volunteers). Participants had to both visually estimate (i.e, draw) and visually validate (i.e., accept or reject) the frequently studied model of averages. Across both populations, the level of accuracy of the models that were considered valid was lower than the accuracy of the estimated models. We find that participants' validation and estimation were unbiased. Moreover, their natural critical point between accepting and rejecting a given mean value is close to the boundary of its 95% confidence interval, indicating that the visually perceived confidence interval corresponds to a common statistical standard. Our work contributes to the understanding of visual model validation and opens new research opportunities.

The online emergence of multi-modal sharing platforms (eg, TikTok, Youtube) is powering personalized recommender systems to incorporate various modalities (eg, visual, textual and acoustic) into the latent user representations. While existing works on multi-modal recommendation exploit multimedia content features in enhancing item embeddings, their model representation capability is limited by heavy label reliance and weak robustness on sparse user behavior data. Inspired by the recent progress of self-supervised learning in alleviating label scarcity issue, we explore deriving self-supervision signals with effectively learning of modality-aware user preference and cross-modal dependencies. To this end, we propose a new Multi-Modal Self-Supervised Learning (MMSSL) method which tackles two key challenges. Specifically, to characterize the inter-dependency between the user-item collaborative view and item multi-modal semantic view, we design a modality-aware interactive structure learning paradigm via adversarial perturbations for data augmentation. In addition, to capture the effects that user's modality-aware interaction pattern would interweave with each other, a cross-modal contrastive learning approach is introduced to jointly preserve the inter-modal semantic commonality and user preference diversity. Experiments on real-world datasets verify the superiority of our method in offering great potential for multimedia recommendation over various state-of-the-art baselines. The implementation is released at: //github.com/HKUDS/MMSSL.

Autism, also known as Autism Spectrum Disorder (or ASD), is a neurological disorder. Its main symptoms include difficulty in (verbal and/or non-verbal) communication, and rigid/repetitive behavior. These symptoms are often indistinguishable from a normal (control) individual, due to which this disorder remains undiagnosed in early childhood leading to delayed treatment. Since the learning curve is steep during the initial age, an early diagnosis of autism could allow to take adequate interventions at the right time, which might positively affect the growth of an autistic child. Further, the traditional methods of autism diagnosis require multiple visits to a specialized psychiatrist, however this process can be time-consuming. In this paper, we present a learning based approach to automate autism diagnosis using simple and small action video clips of subjects. This task is particularly challenging because the amount of annotated data available is small, and the variations among samples from the two categories (ASD and control) are generally indistinguishable. This is also evident from poor performance of a binary classifier learned using the cross-entropy loss on top of a baseline encoder. To address this, we adopt contrastive feature learning in both self supervised and supervised learning frameworks, and show that these can lead to a significant increase in the prediction accuracy of a binary classifier on this task. We further validate this by conducting thorough experimental analyses under different set-ups on two publicly available datasets.

The Click-Through Rate (CTR) prediction task is critical in industrial recommender systems, where models are usually deployed on dynamic streaming data in practical applications. Such streaming data in real-world recommender systems face many challenges, such as distribution shift, temporal non-stationarity, and systematic biases, which bring difficulties to the training and utilizing of recommendation models. However, most existing studies approach the CTR prediction as a classification task on static datasets, assuming that the train and test sets are independent and identically distributed (a.k.a, i.i.d. assumption). To bridge this gap, we formulate the CTR prediction problem in streaming scenarios as a Streaming CTR Prediction task. Accordingly, we propose dedicated benchmark settings and metrics to evaluate and analyze the performance of the models in streaming data. To better understand the differences compared to traditional CTR prediction tasks, we delve into the factors that may affect the model performance, such as parameter scale, normalization, regularization, etc. The results reveal the existence of the ''streaming learning dilemma'', whereby the same factor may have different effects on model performance in the static and streaming scenarios. Based on the findings, we propose two simple but inspiring methods (i.e., tuning key parameters and exemplar replay) that significantly improve the effectiveness of the CTR models in the new streaming scenario. We hope our work will inspire further research on streaming CTR prediction and help improve the robustness and adaptability of recommender systems.

Breaking safety constraints in control systems can lead to potential risks, resulting in unexpected costs or catastrophic damage. Nevertheless, uncertainty is ubiquitous, even among similar tasks. In this paper, we develop a novel adaptive safe control framework that integrates meta learning, Bayesian models, and control barrier function (CBF) method. Specifically, with the help of CBF method, we learn the inherent and external uncertainties by a unified adaptive Bayesian linear regression (ABLR) model, which consists of a forward neural network (NN) and a Bayesian output layer. Meta learning techniques are leveraged to pre-train the NN weights and priors of the ABLR model using data collected from historical similar tasks. For a new control task, we refine the meta-learned models using a few samples, and introduce pessimistic confidence bounds into CBF constraints to ensure safe control. Moreover, we provide theoretical criteria to guarantee probabilistic safety during the control processes. To validate our approach, we conduct comparative experiments in various obstacle avoidance scenarios. The results demonstrate that our algorithm significantly improves the Bayesian model-based CBF method, and is capable for efficient safe exploration even with multiple uncertain constraints.

Learning on big data brings success for artificial intelligence (AI), but the annotation and training costs are expensive. In future, learning on small data is one of the ultimate purposes of AI, which requires machines to recognize objectives and scenarios relying on small data as humans. A series of machine learning models is going on this way such as active learning, few-shot learning, deep clustering. However, there are few theoretical guarantees for their generalization performance. Moreover, most of their settings are passive, that is, the label distribution is explicitly controlled by one specified sampling scenario. This survey follows the agnostic active sampling under a PAC (Probably Approximately Correct) framework to analyze the generalization error and label complexity of learning on small data using a supervised and unsupervised fashion. With these theoretical analyses, we categorize the small data learning models from two geometric perspectives: the Euclidean and non-Euclidean (hyperbolic) mean representation, where their optimization solutions are also presented and discussed. Later, some potential learning scenarios that may benefit from small data learning are then summarized, and their potential learning scenarios are also analyzed. Finally, some challenging applications such as computer vision, natural language processing that may benefit from learning on small data are also surveyed.

The adaptive processing of structured data is a long-standing research topic in machine learning that investigates how to automatically learn a mapping from a structured input to outputs of various nature. Recently, there has been an increasing interest in the adaptive processing of graphs, which led to the development of different neural network-based methodologies. In this thesis, we take a different route and develop a Bayesian Deep Learning framework for graph learning. The dissertation begins with a review of the principles over which most of the methods in the field are built, followed by a study on graph classification reproducibility issues. We then proceed to bridge the basic ideas of deep learning for graphs with the Bayesian world, by building our deep architectures in an incremental fashion. This framework allows us to consider graphs with discrete and continuous edge features, producing unsupervised embeddings rich enough to reach the state of the art on several classification tasks. Our approach is also amenable to a Bayesian nonparametric extension that automatizes the choice of almost all model's hyper-parameters. Two real-world applications demonstrate the efficacy of deep learning for graphs. The first concerns the prediction of information-theoretic quantities for molecular simulations with supervised neural models. After that, we exploit our Bayesian models to solve a malware-classification task while being robust to intra-procedural code obfuscation techniques. We conclude the dissertation with an attempt to blend the best of the neural and Bayesian worlds together. The resulting hybrid model is able to predict multimodal distributions conditioned on input graphs, with the consequent ability to model stochasticity and uncertainty better than most works. Overall, we aim to provide a Bayesian perspective into the articulated research field of deep learning for graphs.

Human pose estimation aims to locate the human body parts and build human body representation (e.g., body skeleton) from input data such as images and videos. It has drawn increasing attention during the past decade and has been utilized in a wide range of applications including human-computer interaction, motion analysis, augmented reality, and virtual reality. Although the recently developed deep learning-based solutions have achieved high performance in human pose estimation, there still remain challenges due to insufficient training data, depth ambiguities, and occlusions. The goal of this survey paper is to provide a comprehensive review of recent deep learning-based solutions for both 2D and 3D pose estimation via a systematic analysis and comparison of these solutions based on their input data and inference procedures. More than 240 research papers since 2014 are covered in this survey. Furthermore, 2D and 3D human pose estimation datasets and evaluation metrics are included. Quantitative performance comparisons of the reviewed methods on popular datasets are summarized and discussed. Finally, the challenges involved, applications, and future research directions are concluded. We also provide a regularly updated project page on: \url{//github.com/zczcwh/DL-HPE}

The demand for artificial intelligence has grown significantly over the last decade and this growth has been fueled by advances in machine learning techniques and the ability to leverage hardware acceleration. However, in order to increase the quality of predictions and render machine learning solutions feasible for more complex applications, a substantial amount of training data is required. Although small machine learning models can be trained with modest amounts of data, the input for training larger models such as neural networks grows exponentially with the number of parameters. Since the demand for processing training data has outpaced the increase in computation power of computing machinery, there is a need for distributing the machine learning workload across multiple machines, and turning the centralized into a distributed system. These distributed systems present new challenges, first and foremost the efficient parallelization of the training process and the creation of a coherent model. This article provides an extensive overview of the current state-of-the-art in the field by outlining the challenges and opportunities of distributed machine learning over conventional (centralized) machine learning, discussing the techniques used for distributed machine learning, and providing an overview of the systems that are available.

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