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Carotid artery plaques can cause arterial vascular diseases such as stroke and myocardial infarction, posing a severe threat to human life. However, the current clinical examination mainly relies on a direct assessment by physicians of patients' clinical indicators and medical images, lacking an integrated visualization tool for analyzing the influencing factors and composition of carotid artery plaques. We have designed an intelligent carotid artery plaque visual analysis system for vascular surgery experts to comprehensively analyze the clinical physiological and imaging indicators of carotid artery diseases. The system mainly includes two functions: First, it displays the correlation between carotid artery plaque and various factors through a series of information visualization methods and integrates the analysis of patient physiological indicator data. Second, it enhances the interface guidance analysis of the inherent correlation between the components of carotid artery plaque through machine learning and displays the spatial distribution of the plaque on medical images. Additionally, we conducted two case studies on carotid artery plaques using real data obtained from a hospital, and the results indicate that our designed carotid analysis system can effectively provide clinical diagnosis and treatment guidance for vascular surgeons.

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Integration:Integration, the VLSI Journal。 Explanation:集成,VLSI雜志。 Publisher:Elsevier。 SIT:

In general, robotic dexterous hands are equipped with various sensors for acquiring multimodal contact information such as position, force, and pose of the grasped object. This multi-sensor-based design adds complexity to the robotic system. In contrast, vision-based tactile sensors employ specialized optical designs to enable the extraction of tactile information across different modalities within a single system. Nonetheless, the decoupling design for different modalities in common systems is often independent. Therefore, as the dimensionality of tactile modalities increases, it poses more complex challenges in data processing and decoupling, thereby limiting its application to some extent. Here, we developed a multimodal sensing system based on a vision-based tactile sensor, which utilizes visual representations of tactile information to perceive the multimodal contact information of the grasped object. The visual representations contain extensive content that can be decoupled by a deep neural network to obtain multimodal contact information such as classification, position, posture, and force of the grasped object. The results show that the tactile sensing system can perceive multimodal tactile information using only one single sensor and without different data decoupling designs for different modal tactile information, which reduces the complexity of the tactile system and demonstrates the potential for multimodal tactile integration in various fields such as biomedicine, biology, and robotics.

We investigate the unsupervised constituency parsing task, which organizes words and phrases of a sentence into a hierarchical structure without using linguistically annotated data. We observe that existing unsupervised parsers capture differing aspects of parsing structures, which can be leveraged to enhance unsupervised parsing performance. To this end, we propose a notion of "tree averaging," based on which we further propose a novel ensemble method for unsupervised parsing. To improve inference efficiency, we further distill the ensemble knowledge into a student model; such an ensemble-then-distill process is an effective approach to mitigate the over-smoothing problem existing in common multi-teacher distilling methods. Experiments show that our method surpasses all previous approaches, consistently demonstrating its effectiveness and robustness across various runs, with different ensemble components, and under domain-shift conditions.

The fairness issue of clinical data modeling, especially on Electronic Health Records (EHRs), is of utmost importance due to EHR's complex latent structure and potential selection bias. It is frequently necessary to mitigate health disparity while keeping the model's overall accuracy in practice. However, traditional methods often encounter the trade-off between accuracy and fairness, as they fail to capture the underlying factors beyond observed data. To tackle this challenge, we propose a novel model called Fair Longitudinal Medical Deconfounder (FLMD) that aims to achieve both fairness and accuracy in longitudinal Electronic Health Records (EHR) modeling. Drawing inspiration from the deconfounder theory, FLMD employs a two-stage training process. In the first stage, FLMD captures unobserved confounders for each encounter, which effectively represents underlying medical factors beyond observed EHR, such as patient genotypes and lifestyle habits. This unobserved confounder is crucial for addressing the accuracy/fairness dilemma. In the second stage, FLMD combines the learned latent representation with other relevant features to make predictions. By incorporating appropriate fairness criteria, such as counterfactual fairness, FLMD ensures that it maintains high prediction accuracy while simultaneously minimizing health disparities. We conducted comprehensive experiments on two real-world EHR datasets to demonstrate the effectiveness of FLMD. Apart from the comparison of baseline methods and FLMD variants in terms of fairness and accuracy, we assessed the performance of all models on disturbed/imbalanced and synthetic datasets to showcase the superiority of FLMD across different settings and provide valuable insights into its capabilities.

The interaction of fibers in a viscous (Stokes) fluid plays a crucial role in industrial and biological processes, such as sedimentation, rheology, transport, cell division, and locomotion. Numerical simulations generally rely on slender body theory (SBT), an asymptotic, nonconvergent approximation whose error blows up as fibers approach each other. Yet convergent boundary integral equation (BIE) methods which completely resolve the fiber surface have so far been impractical due to the prohibitive cost of layer-potential quadratures in such high aspect-ratio 3D geometries. We present a high-order Nystr\"om quadrature scheme with aspect-ratio independent cost, making such BIEs practical. It combines centerline panels (each with a small number of poloidal Fourier modes), toroidal Green's functions, generalized Chebyshev quadratures, HPC parallel implementation, and FMM acceleration. We also present new BIE formulations for slender bodies that lead to well conditioned linear systems upon discretization. We test Laplace and Stokes Dirichlet problems, and Stokes mobility problems, for slender rigid closed fibers with (possibly varying) circular cross-section, at separations down to $1/20$ of the slender radius, reporting convergence typically to at least 10 digits. We use this to quantify the breakdown of numerical SBT for close-to-touching rigid fibers. We also apply the methods to time-step the sedimentation of 512 loops with up to $1.65$ million unknowns at around 7 digits of accuracy.

Individualized treatment rules (ITRs) have been widely applied in many fields such as precision medicine and personalized marketing. Beyond the extensive studies on ITR for binary or multiple treatments, there is considerable interest in applying combination treatments. This paper introduces a novel ITR estimation method for combination treatments incorporating interaction effects among treatments. Specifically, we propose the generalized $\psi$-loss as a non-convex surrogate in the residual weighted learning framework, offering desirable statistical and computational properties. Statistically, the minimizer of the proposed surrogate loss is Fisher-consistent with the optimal decision rules, incorporating interaction effects at any intensity level - a significant improvement over existing methods. Computationally, the proposed method applies the difference-of-convex algorithm for efficient computation. Through simulation studies and real-world data applications, we demonstrate the superior performance of the proposed method in recommending combination treatments.

Statically analyzing dynamically-typed code is a challenging endeavor, as even seemingly trivial tasks such as determining the targets of procedure calls are non-trivial without knowing the types of objects at compile time. Addressing this challenge, gradual typing is increasingly added to dynamically-typed languages, a prominent example being TypeScript that introduces static typing to JavaScript. Gradual typing improves the developer's ability to verify program behavior, contributing to robust, secure and debuggable programs. In practice, however, users only sparsely annotate types directly. At the same time, conventional type inference faces performance-related challenges as program size grows. Statistical techniques based on machine learning offer faster inference, but although recent approaches demonstrate overall improved accuracy, they still perform significantly worse on user-defined types than on the most common built-in types. Limiting their real-world usefulness even more, they rarely integrate with user-facing applications. We propose CodeTIDAL5, a Transformer-based model trained to reliably predict type annotations. For effective result retrieval and re-integration, we extract usage slices from a program's code property graph. Comparing our approach against recent neural type inference systems, our model outperforms the current state-of-the-art by 7.85% on the ManyTypes4TypeScript benchmark, achieving 71.27% accuracy overall. Furthermore, we present JoernTI, an integration of our approach into Joern, an open source static analysis tool, and demonstrate that the analysis benefits from the additional type information. As our model allows for fast inference times even on commodity CPUs, making our system available through Joern leads to high accessibility and facilitates security research.

Kinship recognition aims to determine whether the subjects in two facial images are kin or non-kin, which is an emerging and challenging problem. However, most previous methods focus on heuristic designs without considering the spatial correlation between face images. In this paper, we aim to learn discriminative kinship representations embedded with the relation information between face components (e.g., eyes, nose, etc.). To achieve this goal, we propose the Face Componential Relation Network, which learns the relationship between face components among images with a cross-attention mechanism, which automatically learns the important facial regions for kinship recognition. Moreover, we propose Face Componential Relation Network (FaCoRNet), which adapts the loss function by the guidance from cross-attention to learn more discriminative feature representations. The proposed FaCoRNet outperforms previous state-of-the-art methods by large margins for the largest public kinship recognition FIW benchmark.

In the rapidly evolving field of medical imaging, machine learning algorithms have become indispensable for enhancing diagnostic accuracy. However, the effectiveness of these algorithms is contingent upon the availability and organization of high-quality medical imaging datasets. Traditional Digital Imaging and Communications in Medicine (DICOM) data management systems are inadequate for handling the scale and complexity of data required to be facilitated in machine learning algorithms. This paper introduces an innovative data curation tool, developed as part of the Kaapana open-source toolkit, aimed at streamlining the organization, management, and processing of large-scale medical imaging datasets. The tool is specifically tailored to meet the needs of radiologists and machine learning researchers. It incorporates advanced search, auto-annotation and efficient tagging functionalities for improved data curation. Additionally, the tool facilitates quality control and review, enabling researchers to validate image and segmentation quality in large datasets. It also plays a critical role in uncovering potential biases in datasets by aggregating and visualizing metadata, which is essential for developing robust machine learning models. Furthermore, Kaapana is integrated within the Radiological Cooperative Network (RACOON), a pioneering initiative aimed at creating a comprehensive national infrastructure for the aggregation, transmission, and consolidation of radiological data across all university clinics throughout Germany. A supplementary video showcasing the tool's functionalities can be accessed at //bit.ly/MICCAI-DEMI2023.

Rolling bearing fault diagnosis has garnered increased attention in recent years owing to its presence in rotating machinery across various industries, and an ever increasing demand for efficient operations. Prompt detection and accurate prediction of bearing failures can help reduce the likelihood of unexpected machine downtime and enhance maintenance schedules, averting lost productivity. Recent technological advances have enabled monitoring the health of these assets at scale using a variety of sensors, and predicting the failures using modern Machine Learning (ML) approaches including deep learning architectures. Vibration data has been collected using accelerated run-to-failure of overloaded bearings, or by introducing known failure in bearings, under a variety of operating conditions such as rotating speed, load on the bearing, type of bearing fault, and data acquisition frequency. However, in the development of bearing failure classification models using vibration data there is a lack of consensus in the metrics used to evaluate the models, data partitions used to evaluate models, and methods used to generate failure labels in run-to-failure experiments. An understanding of the impact of these choices is important to reliably develop models, and deploy them in practical settings. In this work, we demonstrate the significance of these choices on the performance of the models using publicly-available vibration datasets, and suggest model development considerations for real world scenarios. Our experimental findings demonstrate that assigning vibration data from a given bearing across training and evaluation splits leads to over-optimistic performance estimates, PCA-based approach is able to robustly generate labels for failure classification in run-to-failure experiments, and $F$ scores are more insightful to evaluate the models with unbalanced real-world failure data.

Human doctors with well-structured medical knowledge can diagnose a disease merely via a few conversations with patients about symptoms. In contrast, existing knowledge-grounded dialogue systems often require a large number of dialogue instances to learn as they fail to capture the correlations between different diseases and neglect the diagnostic experience shared among them. To address this issue, we propose a more natural and practical paradigm, i.e., low-resource medical dialogue generation, which can transfer the diagnostic experience from source diseases to target ones with a handful of data for adaptation. It is capitalized on a commonsense knowledge graph to characterize the prior disease-symptom relations. Besides, we develop a Graph-Evolving Meta-Learning (GEML) framework that learns to evolve the commonsense graph for reasoning disease-symptom correlations in a new disease, which effectively alleviates the needs of a large number of dialogues. More importantly, by dynamically evolving disease-symptom graphs, GEML also well addresses the real-world challenges that the disease-symptom correlations of each disease may vary or evolve along with more diagnostic cases. Extensive experiment results on the CMDD dataset and our newly-collected Chunyu dataset testify the superiority of our approach over state-of-the-art approaches. Besides, our GEML can generate an enriched dialogue-sensitive knowledge graph in an online manner, which could benefit other tasks grounded on knowledge graph.

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