Family history is considered a risk factor for many diseases because it implicitly captures shared genetic, environmental and lifestyle factors. A nationwide electronic health record (EHR) system spanning multiple generations presents new opportunities for studying a connected network of medical histories for entire families. In this work we present a graph-based deep learning approach for learning explainable, supervised representations of how each family member's longitudinal medical history influences a patient's disease risk. We demonstrate that this approach is beneficial for predicting 10-year disease onset for 5 complex disease phenotypes, compared to clinically-inspired and deep learning baselines for a nationwide EHR system comprising 7 million individuals with up to third-degree relatives. Through the use of graph explainability techniques, we illustrate that a graph-based approach enables more personalized modeling of family information and disease risk by identifying important relatives and features for prediction.
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Electrocardiogram (ECG) is a widely used non-invasive diagnostic tool for heart diseases. Many studies have devised ECG analysis models (e.g., classifiers) to assist diagnosis. As an upstream task, researches have built generative models to synthesize ECG data, which are beneficial to providing training samples, privacy protection, and annotation reduction. However, previous generative methods for ECG often neither synthesized multi-view data, nor dealt with heart disease conditions. In this paper, we propose a novel disease-aware generative adversarial network for multi-view ECG synthesis called ME-GAN, which attains panoptic electrocardio representations conditioned on heart diseases and projects the representations onto multiple standard views to yield ECG signals. Since ECG manifestations of heart diseases are often localized in specific waveforms, we propose a new "mixup normalization" to inject disease information precisely into suitable locations. In addition, we propose a view discriminator to revert disordered ECG views into a pre-determined order, supervising the generator to obtain ECG representing correct view characteristics. Besides, a new metric, rFID, is presented to assess the quality of the synthesized ECG signals. Comprehensive experiments verify that our ME-GAN performs well on multi-view ECG signal synthesis with trusty morbid manifestations.
Reasoning, a crucial aspect of NLP research, has not been adequately addressed by prevailing models including Large Language Model. Conversation reasoning, as a critical component of it, remains largely unexplored due to the absence of a well-designed cognitive model. In this paper, inspired by intuition theory on conversation cognition, we develop a conversation cognitive model (CCM) that explains how each utterance receives and activates channels of information recursively. Besides, we algebraically transformed CCM into a structural causal model (SCM) under some mild assumptions, rendering it compatible with various causal discovery methods. We further propose a probabilistic implementation of the SCM for utterance-level relation reasoning. By leveraging variational inference, it explores substitutes for implicit causes, addresses the issue of their unobservability, and reconstructs the causal representations of utterances through the evidence lower bounds. Moreover, we constructed synthetic and simulated datasets incorporating implicit causes and complete cause labels, alleviating the current situation where all available datasets are implicit-causes-agnostic. Extensive experiments demonstrate that our proposed method significantly outperforms existing methods on synthetic, simulated, and real-world datasets. Finally, we analyze the performance of CCM under latent confounders and propose theoretical ideas for addressing this currently unresolved issue.
Platooning technologies enable trucks to drive cooperatively and automatically, which bring benefits including less fuel consumption, more road capacity and safety. In order to establish trust during dynamic platoon formation, ensure vehicular data integrity, and guard platoons against potential attackers, it is pivotal to verify any given vehicle's identity information before granting it access to join a platoon. To address this concern in dynamic truck platooning, we present a novel location-aware and privacy-preserving verification protocol based on zero-knowledge proof and permissioned blockchain. By performing the verification process within the spatially-local area defined by a given platoon, our system can provide lower latency and communication overhead compared to a location-agnostic blockchain system. We prototype the proposed system and perform benchmark tests on the Hyperledger platform. The experimental results show that our system is suitable for real-world truck platooning.
Deep Learning (DL) methods have dramatically increased in popularity in recent years, with significant growth in their application to supervised learning problems in the biomedical sciences. However, the greater prevalence and complexity of missing data in modern biomedical datasets present significant challenges for DL methods. Here, we provide a formal treatment of missing data in the context of deeply learned generalized linear models, a supervised DL architecture for regression and classification problems. We propose a new architecture, \textit{dlglm}, that is one of the first to be able to flexibly account for both ignorable and non-ignorable patterns of missingness in input features and response at training time. We demonstrate through statistical simulation that our method outperforms existing approaches for supervised learning tasks in the presence of missing not at random (MNAR) missingness. We conclude with a case study of a Bank Marketing dataset from the UCI Machine Learning Repository, in which we predict whether clients subscribed to a product based on phone survey data. Supplementary materials for this article are available online.
Display Ads and the generalized assignment problem are two well-studied online packing problems with important applications in ad allocation and other areas. In both problems, ad impressions arrive online and have to be allocated immediately to budget-constrained advertisers. Worst-case algorithms that achieve the ideal competitive ratio are known, but might act overly conservative given the predictable and usually tame nature of real-world input. Given this discrepancy, we develop an algorithm for both problems that incorporate machine-learned predictions and can thus improve the performance beyond the worst-case. Our algorithm is based on the work of Feldman et al. (2009) and similar in nature to Mahdian et al. (2007) who were the first to develop a learning-augmented algorithm for the related, but more structured Ad Words problem. We use a novel analysis to show that our algorithm is able to capitalize on a good prediction, while being robust against poor predictions. We experimentally evaluate our algorithm on synthetic and real-world data on a wide range of predictions. Our algorithm is consistently outperforming the worst-case algorithm without predictions.
In contrast to batch learning where all training data is available at once, continual learning represents a family of methods that accumulate knowledge and learn continuously with data available in sequential order. Similar to the human learning process with the ability of learning, fusing, and accumulating new knowledge coming at different time steps, continual learning is considered to have high practical significance. Hence, continual learning has been studied in various artificial intelligence tasks. In this paper, we present a comprehensive review of the recent progress of continual learning in computer vision. In particular, the works are grouped by their representative techniques, including regularization, knowledge distillation, memory, generative replay, parameter isolation, and a combination of the above techniques. For each category of these techniques, both its characteristics and applications in computer vision are presented. At the end of this overview, several subareas, where continuous knowledge accumulation is potentially helpful while continual learning has not been well studied, are discussed.
Visual recognition is currently one of the most important and active research areas in computer vision, pattern recognition, and even the general field of artificial intelligence. It has great fundamental importance and strong industrial needs. Deep neural networks (DNNs) have largely boosted their performances on many concrete tasks, with the help of large amounts of training data and new powerful computation resources. Though recognition accuracy is usually the first concern for new progresses, efficiency is actually rather important and sometimes critical for both academic research and industrial applications. Moreover, insightful views on the opportunities and challenges of efficiency are also highly required for the entire community. While general surveys on the efficiency issue of DNNs have been done from various perspectives, as far as we are aware, scarcely any of them focused on visual recognition systematically, and thus it is unclear which progresses are applicable to it and what else should be concerned. In this paper, we present the review of the recent advances with our suggestions on the new possible directions towards improving the efficiency of DNN-related visual recognition approaches. We investigate not only from the model but also the data point of view (which is not the case in existing surveys), and focus on three most studied data types (images, videos and points). This paper attempts to provide a systematic summary via a comprehensive survey which can serve as a valuable reference and inspire both researchers and practitioners who work on visual recognition problems.
The military is investigating methods to improve communication and agility in its multi-domain operations (MDO). Nascent popularity of Internet of Things (IoT) has gained traction in public and government domains. Its usage in MDO may revolutionize future battlefields and may enable strategic advantage. While this technology offers leverage to military capabilities, it comes with challenges where one is the uncertainty and associated risk. A key question is how can these uncertainties be addressed. Recently published studies proposed information camouflage to transform information from one data domain to another. As this is comparatively a new approach, we investigate challenges of such transformations and how these associated uncertainties can be detected and addressed, specifically unknown-unknowns to improve decision-making.
We propose a novel approach to multimodal sentiment analysis using deep neural networks combining visual analysis and natural language processing. Our goal is different than the standard sentiment analysis goal of predicting whether a sentence expresses positive or negative sentiment; instead, we aim to infer the latent emotional state of the user. Thus, we focus on predicting the emotion word tags attached by users to their Tumblr posts, treating these as "self-reported emotions." We demonstrate that our multimodal model combining both text and image features outperforms separate models based solely on either images or text. Our model's results are interpretable, automatically yielding sensible word lists associated with emotions. We explore the structure of emotions implied by our model and compare it to what has been posited in the psychology literature, and validate our model on a set of images that have been used in psychology studies. Finally, our work also provides a useful tool for the growing academic study of images - both photographs and memes - on social networks.
Dynamic programming (DP) solves a variety of structured combinatorial problems by iteratively breaking them down into smaller subproblems. In spite of their versatility, DP algorithms are usually non-differentiable, which hampers their use as a layer in neural networks trained by backpropagation. To address this issue, we propose to smooth the max operator in the dynamic programming recursion, using a strongly convex regularizer. This allows to relax both the optimal value and solution of the original combinatorial problem, and turns a broad class of DP algorithms into differentiable operators. Theoretically, we provide a new probabilistic perspective on backpropagating through these DP operators, and relate them to inference in graphical models. We derive two particular instantiations of our framework, a smoothed Viterbi algorithm for sequence prediction and a smoothed DTW algorithm for time-series alignment. We showcase these instantiations on two structured prediction tasks and on structured and sparse attention for neural machine translation.
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