Alcohol consumption has been shown to influence cardiovascular mechanisms in humans, leading to observable alterations in the plasma metabolomic profile. Regression models are commonly employed to investigate these effects, treating metabolomics features as the outcomes and alcohol intake as the exposure. Given the latent dependence structure among the numerous metabolomic features (e.g., co-expression networks with interconnected modules), modeling this structure is crucial for accurately identifying metabolomic features associated with alcohol intake. However, integrating dependence structures into regression models remains difficult in both estimation and inference procedures due to their large or high dimensionality. To bridge this gap, we propose an innovative multivariate regression model that accounts for correlations among outcome features by incorporating an interconnected community structure. Furthermore, we derive closed-form and likelihood-based estimators, accompanied by explicit exact and explicit asymptotic covariance matrix estimators, respectively. Simulation analysis demonstrates that our approach provides accurate estimation of both dependence and regression coefficients, and enhances sensitivity while maintaining a well-controlled discovery rate, as evidenced through benchmarking against existing regression models. Finally, we apply our approach to assess the impact of alcohol intake on $249$ metabolomic biomarkers measured using nuclear magnetic resonance spectroscopy. The results indicate that alcohol intake can elevate high-density lipoprotein levels by enhancing the transport rate of Apolipoproteins A1.
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ACM/IEEE第23屆模型驅動工程語言和系統國際會議，是模型驅動軟件和系統工程的首要會議系列，由ACM-SIGSOFT和IEEE-TCSE支持組織。自1998年以來，模型涵蓋了建模的各個方面，從語言和方法到工具和應用程序。模特的參加者來自不同的背景，包括研究人員、學者、工程師和工業專業人士。MODELS 2019是一個論壇，參與者可以圍繞建模和模型驅動的軟件和系統交流前沿研究成果和創新實踐經驗。今年的版本將為建模社區提供進一步推進建模基礎的機會，并在網絡物理系統、嵌入式系統、社會技術系統、云計算、大數據、機器學習、安全、開源等新興領域提出建模的創新應用以及可持續性。
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In this work, from a theoretical lens, we aim to understand why large language model (LLM) empowered agents are able to solve decision-making problems in the physical world. To this end, consider a hierarchical reinforcement learning (RL) model where the LLM Planner and the Actor perform high-level task planning and low-level execution, respectively. Under this model, the LLM Planner navigates a partially observable Markov decision process (POMDP) by iteratively generating language-based subgoals via prompting. Under proper assumptions on the pretraining data, we prove that the pretrained LLM Planner effectively performs Bayesian aggregated imitation learning (BAIL) through in-context learning. Additionally, we highlight the necessity for exploration beyond the subgoals derived from BAIL by proving that naively executing the subgoals returned by LLM leads to a linear regret. As a remedy, we introduce an $\epsilon$-greedy exploration strategy to BAIL, which is proven to incur sublinear regret when the pretraining error is small. Finally, we extend our theoretical framework to include scenarios where the LLM Planner serves as a world model for inferring the transition model of the environment and to multi-agent settings, enabling coordination among multiple Actors.
In various biomedical studies, the focus of analysis centers on the magnitudes of data, particularly when algebraic signs are irrelevant or lost. To analyze the magnitude outcomes in repeated measures studies, using models with random effects is essential. This is because random effects can account for individual heterogeneity, enhancing parameter estimation precision. However, there are currently no established regression methods that incorporate random effects and are specifically designed for magnitude outcomes. This article bridges this gap by introducing Bayesian regression modeling approaches for analyzing magnitude data, with a key focus on the incorporation of random effects. Additionally, the proposed method is extended to address multiple causes of informative dropout, commonly encountered in repeated measures studies. To tackle the missing data challenge arising from dropout, a joint modeling strategy is developed, building upon the previously introduced regression techniques. Two numerical simulation studies are conducted to assess the validity of our method. The chosen simulation scenarios aim to resemble the conditions of our motivating study. The results demonstrate that the proposed method for magnitude data exhibits good performance in terms of both estimation accuracy and precision, and the joint models effectively mitigate bias due to missing data. Finally, we apply proposed models to analyze the magnitude data from the motivating study, investigating if sex impacts the magnitude change in diaphragm thickness over time for ICU patients.
Facial expression recognition has gained significance as a means of imparting social robots with the capacity to discern the emotional states of users. The use of social robotics includes a variety of settings, including homes, nursing homes or daycare centers, serving to a wide range of users. Remarkable performance has been achieved by deep learning approaches, however, its direct use for recognizing facial expressions in individuals with intellectual disabilities has not been yet studied in the literature, to the best of our knowledge. To address this objective, we train a set of 12 convolutional neural networks in different approaches, including an ensemble of datasets without individuals with intellectual disabilities and a dataset featuring such individuals. Our examination of the outcomes, both the performance and the important image regions for the models, reveals significant distinctions in facial expressions between individuals with and without intellectual disabilities, as well as among individuals with intellectual disabilities. Remarkably, our findings show the need of facial expression recognition within this population through tailored user-specific training methodologies, which enable the models to effectively address the unique expressions of each user.
With the enhancement in the field of generative artificial intelligence (AI), contextual question answering has become extremely relevant. Attributing model generations to the input source document is essential to ensure trustworthiness and reliability. We observe that when large language models (LLMs) are used for contextual question answering, the output answer often consists of text copied verbatim from the input prompt which is linked together with "glue text" generated by the LLM. Motivated by this, we propose that LLMs have an inherent awareness from where the text was copied, likely captured in the hidden states of the LLM. We introduce a novel method for attribution in contextual question answering, leveraging the hidden state representations of LLMs. Our approach bypasses the need for extensive model retraining and retrieval model overhead, offering granular attributions and preserving the quality of generated answers. Our experimental results demonstrate that our method performs on par or better than GPT-4 at identifying verbatim copied segments in LLM generations and in attributing these segments to their source. Importantly, our method shows robust performance across various LLM architectures, highlighting its broad applicability. Additionally, we present Verifiability-granular, an attribution dataset which has token level annotations for LLM generations in the contextual question answering setup.
Chain-of-thought reasoning, a cognitive process fundamental to human intelligence, has garnered significant attention in the realm of artificial intelligence and natural language processing. However, there still remains a lack of a comprehensive survey for this arena. To this end, we take the first step and present a thorough survey of this research field carefully and widely. We use X-of-Thought to refer to Chain-of-Thought in a broad sense. In detail, we systematically organize the current research according to the taxonomies of methods, including XoT construction, XoT structure variants, and enhanced XoT. Additionally, we describe XoT with frontier applications, covering planning, tool use, and distillation. Furthermore, we address challenges and discuss some future directions, including faithfulness, multi-modal, and theory. We hope this survey serves as a valuable resource for researchers seeking to innovate within the domain of chain-of-thought reasoning.
In pace with developments in the research field of artificial intelligence, knowledge graphs (KGs) have attracted a surge of interest from both academia and industry. As a representation of semantic relations between entities, KGs have proven to be particularly relevant for natural language processing (NLP), experiencing a rapid spread and wide adoption within recent years. Given the increasing amount of research work in this area, several KG-related approaches have been surveyed in the NLP research community. However, a comprehensive study that categorizes established topics and reviews the maturity of individual research streams remains absent to this day. Contributing to closing this gap, we systematically analyzed 507 papers from the literature on KGs in NLP. Our survey encompasses a multifaceted review of tasks, research types, and contributions. As a result, we present a structured overview of the research landscape, provide a taxonomy of tasks, summarize our findings, and highlight directions for future work.
Understanding causality helps to structure interventions to achieve specific goals and enables predictions under interventions. With the growing importance of learning causal relationships, causal discovery tasks have transitioned from using traditional methods to infer potential causal structures from observational data to the field of pattern recognition involved in deep learning. The rapid accumulation of massive data promotes the emergence of causal search methods with brilliant scalability. Existing summaries of causal discovery methods mainly focus on traditional methods based on constraints, scores and FCMs, there is a lack of perfect sorting and elaboration for deep learning-based methods, also lacking some considers and exploration of causal discovery methods from the perspective of variable paradigms. Therefore, we divide the possible causal discovery tasks into three types according to the variable paradigm and give the definitions of the three tasks respectively, define and instantiate the relevant datasets for each task and the final causal model constructed at the same time, then reviews the main existing causal discovery methods for different tasks. Finally, we propose some roadmaps from different perspectives for the current research gaps in the field of causal discovery and point out future research directions.
In contrast to batch learning where all training data is available at once, continual learning represents a family of methods that accumulate knowledge and learn continuously with data available in sequential order. Similar to the human learning process with the ability of learning, fusing, and accumulating new knowledge coming at different time steps, continual learning is considered to have high practical significance. Hence, continual learning has been studied in various artificial intelligence tasks. In this paper, we present a comprehensive review of the recent progress of continual learning in computer vision. In particular, the works are grouped by their representative techniques, including regularization, knowledge distillation, memory, generative replay, parameter isolation, and a combination of the above techniques. For each category of these techniques, both its characteristics and applications in computer vision are presented. At the end of this overview, several subareas, where continuous knowledge accumulation is potentially helpful while continual learning has not been well studied, are discussed.
Deep neural networks have revolutionized many machine learning tasks in power systems, ranging from pattern recognition to signal processing. The data in these tasks is typically represented in Euclidean domains. Nevertheless, there is an increasing number of applications in power systems, where data are collected from non-Euclidean domains and represented as the graph-structured data with high dimensional features and interdependency among nodes. The complexity of graph-structured data has brought significant challenges to the existing deep neural networks defined in Euclidean domains. Recently, many studies on extending deep neural networks for graph-structured data in power systems have emerged. In this paper, a comprehensive overview of graph neural networks (GNNs) in power systems is proposed. Specifically, several classical paradigms of GNNs structures (e.g., graph convolutional networks, graph recurrent neural networks, graph attention networks, graph generative networks, spatial-temporal graph convolutional networks, and hybrid forms of GNNs) are summarized, and key applications in power systems such as fault diagnosis, power prediction, power flow calculation, and data generation are reviewed in detail. Furthermore, main issues and some research trends about the applications of GNNs in power systems are discussed.
Small data challenges have emerged in many learning problems, since the success of deep neural networks often relies on the availability of a huge amount of labeled data that is expensive to collect. To address it, many efforts have been made on training complex models with small data in an unsupervised and semi-supervised fashion. In this paper, we will review the recent progresses on these two major categories of methods. A wide spectrum of small data models will be categorized in a big picture, where we will show how they interplay with each other to motivate explorations of new ideas. We will review the criteria of learning the transformation equivariant, disentangled, self-supervised and semi-supervised representations, which underpin the foundations of recent developments. Many instantiations of unsupervised and semi-supervised generative models have been developed on the basis of these criteria, greatly expanding the territory of existing autoencoders, generative adversarial nets (GANs) and other deep networks by exploring the distribution of unlabeled data for more powerful representations. While we focus on the unsupervised and semi-supervised methods, we will also provide a broader review of other emerging topics, from unsupervised and semi-supervised domain adaptation to the fundamental roles of transformation equivariance and invariance in training a wide spectrum of deep networks. It is impossible for us to write an exclusive encyclopedia to include all related works. Instead, we aim at exploring the main ideas, principles and methods in this area to reveal where we are heading on the journey towards addressing the small data challenges in this big data era.
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