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Clinical trials are vital in advancing drug development and evidence-based medicine, but their success is often hindered by challenges in patient recruitment. In this work, we investigate the potential of large language models (LLMs) to assist individual patients and referral physicians in identifying suitable clinical trials from an extensive selection. Specifically, we introduce TrialGPT, a novel architecture employing LLMs to predict criterion-level eligibility with detailed explanations, which are then aggregated for ranking and excluding candidate clinical trials based on free-text patient notes. We evaluate TrialGPT on three publicly available cohorts of 184 patients and 18,238 annotated clinical trials. The experimental results demonstrate several key findings: First, TrialGPT achieves high criterion-level prediction accuracy with faithful explanations. Second, the aggregated trial-level TrialGPT scores are highly correlated with expert eligibility annotations. Third, these scores prove effective in ranking clinical trials and exclude ineligible candidates. Our error analysis suggests that current LLMs still make some mistakes due to limited medical knowledge and domain-specific context understanding. Nonetheless, we believe the explanatory capabilities of LLMs are highly valuable. Future research is warranted on how such AI assistants can be integrated into the routine trial matching workflow in real-world settings to improve its efficiency.

CT images corrupted by metal artifacts have serious negative effects on clinical diagnosis. Considering the difficulty of collecting paired data with ground truth in clinical settings, unsupervised methods for metal artifact reduction are of high interest. However, it is difficult for previous unsupervised methods to retain structural information from CT images while handling the non-local characteristics of metal artifacts. To address these challenges, we proposed a novel Dense Transformer based Enhanced Coding Network (DTEC-Net) for unsupervised metal artifact reduction. Specifically, we introduce a Hierarchical Disentangling Encoder, supported by the high-order dense process, and transformer to obtain densely encoded sequences with long-range correspondence. Then, we present a second-order disentanglement method to improve the dense sequence's decoding process. Extensive experiments and model discussions illustrate DTEC-Net's effectiveness, which outperforms the previous state-of-the-art methods on a benchmark dataset, and greatly reduces metal artifacts while restoring richer texture details.

Large-scale pre-trained Vision-Language Models (VLMs), such as CLIP, establish the correlation between texts and images, achieving remarkable success on various downstream tasks with fine-tuning. In existing fine-tuning methods, the class-specific text description is matched against the whole image. We recognize that this whole image matching is not effective since images from the same class often contain a set of different semantic objects, and an object further consists of a set of semantic parts or concepts. Individual semantic parts or concepts may appear in image samples from different classes. To address this issue, in this paper, we develop a new method called cross-model concept learning and inference (CCLI). Using the powerful text-image correlation capability of CLIP, our method automatically learns a large set of distinctive visual concepts from images using a set of semantic text concepts. Based on these visual concepts, we construct a discriminative representation of images and learn a concept inference network to perform downstream image classification tasks, such as few-shot learning and domain generalization. Extensive experimental results demonstrate that our CCLI method is able to improve the performance upon the current state-of-the-art methods by large margins, for example, by up to 8.0% improvement on few-shot learning and by up to 1.3% for domain generalization.

Traditional recommender systems leverage users' item preference history to recommend novel content that users may like. However, modern dialog interfaces that allow users to express language-based preferences offer a fundamentally different modality for preference input. Inspired by recent successes of prompting paradigms for large language models (LLMs), we study their use for making recommendations from both item-based and language-based preferences in comparison to state-of-the-art item-based collaborative filtering (CF) methods. To support this investigation, we collect a new dataset consisting of both item-based and language-based preferences elicited from users along with their ratings on a variety of (biased) recommended items and (unbiased) random items. Among numerous experimental results, we find that LLMs provide competitive recommendation performance for pure language-based preferences (no item preferences) in the near cold-start case in comparison to item-based CF methods, despite having no supervised training for this specific task (zero-shot) or only a few labels (few-shot). This is particularly promising as language-based preference representations are more explainable and scrutable than item-based or vector-based representations.

Despite the superior performance, Large Language Models~(LLMs) require significant computational resources for deployment and use. To overcome this issue, quantization methods have been widely applied to reduce the memory footprint of LLMs as well as increasing the inference rate. However, a major challenge is that low-bit quantization methods often lead to performance degradation. It is important to understand how quantization impacts the capacity of LLMs. Different from previous studies focused on overall performance, this work aims to investigate the impact of quantization on \emph{emergent abilities}, which are important characteristics that distinguish LLMs from small language models. Specially, we examine the abilities of in-context learning, chain-of-thought reasoning, and instruction-following in quantized LLMs. Our empirical experiments show that these emergent abilities still exist in 4-bit quantization models, while 2-bit models encounter severe performance degradation on the test of these abilities. To improve the performance of low-bit models, we conduct two special experiments: (1) fine-gained impact analysis that studies which components (or substructures) are more sensitive to quantization, and (2) performance compensation through model fine-tuning. Our work derives a series of important findings to understand the impact of quantization on emergent abilities, and sheds lights on the possibilities of extremely low-bit quantization for LLMs.

Large Language Models (LLMs) have significantly advanced natural language processing (NLP) with their impressive language understanding and generation capabilities. However, their performance may be suboptimal for long-tail or domain-specific tasks due to limited exposure to domain-specific knowledge and vocabulary. Additionally, the lack of transparency of most state-of-the-art (SOTA) LLMs, which can only be accessed via APIs, impedes further fine-tuning with custom data. Moreover, data privacy is a significant concern. To address these challenges, we propose the novel Parametric Knowledge Guiding (PKG) framework, which equips LLMs with a knowledge-guiding module to access relevant knowledge at runtime without altering the LLMs' parameters. Our PKG is based on open-source "white-box" small language models, allowing offline storage of any knowledge that LLMs require. We demonstrate that our PKG framework can enhance the performance of "black-box" LLMs on a range of long-tail and domain-specific downstream tasks requiring factual, tabular, medical, and multimodal knowledge.

Deploying large language models (LLMs) is challenging because they are memory inefficient and compute-intensive for practical applications. In reaction, researchers train smaller task-specific models by either finetuning with human labels or distilling using LLM-generated labels. However, finetuning and distillation require large amounts of training data to achieve comparable performance to LLMs. We introduce Distilling step-by-step, a new mechanism that (a) trains smaller models that outperform LLMs, and (b) achieves so by leveraging less training data needed by finetuning or distillation. Our method extracts LLM rationales as additional supervision for small models within a multi-task training framework. We present three findings across 4 NLP benchmarks: First, compared to both finetuning and distillation, our mechanism achieves better performance with much fewer labeled/unlabeled training examples. Second, compared to LLMs, we achieve better performance using substantially smaller model sizes. Third, we reduce both the model size and the amount of data required to outperform LLMs; our 770M T5 model outperforms the 540B PaLM model using only 80% of available data on a benchmark task.

Recent VQA models may tend to rely on language bias as a shortcut and thus fail to sufficiently learn the multi-modal knowledge from both vision and language. In this paper, we investigate how to capture and mitigate language bias in VQA. Motivated by causal effects, we proposed a novel counterfactual inference framework, which enables us to capture the language bias as the direct causal effect of questions on answers and reduce the language bias by subtracting the direct language effect from the total causal effect. Experiments demonstrate that our proposed counterfactual inference framework 1) is general to various VQA backbones and fusion strategies, 2) achieves competitive performance on the language-bias sensitive VQA-CP dataset while performs robustly on the balanced VQA v2 dataset.

Since hardware resources are limited, the objective of training deep learning models is typically to maximize accuracy subject to the time and memory constraints of training and inference. We study the impact of model size in this setting, focusing on Transformer models for NLP tasks that are limited by compute: self-supervised pretraining and high-resource machine translation. We first show that even though smaller Transformer models execute faster per iteration, wider and deeper models converge in significantly fewer steps. Moreover, this acceleration in convergence typically outpaces the additional computational overhead of using larger models. Therefore, the most compute-efficient training strategy is to counterintuitively train extremely large models but stop after a small number of iterations. This leads to an apparent trade-off between the training efficiency of large Transformer models and the inference efficiency of small Transformer models. However, we show that large models are more robust to compression techniques such as quantization and pruning than small models. Consequently, one can get the best of both worlds: heavily compressed, large models achieve higher accuracy than lightly compressed, small models.