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The numerical solution of continuum damage mechanics (CDM) problems suffers from convergence-related challenges during the material softening stage, and consequently existing iterative solvers are subject to a trade-off between computational expense and solution accuracy. In this work, we present a novel unified arc-length (UAL) method, and we derive the formulation of the analytical tangent matrix and governing system of equations for both local and non-local gradient damage problems. Unlike existing versions of arc-length solvers that monolithically scale the external force vector, the proposed method treats the latter as an independent variable and determines the position of the system on the equilibrium path based on all the nodal variations of the external force vector. This approach renders the proposed solver substantially more efficient and robust than existing solvers used in CDM problems. We demonstrate the considerable advantages of the proposed algorithm through several benchmark 1D problems with sharp snap-backs and 2D examples under various boundary conditions and loading scenarios. The proposed UAL approach exhibits a superior ability of overcoming critical increments along the equilibrium path. Moreover, the proposed UAL method is 1-2 orders of magnitude faster than force-controlled arc-length and monolithic Newton-Raphson solvers.

Including information from additional spectral bands (e.g., near-infrared) can improve deep learning model performance for many vision-oriented tasks. There are many possible ways to incorporate this additional information into a deep learning model, but the optimal fusion strategy has not yet been determined and can vary between applications. At one extreme, known as "early fusion," additional bands are stacked as extra channels to obtain an input image with more than three channels. At the other extreme, known as "late fusion," RGB and non-RGB bands are passed through separate branches of a deep learning model and merged immediately before a final classification or segmentation layer. In this work, we characterize the performance of a suite of multispectral deep learning models with different fusion approaches, quantify their relative reliance on different input bands and evaluate their robustness to naturalistic image corruptions affecting one or more input channels.

A rigidity circuit (in 2D) is a minimal dependent set in the rigidity matroid, i.e. a minimal graph supporting a non-trivial stress in any generic placement of its vertices in $\mathbb R^2$. Any rigidity circuit on $n\geq 5$ vertices can be obtained from rigidity circuits on a fewer number of vertices by applying the combinatorial resultant (CR) operation. The inverse operation is called a combinatorial resultant decomposition (CR-decomp). Any rigidity circuit on $n\geq 5$ vertices can be successively decomposed into smaller circuits, until the complete graphs $K_4$ are reached. This sequence of CR-decomps has the structure of a rooted binary tree called the combinatorial resultant tree (CR-tree). A CR-tree encodes an elimination strategy for computing circuit polynomials via Sylvester resultants. Different CR-trees lead to elimination strategies that can vary greatly in time and memory consumption. It is an open problem to establish criteria for optimal CR-trees, or at least to characterize those CR-trees that lead to good elimination strategies. In [12] we presented an algorithm for enumerating CR-trees where we give the algorithms for decomposing 3-connected rigidity circuits in polynomial time. In this paper we focus on those circuits that are not 3-connected, which we simply call 2-connected. In order to enumerate CR-decomps of 2-connected circuits $G$, a brute force exp-time search has to be performed among the subgraphs induced by the subsets of $V(G)$. This exp-time bottleneck is not present in the 3-connected case. In this paper we will argue that we do not have to account for all possible CR-decomps of 2-connected rigidity circuits to find a good elimination strategy; we only have to account for those CR-decomps that are a 2-split, all of which can be enumerated in polynomial time. We present algorithms and computational evidence in support of this heuristic.

With an increasing focus on precision medicine in medical research, numerous studies have been conducted in recent years to clarify the relationship between treatment effects and patient characteristics. The treatment effects for patients with different characteristics are always heterogeneous, and various heterogeneous treatment effect machine learning estimation methods have been proposed owing to their flexibility and high prediction accuracy. However, most machine learning methods rely on black-box models, preventing direct interpretation of the relationship between patient characteristics and treatment effects. Moreover, most of these studies have focused on continuous or binary outcomes, although survival outcomes are also important in medical research. To address these challenges, we propose a heterogeneous treatment effect estimation method for survival data based on RuleFit, an interpretable machine learning method. Numerical simulation results confirmed that the prediction performance of the proposed method was comparable to that of existing methods. We also applied a dataset from an HIV study, the AIDS Clinical Trials Group Protocol 175 dataset, to illustrate the interpretability of the proposed method using real data. Consequently, the proposed method established an interpretable model with sufficient prediction accuracy.

Neuromorphic computing is one of the few current approaches that have the potential to significantly reduce power consumption in Machine Learning and Artificial Intelligence. Imam & Cleland presented an odour-learning algorithm that runs on a neuromorphic architecture and is inspired by circuits described in the mammalian olfactory bulb. They assess the algorithm's performance in "rapid online learning and identification" of gaseous odorants and odorless gases (short "gases") using a set of gas sensor recordings of different odour presentations and corrupting them by impulse noise. We replicated parts of the study and discovered limitations that affect some of the conclusions drawn. First, the dataset used suffers from sensor drift and a non-randomised measurement protocol, rendering it of limited use for odour identification benchmarks. Second, we found that the model is restricted in its ability to generalise over repeated presentations of the same gas. We demonstrate that the task the study refers to can be solved with a simple hash table approach, matching or exceeding the reported results in accuracy and runtime. Therefore, a validation of the model that goes beyond restoring a learned data sample remains to be shown, in particular its suitability to odour identification tasks.

To improve the statistical power for imaging biomarker detection, we propose a latent variable-based statistical network analysis (LatentSNA) that combines brain functional connectivity with internalizing psychopathology, implementing network science in a generative statistical process to preserve the neurologically meaningful network topology in the adolescents and children population. The developed inference-focused generative Bayesian framework (1) addresses the lack of power and inflated Type II errors in current analytic approaches when detecting imaging biomarkers, (2) allows unbiased estimation of biomarkers' influence on behavior variants, (3) quantifies the uncertainty and evaluates the likelihood of the estimated biomarker effects against chance and (4) ultimately improves brain-behavior prediction in novel samples and the clinical utilities of neuroimaging findings. We collectively model multi-state functional networks with multivariate internalizing profiles for 5,000 to 7,000 children in the Adolescent Brain Cognitive Development (ABCD) study with sufficiently accurate prediction of both children internalizing traits and functional connectivity, and substantially improved our ability to explain the individual internalizing differences compared with current approaches. We successfully uncover large, coherent star-like brain functional architectures associated with children's internalizing psychopathology across multiple functional systems and establish them as unique fingerprints for childhood internalization.

We propose an approach to compute inner and outer-approximations of the sets of values satisfying constraints expressed as arbitrarily quantified formulas. Such formulas arise for instance when specifying important problems in control such as robustness, motion planning or controllers comparison. We propose an interval-based method which allows for tractable but tight approximations. We demonstrate its applicability through a series of examples and benchmarks using a prototype implementation.

We hypothesize that due to the greedy nature of learning in multi-modal deep neural networks, these models tend to rely on just one modality while under-fitting the other modalities. Such behavior is counter-intuitive and hurts the models' generalization, as we observe empirically. To estimate the model's dependence on each modality, we compute the gain on the accuracy when the model has access to it in addition to another modality. We refer to this gain as the conditional utilization rate. In the experiments, we consistently observe an imbalance in conditional utilization rates between modalities, across multiple tasks and architectures. Since conditional utilization rate cannot be computed efficiently during training, we introduce a proxy for it based on the pace at which the model learns from each modality, which we refer to as the conditional learning speed. We propose an algorithm to balance the conditional learning speeds between modalities during training and demonstrate that it indeed addresses the issue of greedy learning. The proposed algorithm improves the model's generalization on three datasets: Colored MNIST, Princeton ModelNet40, and NVIDIA Dynamic Hand Gesture.

Graph representation learning for hypergraphs can be used to extract patterns among higher-order interactions that are critically important in many real world problems. Current approaches designed for hypergraphs, however, are unable to handle different types of hypergraphs and are typically not generic for various learning tasks. Indeed, models that can predict variable-sized heterogeneous hyperedges have not been available. Here we develop a new self-attention based graph neural network called Hyper-SAGNN applicable to homogeneous and heterogeneous hypergraphs with variable hyperedge sizes. We perform extensive evaluations on multiple datasets, including four benchmark network datasets and two single-cell Hi-C datasets in genomics. We demonstrate that Hyper-SAGNN significantly outperforms the state-of-the-art methods on traditional tasks while also achieving great performance on a new task called outsider identification. Hyper-SAGNN will be useful for graph representation learning to uncover complex higher-order interactions in different applications.

Recent advances in 3D fully convolutional networks (FCN) have made it feasible to produce dense voxel-wise predictions of volumetric images. In this work, we show that a multi-class 3D FCN trained on manually labeled CT scans of several anatomical structures (ranging from the large organs to thin vessels) can achieve competitive segmentation results, while avoiding the need for handcrafting features or training class-specific models. To this end, we propose a two-stage, coarse-to-fine approach that will first use a 3D FCN to roughly define a candidate region, which will then be used as input to a second 3D FCN. This reduces the number of voxels the second FCN has to classify to ~10% and allows it to focus on more detailed segmentation of the organs and vessels. We utilize training and validation sets consisting of 331 clinical CT images and test our models on a completely unseen data collection acquired at a different hospital that includes 150 CT scans, targeting three anatomical organs (liver, spleen, and pancreas). In challenging organs such as the pancreas, our cascaded approach improves the mean Dice score from 68.5 to 82.2%, achieving the highest reported average score on this dataset. We compare with a 2D FCN method on a separate dataset of 240 CT scans with 18 classes and achieve a significantly higher performance in small organs and vessels. Furthermore, we explore fine-tuning our models to different datasets. Our experiments illustrate the promise and robustness of current 3D FCN based semantic segmentation of medical images, achieving state-of-the-art results. Our code and trained models are available for download: //github.com/holgerroth/3Dunet_abdomen_cascade.