Instrumental variables regression is a tool that is commonly used in the analysis of observational data. The instrumental variables are used to make causal inference about the effect of a certain exposure in the presence of unmeasured confounders. A valid instrumental variable is a variable that is associated with the exposure, affects the outcome only through the exposure (exclusion criterion), and is not confounded with the outcome (exogeneity). These assumptions are generally untestable and rely on subject-matter knowledge. Therefore, a sensitivity analysis is desirable to assess the impact of assumptions violation on the estimated parameters. In this paper, we propose and demonstrate a new method of sensitivity analysis for G-estimators in causal linear and non-linear models. We introduce two novel aspects of sensitivity analysis in instrumental variables studies. The first is a single sensitivity parameter that captures violations of exclusion and exogeneity assumptions. The second is an application of the method to non-linear models. The introduced framework is theoretically justified and is illustrated via a simulation study. Finally, we illustrate the method by application to real-world data and provide practitioners with guidelines on conducting sensitivity analysis.
相關內容
Creating large-scale and well-annotated datasets to train AI algorithms is crucial for automated tumor detection and localization. However, with limited resources, it is challenging to determine the best type of annotations when annotating massive amounts of unlabeled data. To address this issue, we focus on polyps in colonoscopy videos and pancreatic tumors in abdominal CT scans; both applications require significant effort and time for pixel-wise annotation due to the high dimensional nature of the data, involving either temporary or spatial dimensions. In this paper, we develop a new annotation strategy, termed Drag&Drop, which simplifies the annotation process to drag and drop. This annotation strategy is more efficient, particularly for temporal and volumetric imaging, than other types of weak annotations, such as per-pixel, bounding boxes, scribbles, ellipses, and points. Furthermore, to exploit our Drag&Drop annotations, we develop a novel weakly supervised learning method based on the watershed algorithm. Experimental results show that our method achieves better detection and localization performance than alternative weak annotations and, more importantly, achieves similar performance to that trained on detailed per-pixel annotations. Interestingly, we find that, with limited resources, allocating weak annotations from a diverse patient population can foster models more robust to unseen images than allocating per-pixel annotations for a small set of images. In summary, this research proposes an efficient annotation strategy for tumor detection and localization that is less accurate than per-pixel annotations but useful for creating large-scale datasets for screening tumors in various medical modalities.
We settle the parameterized complexities of several variants of independent set reconfiguration and dominating set reconfiguration, parameterized by the number of tokens. We show that both problems are XL-complete when there is no limit on the number of moves, XNL-complete when a maximum length $\ell$ for the sequence is given in binary in the input, and XNLP-complete when $\ell$ is given in unary. The problems were known to be $\mathrm{W}[1]$- and $\mathrm{W}[2]$-hard respectively when $\ell$ is also a parameter. We complete the picture by showing membership in those classes. Moreover, we show that for all the variants that we consider, token sliding and token jumping are equivalent under pl-reductions. We introduce partitioned variants of token jumping and token sliding, and give pl-reductions between the four variants that have precise control over the number of tokens and the length of the reconfiguration sequence.
Many statistical problems in causal inference involve a probability distribution other than the one from which data are actually observed; as an additional complication, the object of interest is often a marginal quantity of this other probability distribution. This creates many practical complications for statistical inference, even where the problem is non-parametrically identified. In particular, it is difficult to perform likelihood-based inference, or even to simulate from the model in a general way. We introduce the `frugal parameterization', which places the causal effect of interest at its centre, and then builds the rest of the model around it. We do this in a way that provides a recipe for constructing a regular, non-redundant parameterization using causal quantities of interest. In the case of discrete variables we can use odds ratios to complete the parameterization, while in the continuous case copulas are the natural choice; other possibilities are also discussed. Our methods allow us to construct and simulate from models with parametrically specified causal distributions, and fit them using likelihood-based methods, including fully Bayesian approaches. Our proposal includes parameterizations for the average causal effect and effect of treatment on the treated, as well as other causal quantities of interest.
The advancement of visual intelligence is intrinsically tethered to the availability of large-scale data. In parallel, generative Artificial Intelligence (AI) has unlocked the potential to create synthetic images that closely resemble real-world photographs. This prompts a compelling inquiry: how much visual intelligence could benefit from the advance of generative AI? This paper explores the innovative concept of harnessing these AI-generated images as new data sources, reshaping traditional modeling paradigms in visual intelligence. In contrast to real data, AI-generated data exhibit remarkable advantages, including unmatched abundance and scalability, the rapid generation of vast datasets, and the effortless simulation of edge cases. Built on the success of generative AI models, we examine the potential of their generated data in a range of applications, from training machine learning models to simulating scenarios for computational modeling, testing, and validation. We probe the technological foundations that support this groundbreaking use of generative AI, engaging in an in-depth discussion on the ethical, legal, and practical considerations that accompany this transformative paradigm shift. Through an exhaustive survey of current technologies and applications, this paper presents a comprehensive view of the synthetic era in visual intelligence. A project associated with this paper can be found at //github.com/mwxely/AIGS .
A formulation is developed for deterministically calculating the optimized paths for a multi-agent system consisting of heterogeneous vehicles. The essence of this formulation is the calculation of the shortest time for each agent to reach every grid point from its known initial position. Such arrival time map can be readily assessed using the Fast Marching Method (FMM), a computational algorithm originally designed for solving boundary value problems of the Eikonal equation. Leveraging the FMM method, we demonstrate that the minimal time rendezvous point and paths for all member vehicles can be uniquely determined with minimal computational concerns. To showcase the potential of our method, we use an example of a virtual rendezvous scenario that entails the coordination of a ship, an underwater vehicle, an aerial vehicle, and a ground vehicle to converge at the optimal location within the Tampa Bay area in minimal time. It illustrates the value of the developed framework in efficiently constructing continuous path planning, while accommodating different operational constraints of heterogeneous member vehicles.
Typological information has the potential to be beneficial in the development of NLP models, particularly for low-resource languages. Unfortunately, current large-scale typological databases, notably WALS and Grambank, are inconsistent both with each other and with other sources of typological information, such as linguistic grammars. Some of these inconsistencies stem from coding errors or linguistic variation, but many of the disagreements are due to the discrete categorical nature of these databases. We shed light on this issue by systematically exploring disagreements across typological databases and resources, and their uses in NLP, covering the past and present. We next investigate the future of such work, offering an argument that a continuous view of typological features is clearly beneficial, echoing recommendations from linguistics. We propose that such a view of typology has significant potential in the future, including in language modeling in low-resource scenarios.
We commonly encounter the problem of identifying an optimally weight adjusted version of the empirical distribution of observed data, adhering to predefined constraints on the weights. Such constraints often manifest as restrictions on the moments, tail behaviour, shapes, number of modes, etc., of the resulting weight adjusted empirical distribution. In this article, we substantially enhance the flexibility of such methodology by introducing a nonparametrically imbued distributional constraints on the weights, and developing a general framework leveraging the maximum entropy principle and tools from optimal transport. The key idea is to ensure that the maximum entropy weight adjusted empirical distribution of the observed data is close to a pre-specified probability distribution in terms of the optimal transport metric while allowing for subtle departures. The versatility of the framework is demonstrated in the context of three disparate applications where data re-weighting is warranted to satisfy side constraints on the optimization problem at the heart of the statistical task: namely, portfolio allocation, semi-parametric inference for complex surveys, and ensuring algorithmic fairness in machine learning algorithms.
The semantics used for particular terms in an academic field organically evolve over time. Tracking this evolution through inspection of published literature has either been from the perspective of Linguistic scholars or has concentrated the focus of term evolution within a single domain of study. In this paper, we performed a case study to identify semantic evolution across different domains and identify examples of inter-domain semantic shifts. We initially used keywords as the basis of our search and executed an iterative process of following citations to find the initial mention of the concepts in the field. We found that a select set of keywords like ``semaphore'', ``polymorphism'', and ``ontology'' were mentioned within Computer Science literature and tracked the seminal study that borrowed those terms from original fields by citations. We marked these events as semantic evolution points. Through this manual investigation method, we can identify term evolution across different academic fields. This study reports our initial findings that will seed future automated and computational methods of incorporating concepts from additional academic fields.
Residual networks (ResNets) have displayed impressive results in pattern recognition and, recently, have garnered considerable theoretical interest due to a perceived link with neural ordinary differential equations (neural ODEs). This link relies on the convergence of network weights to a smooth function as the number of layers increases. We investigate the properties of weights trained by stochastic gradient descent and their scaling with network depth through detailed numerical experiments. We observe the existence of scaling regimes markedly different from those assumed in neural ODE literature. Depending on certain features of the network architecture, such as the smoothness of the activation function, one may obtain an alternative ODE limit, a stochastic differential equation or neither of these. These findings cast doubts on the validity of the neural ODE model as an adequate asymptotic description of deep ResNets and point to an alternative class of differential equations as a better description of the deep network limit.
We introduce a multi-task setup of identifying and classifying entities, relations, and coreference clusters in scientific articles. We create SciERC, a dataset that includes annotations for all three tasks and develop a unified framework called Scientific Information Extractor (SciIE) for with shared span representations. The multi-task setup reduces cascading errors between tasks and leverages cross-sentence relations through coreference links. Experiments show that our multi-task model outperforms previous models in scientific information extraction without using any domain-specific features. We further show that the framework supports construction of a scientific knowledge graph, which we use to analyze information in scientific literature.
注冊地址： 北京市海淀區羊坊店路18號2幢3層301-191