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Ophthalmic diseases represent a significant global health issue, necessitating the use of advanced precise diagnostic tools. Optical Coherence Tomography (OCT) imagery which offers high-resolution cross-sectional images of the retina has become a pivotal imaging modality in ophthalmology. Traditionally physicians have manually detected various diseases and biomarkers from such diagnostic imagery. In recent times, deep learning techniques have been extensively used for medical diagnostic tasks enabling fast and precise diagnosis. This paper presents a novel approach for ophthalmic biomarker detection using an ensemble of Convolutional Neural Network (CNN) and Vision Transformer. While CNNs are good for feature extraction within the local context of the image, transformers are known for their ability to extract features from the global context of the image. Using an ensemble of both techniques allows us to harness the best of both worlds. Our method has been implemented on the OLIVES dataset to detect 6 major biomarkers from the OCT images and shows significant improvement of the macro averaged F1 score on the dataset.

Automated damage detection is an integral component of each structural health monitoring (SHM) system. Typically, measurements from various sensors are collected and reduced to damage-sensitive features, and diagnostic values are generated by statistically evaluating the features. Since changes in data do not only result from damage, it is necessary to determine the confounding factors (environmental or operational variables) and to remove their effects from the measurements or features. Many existing methods for correcting confounding effects are based on different types of mean regression. This neglects potential changes in higher-order statistical moments, but in particular, the output covariances are essential for generating reliable diagnostics for damage detection. This article presents an approach to explicitly quantify the changes in the covariance, using conditional covariance matrices based on a non-parametric, kernel-based estimator. The method is applied to the Munich Test Bridge and the KW51 Railway Bridge in Leuven, covering both raw sensor measurements (acceleration, strain, inclination) and extracted damage-sensitive features (natural frequencies). The results show that covariances between different vibration or inclination sensors can significantly change due to temperature changes, and the same is true for natural frequencies. To highlight the advantages, it is explained how conditional covariances can be combined with standard approaches for damage detection, such as the Mahalanobis distance and principal component analysis. As a result, more reliable diagnostic values can be generated with fewer false alarms.

Artificial Intelligence (AI) and Large Language Models (LLMs) hold significant promise in revolutionizing healthcare, especially in clinical applications. Simultaneously, Digital Twin technology, which models and simulates complex systems, has gained traction in enhancing patient care. However, despite the advances in experimental clinical settings, the potential of AI and digital twins to streamline clinical operations remains largely untapped. This paper introduces a novel digital twin framework specifically designed to enhance oncology clinical operations. We propose the integration of multiple specialized digital twins, such as the Medical Necessity Twin, Care Navigator Twin, and Clinical History Twin, to enhance workflow efficiency and personalize care for each patient based on their unique data. Furthermore, by synthesizing multiple data sources and aligning them with the National Comprehensive Cancer Network (NCCN) guidelines, we create a dynamic Cancer Care Path, a continuously evolving knowledge base that enables these digital twins to provide precise, tailored clinical recommendations.

The application of large language models (LLMs) in healthcare has gained significant attention due to their ability to process complex medical data and provide insights for clinical decision-making. These models have demonstrated substantial capabilities in understanding and generating natural language, which is crucial for medical documentation, diagnostics, and patient interaction. This review examines the trajectory of language models from their early stages to the current state-of-the-art LLMs, highlighting their strengths in healthcare applications and discussing challenges such as data privacy, bias, and ethical considerations. The potential of LLMs to enhance healthcare delivery is explored, alongside the necessary steps to ensure their ethical and effective integration into medical practice.

Generative AI holds immense promise in addressing global healthcare access challenges, with numerous innovative applications now ready for use across various healthcare domains. However, a significant barrier to the widespread adoption of these domain-specific AI solutions is the lack of robust safety mechanisms to effectively manage issues such as hallucination, misinformation, and ensuring truthfulness. Left unchecked, these risks can compromise patient safety and erode trust in healthcare AI systems. While general-purpose frameworks like Llama Guard are useful for filtering toxicity and harmful content, they do not fully address the stringent requirements for truthfulness and safety in healthcare contexts. This paper examines the unique safety and security challenges inherent to healthcare AI, particularly the risk of hallucinations, the spread of misinformation, and the need for factual accuracy in clinical settings. I propose enhancements to existing guardrails frameworks, such as Nvidia NeMo Guardrails, to better suit healthcare-specific needs. By strengthening these safeguards, I aim to ensure the secure, reliable, and accurate use of AI in healthcare, mitigating misinformation risks and improving patient safety.

While large language models (LLMs) have shown promise for medical question answering, there is limited work focused on tropical and infectious disease-specific exploration. We build on an opensource tropical and infectious diseases (TRINDs) dataset, expanding it to include demographic and semantic clinical and consumer augmentations yielding 11000+ prompts. We evaluate LLM performance on these, comparing generalist and medical LLMs, as well as LLM outcomes to human experts. We demonstrate through systematic experimentation, the benefit of contextual information such as demographics, location, gender, risk factors for optimal LLM response. Finally we develop a prototype of TRINDs-LM, a research tool that provides a playground to navigate how context impacts LLM outputs for health.

Large language models (LLMs) have strong capabilities in solving diverse natural language processing tasks. However, the safety and security issues of LLM systems have become the major obstacle to their widespread application. Many studies have extensively investigated risks in LLM systems and developed the corresponding mitigation strategies. Leading-edge enterprises such as OpenAI, Google, Meta, and Anthropic have also made lots of efforts on responsible LLMs. Therefore, there is a growing need to organize the existing studies and establish comprehensive taxonomies for the community. In this paper, we delve into four essential modules of an LLM system, including an input module for receiving prompts, a language model trained on extensive corpora, a toolchain module for development and deployment, and an output module for exporting LLM-generated content. Based on this, we propose a comprehensive taxonomy, which systematically analyzes potential risks associated with each module of an LLM system and discusses the corresponding mitigation strategies. Furthermore, we review prevalent benchmarks, aiming to facilitate the risk assessment of LLM systems. We hope that this paper can help LLM participants embrace a systematic perspective to build their responsible LLM systems.

Understanding causality helps to structure interventions to achieve specific goals and enables predictions under interventions. With the growing importance of learning causal relationships, causal discovery tasks have transitioned from using traditional methods to infer potential causal structures from observational data to the field of pattern recognition involved in deep learning. The rapid accumulation of massive data promotes the emergence of causal search methods with brilliant scalability. Existing summaries of causal discovery methods mainly focus on traditional methods based on constraints, scores and FCMs, there is a lack of perfect sorting and elaboration for deep learning-based methods, also lacking some considers and exploration of causal discovery methods from the perspective of variable paradigms. Therefore, we divide the possible causal discovery tasks into three types according to the variable paradigm and give the definitions of the three tasks respectively, define and instantiate the relevant datasets for each task and the final causal model constructed at the same time, then reviews the main existing causal discovery methods for different tasks. Finally, we propose some roadmaps from different perspectives for the current research gaps in the field of causal discovery and point out future research directions.

Deep neural networks (DNNs) are successful in many computer vision tasks. However, the most accurate DNNs require millions of parameters and operations, making them energy, computation and memory intensive. This impedes the deployment of large DNNs in low-power devices with limited compute resources. Recent research improves DNN models by reducing the memory requirement, energy consumption, and number of operations without significantly decreasing the accuracy. This paper surveys the progress of low-power deep learning and computer vision, specifically in regards to inference, and discusses the methods for compacting and accelerating DNN models. The techniques can be divided into four major categories: (1) parameter quantization and pruning, (2) compressed convolutional filters and matrix factorization, (3) network architecture search, and (4) knowledge distillation. We analyze the accuracy, advantages, disadvantages, and potential solutions to the problems with the techniques in each category. We also discuss new evaluation metrics as a guideline for future research.

Deep convolutional neural networks (CNNs) have recently achieved great success in many visual recognition tasks. However, existing deep neural network models are computationally expensive and memory intensive, hindering their deployment in devices with low memory resources or in applications with strict latency requirements. Therefore, a natural thought is to perform model compression and acceleration in deep networks without significantly decreasing the model performance. During the past few years, tremendous progress has been made in this area. In this paper, we survey the recent advanced techniques for compacting and accelerating CNNs model developed. These techniques are roughly categorized into four schemes: parameter pruning and sharing, low-rank factorization, transferred/compact convolutional filters, and knowledge distillation. Methods of parameter pruning and sharing will be described at the beginning, after that the other techniques will be introduced. For each scheme, we provide insightful analysis regarding the performance, related applications, advantages, and drawbacks etc. Then we will go through a few very recent additional successful methods, for example, dynamic capacity networks and stochastic depths networks. After that, we survey the evaluation matrix, the main datasets used for evaluating the model performance and recent benchmarking efforts. Finally, we conclude this paper, discuss remaining challenges and possible directions on this topic.