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Mild Traumatic Brain Injury (mTBI) is a significant public health challenge due to its high prevalence and potential for long-term health effects. Despite Computed Tomography (CT) being the standard diagnostic tool for mTBI, it often yields normal results in mTBI patients despite symptomatic evidence. This fact underscores the complexity of accurate diagnosis. In this study, we introduce an interpretable 3D Multi-Modal Residual Convolutional Neural Network (MRCNN) for mTBI diagnostic model enhanced with Occlusion Sensitivity Maps (OSM). Our MRCNN model exhibits promising performance in mTBI diagnosis, demonstrating an average accuracy of 82.4%, sensitivity of 82.6%, and specificity of 81.6%, as validated by a five-fold cross-validation process. Notably, in comparison to the CT-based Residual Convolutional Neural Network (RCNN) model, the MRCNN shows an improvement of 4.4% in specificity and 9.0% in accuracy. We show that the OSM offers superior data-driven insights into CT images compared to the Grad-CAM approach. These results highlight the efficacy of the proposed multi-modal model in enhancing the diagnostic precision of mTBI.

Patients with low health literacy usually have difficulty understanding medical jargon and the complex structure of professional medical language. Although some studies are proposed to automatically translate expert language into layperson-understandable language, only a few of them focus on both accuracy and readability aspects simultaneously in the clinical domain. Thus, simplification of the clinical language is still a challenging task, but unfortunately, it is not yet fully addressed in previous work. To benchmark this task, we construct a new dataset named MedLane to support the development and evaluation of automated clinical language simplification approaches. Besides, we propose a new model called DECLARE that follows the human annotation procedure and achieves state-of-the-art performance compared with eight strong baselines. To fairly evaluate the performance, we also propose three specific evaluation metrics. Experimental results demonstrate the utility of the annotated MedLane dataset and the effectiveness of the proposed model DECLARE.

Generative Artificial Intelligence is set to revolutionize healthcare delivery by transforming traditional patient care into a more personalized, efficient, and proactive process. Chatbots, serving as interactive conversational models, will probably drive this patient-centered transformation in healthcare. Through the provision of various services, including diagnosis, personalized lifestyle recommendations, and mental health support, the objective is to substantially augment patient health outcomes, all the while mitigating the workload burden on healthcare providers. The life-critical nature of healthcare applications necessitates establishing a unified and comprehensive set of evaluation metrics for conversational models. Existing evaluation metrics proposed for various generic large language models (LLMs) demonstrate a lack of comprehension regarding medical and health concepts and their significance in promoting patients' well-being. Moreover, these metrics neglect pivotal user-centered aspects, including trust-building, ethics, personalization, empathy, user comprehension, and emotional support. The purpose of this paper is to explore state-of-the-art LLM-based evaluation metrics that are specifically applicable to the assessment of interactive conversational models in healthcare. Subsequently, we present an comprehensive set of evaluation metrics designed to thoroughly assess the performance of healthcare chatbots from an end-user perspective. These metrics encompass an evaluation of language processing abilities, impact on real-world clinical tasks, and effectiveness in user-interactive conversations. Finally, we engage in a discussion concerning the challenges associated with defining and implementing these metrics, with particular emphasis on confounding factors such as the target audience, evaluation methods, and prompt techniques involved in the evaluation process.

Mobile health studies often collect multiple within-day self-reported assessments of participants' behavior and well-being on different scales such as physical activity (continuous), pain levels (truncated), mood states (ordinal), and life events (binary). These assessments, when indexed by time of day, can be treated as functional data of different types - continuous, truncated, ordinal, and binary. We develop a functional principal component analysis that deals with all four types of functional data in a unified manner. It employs a semiparametric Gaussian copula model, assuming a generalized latent non-paranormal process as the underlying mechanism for these four types of functional data. We specify latent temporal dependence using a covariance estimated through Kendall's tau bridging method, incorporating smoothness during the bridging process. Simulation studies demonstrate the method's competitive performance under both dense and sparse sampling conditions. We then apply this approach to data from 497 participants in the National Institute of Mental Health Family Study of the Mood Disorder Spectrum to characterize within-day temporal patterns of mood differences among individuals with major mood disorder subtypes, including Major Depressive Disorder, Type 1, and Type 2 Bipolar Disorder.

Multimodal medical data fusion has emerged as a transformative approach in smart healthcare, enabling a comprehensive understanding of patient health and personalized treatment plans. In this paper, a journey from data to information to knowledge to wisdom (DIKW) is explored through multimodal fusion for smart healthcare. We present a comprehensive review of multimodal medical data fusion focused on the integration of various data modalities. The review explores different approaches such as feature selection, rule-based systems, machine learning, deep learning, and natural language processing, for fusing and analyzing multimodal data. This paper also highlights the challenges associated with multimodal fusion in healthcare. By synthesizing the reviewed frameworks and theories, it proposes a generic framework for multimodal medical data fusion that aligns with the DIKW model. Moreover, it discusses future directions related to the four pillars of healthcare: Predictive, Preventive, Personalized, and Participatory approaches. The components of the comprehensive survey presented in this paper form the foundation for more successful implementation of multimodal fusion in smart healthcare. Our findings can guide researchers and practitioners in leveraging the power of multimodal fusion with the state-of-the-art approaches to revolutionize healthcare and improve patient outcomes.

Stress is various mental health disorders including depression and anxiety among college students. Early stress diagnosis and intervention may lower the risk of developing mental illnesses. We examined a machine learning-based method for identification of stress using data collected in a naturalistic study utilizing self-reported stress as ground truth as well as physiological data such as heart rate and hand acceleration. The study involved 54 college students from a large campus who used wearable wrist-worn sensors and a mobile health (mHealth) application continuously for 40 days. The app gathered physiological data including heart rate and hand acceleration at one hertz frequency. The application also enabled users to self-report stress by tapping on the watch face, resulting in a time-stamped record of the self-reported stress. We created, evaluated, and analyzed machine learning algorithms for identifying stress episodes among college students using heart rate and accelerometer data. The XGBoost method was the most reliable model with an AUC of 0.64 and an accuracy of 84.5%. The standard deviation of hand acceleration, standard deviation of heart rate, and the minimum heart rate were the most important features for stress detection. This evidence may support the efficacy of identifying patterns in physiological reaction to stress using smartwatch sensors and may inform the design of future tools for real-time detection of stress.

Spiking neuron networks (SNNs) have been thriving on numerous tasks to leverage their promising energy efficiency and exploit their potentialities as biologically plausible intelligence. Meanwhile, the Neural Radiance Fields (NeRF) render high-quality 3D scenes with massive energy consumption, and few works delve into the energy-saving solution with a bio-inspired approach. In this paper, we propose spiking NeRF (SpikingNeRF), which aligns the radiance ray with the temporal dimension of SNN, to naturally accommodate the SNN to the reconstruction of Radiance Fields. Thus, the computation turns into a spike-based, multiplication-free manner, reducing the energy consumption. In SpikingNeRF, each sampled point on the ray is matched onto a particular time step, and represented in a hybrid manner where the voxel grids are maintained as well. Based on the voxel grids, sampled points are determined whether to be masked for better training and inference. However, this operation also incurs irregular temporal length. We propose the temporal condensing-and-padding (TCP) strategy to tackle the masked samples to maintain regular temporal length, i.e., regular tensors, for hardware-friendly computation. Extensive experiments on a variety of datasets demonstrate that our method reduces the $76.74\%$ energy consumption on average and obtains comparable synthesis quality with the ANN baseline.

In contrast to batch learning where all training data is available at once, continual learning represents a family of methods that accumulate knowledge and learn continuously with data available in sequential order. Similar to the human learning process with the ability of learning, fusing, and accumulating new knowledge coming at different time steps, continual learning is considered to have high practical significance. Hence, continual learning has been studied in various artificial intelligence tasks. In this paper, we present a comprehensive review of the recent progress of continual learning in computer vision. In particular, the works are grouped by their representative techniques, including regularization, knowledge distillation, memory, generative replay, parameter isolation, and a combination of the above techniques. For each category of these techniques, both its characteristics and applications in computer vision are presented. At the end of this overview, several subareas, where continuous knowledge accumulation is potentially helpful while continual learning has not been well studied, are discussed.

It has been shown that deep neural networks are prone to overfitting on biased training data. Towards addressing this issue, meta-learning employs a meta model for correcting the training bias. Despite the promising performances, super slow training is currently the bottleneck in the meta learning approaches. In this paper, we introduce a novel Faster Meta Update Strategy (FaMUS) to replace the most expensive step in the meta gradient computation with a faster layer-wise approximation. We empirically find that FaMUS yields not only a reasonably accurate but also a low-variance approximation of the meta gradient. We conduct extensive experiments to verify the proposed method on two tasks. We show our method is able to save two-thirds of the training time while still maintaining the comparable or achieving even better generalization performance. In particular, our method achieves the state-of-the-art performance on both synthetic and realistic noisy labels, and obtains promising performance on long-tailed recognition on standard benchmarks.

Clinical Named Entity Recognition (CNER) aims to identify and classify clinical terms such as diseases, symptoms, treatments, exams, and body parts in electronic health records, which is a fundamental and crucial task for clinical and translational research. In recent years, deep neural networks have achieved significant success in named entity recognition and many other Natural Language Processing (NLP) tasks. Most of these algorithms are trained end to end, and can automatically learn features from large scale labeled datasets. However, these data-driven methods typically lack the capability of processing rare or unseen entities. Previous statistical methods and feature engineering practice have demonstrated that human knowledge can provide valuable information for handling rare and unseen cases. In this paper, we address the problem by incorporating dictionaries into deep neural networks for the Chinese CNER task. Two different architectures that extend the Bi-directional Long Short-Term Memory (Bi-LSTM) neural network and five different feature representation schemes are proposed to handle the task. Computational results on the CCKS-2017 Task 2 benchmark dataset show that the proposed method achieves the highly competitive performance compared with the state-of-the-art deep learning methods.