Impaired cardiac function has been described as a frequent complication of COVID-19-related pneumonia. To investigate possible underlying mechanisms, we represented the cardiovascular system by means of a lumped-parameter 0D mathematical model. The model was calibrated using clinical data, recorded in 58 patients hospitalized for COVID-19-related pneumonia, to make it patient-specific and to compute model outputs of clinical interest related to the cardiocirculatory system. We assessed, for each patient with a successful calibration, the statistical reliability of model outputs estimating the uncertainty intervals. Then, we performed a statistical analysis to compare healthy ranges and mean values (over patients) of reliable model outputs to determine which were significantly altered in COVID-19-related pneumonia. Our results showed significant increases in right ventricular systolic pressure, diastolic and mean pulmonary arterial pressure, and capillary wedge pressure. Instead, physical quantities related to the systemic circulation were not significantly altered. Remarkably, statistical analyses made on raw clinical data, without the support of a mathematical model, were unable to detect the effects of COVID-19-related pneumonia, thus suggesting that the use of a calibrated 0D mathematical model to describe the cardiocirculatory system is an effective tool to investigate the impairments of the cardiocirculatory system associated with COVID-19.
urvival prediction for cancer patients is critical for optimal treatment selection and patient management. Current patient survival prediction methods typically extract survival information from patients' clinical record data or biological and imaging data. In practice, experienced clinicians can have a preliminary assessment of patients' health status based on patients' observable physical appearances, which are mainly facial features. However, such assessment is highly subjective. In this work, the efficacy of objectively capturing and using prognostic information contained in conventional portrait photographs using deep learning for survival predication purposes is investigated for the first time. A pre-trained StyleGAN2 model is fine-tuned on a custom dataset of our cancer patients' photos to empower its generator with generative ability suitable for patients' photos. The StyleGAN2 is then used to embed the photographs to its highly expressive latent space. Utilizing the state-of-the-art survival analysis models and based on StyleGAN's latent space photo embeddings, this approach achieved a C-index of 0.677, which is notably higher than chance and evidencing the prognostic value embedded in simple 2D facial images. In addition, thanks to StyleGAN's interpretable latent space, our survival prediction model can be validated for relying on essential facial features, eliminating any biases from extraneous information like clothing or background. Moreover, a health attribute is obtained from regression coefficients, which has important potential value for patient care.
We present a revisit of the seeds algorithm to explore the semigroup tree. First, an equivalent definition of seed is presented, which seems easier to manage. Second, we determine the seeds of semigroups with at most three left elements. And third, we find the great-grandchildren of any numerical semigroup in terms of its seeds. The RGD algorithm is the fastest known algorithm at the moment. But if one compares the originary seeds algorithm with the RGD algorithm, one observes that the seeds algorithm uses more elaborated mathematical tools while the RGD algorithm uses data structures that are better adapted to the final C implementations. For genera up to around one half of the maximum size of native integers, the newly defined seeds algorithm performs significantly better than the RGD algorithm. For future compilators allowing larger native sized integers this may constitute a powerful tool to explore the semigroup tree up to genera never explored before. The new seeds algorithm uses bitwise integer operations, the knowledge of the seeds of semigroups with at most three left elements and of the great-grandchildren of any numerical semigroup, apart from techniques such as parallelization and depth first search as wisely introduced in this context by Fromentin and Hivert. The algorithm has been used to prove that there are no Eliahou semigroups of genus $66$, hence proving the Wilf conjecture for genus up to $66$. We also found three Eliahou semigroups of genus $67$. One of these semigroups is neither of Eliahou-Fromentin type, nor of Delgado's type. However, it is a member of a new family suggested by Shalom Eliahou.
Deaf or hard-of-hearing (DHH) speakers typically have atypical speech caused by deafness. With the growing support of speech-based devices and software applications, more work needs to be done to make these devices inclusive to everyone. To do so, we analyze the use of openly-available automatic speech recognition (ASR) tools with a DHH Japanese speaker dataset. As these out-of-the-box ASR models typically do not perform well on DHH speech, we provide a thorough analysis of creating personalized ASR systems. We collected a large DHH speaker dataset of four speakers totaling around 28.05 hours and thoroughly analyzed the performance of different training frameworks by varying the training data sizes. Our findings show that 1000 utterances (or 1-2 hours) from a target speaker can already significantly improve the model performance with minimal amount of work needed, thus we recommend researchers to collect at least 1000 utterances to make an efficient personalized ASR system. In cases where 1000 utterances is difficult to collect, we also discover significant improvements in using previously proposed data augmentation techniques such as intermediate fine-tuning when only 200 utterances are available.
We develop a post-selection inference method for the Cox proportional hazards model with interval-censored data, which provides asymptotically valid p-values and confidence intervals conditional on the model selected by lasso. The method is based on a pivotal quantity that is shown to converge to a uniform distribution under local alternatives. The proof can be adapted to many other regression models, which is illustrated by the extension to generalized linear models and the Cox model with right-censored data. Our method involves estimation of the efficient information matrix, for which several approaches are proposed with proof of their consistency. Thorough simulation studies show that our method has satisfactory performance in samples of modest sizes. The utility of the method is illustrated via an application to an Alzheimer's disease study.
We consider the problem of online allocation subject to a long-term fairness penalty. Contrary to existing works, however, we do not assume that the decision-maker observes the protected attributes -- which is often unrealistic in practice. Instead they can purchase data that help estimate them from sources of different quality; and hence reduce the fairness penalty at some cost. We model this problem as a multi-armed bandit problem where each arm corresponds to the choice of a data source, coupled with the online allocation problem. We propose an algorithm that jointly solves both problems and show that it has a regret bounded by $\mathcal{O}(\sqrt{T})$. A key difficulty is that the rewards received by selecting a source are correlated by the fairness penalty, which leads to a need for randomization (despite a stochastic setting). Our algorithm takes into account contextual information available before the source selection, and can adapt to many different fairness notions. We also show that in some instances, the estimates used can be learned on the fly.
The advent of AI driven large language models (LLMs) have stirred discussions about their role in qualitative research. Some view these as tools to enrich human understanding, while others perceive them as threats to the core values of the discipline. This study aimed to compare and contrast the comprehension capabilities of humans and LLMs. We conducted an experiment with small sample of Alexa app reviews, initially classified by a human analyst. LLMs were then asked to classify these reviews and provide the reasoning behind each classification. We compared the results with human classification and reasoning. The research indicated a significant alignment between human and ChatGPT 3.5 classifications in one third of cases, and a slightly lower alignment with GPT4 in over a quarter of cases. The two AI models showed a higher alignment, observed in more than half of the instances. However, a consensus across all three methods was seen only in about one fifth of the classifications. In the comparison of human and LLMs reasoning, it appears that human analysts lean heavily on their individual experiences. As expected, LLMs, on the other hand, base their reasoning on the specific word choices found in app reviews and the functional components of the app itself. Our results highlight the potential for effective human LLM collaboration, suggesting a synergistic rather than competitive relationship. Researchers must continuously evaluate LLMs role in their work, thereby fostering a future where AI and humans jointly enrich qualitative research.
The estimation of unknown parameters in simulations, also known as calibration, is crucial for practical management of epidemics and prediction of pandemic risk. A simple yet widely used approach is to estimate the parameters by minimizing the sum of the squared distances between actual observations and simulation outputs. It is shown in this paper that this method is inefficient, particularly when the epidemic models are developed based on certain simplifications of reality, also known as imperfect models which are commonly used in practice. To address this issue, a new estimator is introduced that is asymptotically consistent, has a smaller estimation variance than the least squares estimator, and achieves the semiparametric efficiency. Numerical studies are performed to examine the finite sample performance. The proposed method is applied to the analysis of the COVID-19 pandemic for 20 countries based on the SEIR (Susceptible-Exposed-Infectious-Recovered) model with both deterministic and stochastic simulations. The estimation of the parameters, including the basic reproduction number and the average incubation period, reveal the risk of disease outbreaks in each country and provide insights to the design of public health interventions.
Knowledge graph reasoning (KGR) -- answering complex logical queries over large knowledge graphs -- represents an important artificial intelligence task, entailing a range of applications (e.g., cyber threat hunting). However, despite its surging popularity, the potential security risks of KGR are largely unexplored, which is concerning, given the increasing use of such capability in security-critical domains. This work represents a solid initial step towards bridging the striking gap. We systematize the security threats to KGR according to the adversary's objectives, knowledge, and attack vectors. Further, we present ROAR, a new class of attacks that instantiate a variety of such threats. Through empirical evaluation in representative use cases (e.g., medical decision support, cyber threat hunting, and commonsense reasoning), we demonstrate that ROAR is highly effective to mislead KGR to suggest pre-defined answers for target queries, yet with negligible impact on non-target ones. Finally, we explore potential countermeasures against ROAR, including filtering of potentially poisoning knowledge and training with adversarially augmented queries, which leads to several promising research directions.
This paper focuses on the expected difference in borrower's repayment when there is a change in the lender's credit decisions. Classical estimators overlook the confounding effects and hence the estimation error can be magnificent. As such, we propose another approach to construct the estimators such that the error can be greatly reduced. The proposed estimators are shown to be unbiased, consistent, and robust through a combination of theoretical analysis and numerical testing. Moreover, we compare the power of estimating the causal quantities between the classical estimators and the proposed estimators. The comparison is tested across a wide range of models, including linear regression models, tree-based models, and neural network-based models, under different simulated datasets that exhibit different levels of causality, different degrees of nonlinearity, and different distributional properties. Most importantly, we apply our approaches to a large observational dataset provided by a global technology firm that operates in both the e-commerce and the lending business. We find that the relative reduction of estimation error is strikingly substantial if the causal effects are accounted for correctly.
We propose a novel approach to multimodal sentiment analysis using deep neural networks combining visual analysis and natural language processing. Our goal is different than the standard sentiment analysis goal of predicting whether a sentence expresses positive or negative sentiment; instead, we aim to infer the latent emotional state of the user. Thus, we focus on predicting the emotion word tags attached by users to their Tumblr posts, treating these as "self-reported emotions." We demonstrate that our multimodal model combining both text and image features outperforms separate models based solely on either images or text. Our model's results are interpretable, automatically yielding sensible word lists associated with emotions. We explore the structure of emotions implied by our model and compare it to what has been posited in the psychology literature, and validate our model on a set of images that have been used in psychology studies. Finally, our work also provides a useful tool for the growing academic study of images - both photographs and memes - on social networks.