The advancement in healthcare has shifted focus toward patient-centric approaches, particularly in self-care and patient education, facilitated by access to Electronic Health Records (EHR). However, medical jargon in EHRs poses significant challenges in patient comprehension. To address this, we introduce a new task of automatically generating lay definitions, aiming to simplify complex medical terms into patient-friendly lay language. We first created the README dataset, an extensive collection of over 50,000 unique (medical term, lay definition) pairs and 300,000 mentions, each offering context-aware lay definitions manually annotated by domain experts. We have also engineered a data-centric Human-AI pipeline that synergizes data filtering, augmentation, and selection to improve data quality. We then used README as the training data for models and leveraged a Retrieval-Augmented Generation method to reduce hallucinations and improve the quality of model outputs. Our extensive automatic and human evaluations demonstrate that open-source mobile-friendly models, when fine-tuned with high-quality data, are capable of matching or even surpassing the performance of state-of-the-art closed-source large language models like ChatGPT. This research represents a significant stride in closing the knowledge gap in patient education and advancing patient-centric healthcare solutions.
Federated Learning has emerged as a leading approach for decentralized machine learning, enabling multiple clients to collaboratively train a shared model without exchanging private data. While FL enhances data privacy, it remains vulnerable to inference attacks, such as gradient inversion and membership inference, during both training and inference phases. Homomorphic Encryption provides a promising solution by encrypting model updates to protect against such attacks, but it introduces substantial communication overhead, slowing down training and increasing computational costs. To address these challenges, we propose QuanCrypt-FL, a novel algorithm that combines low-bit quantization and pruning techniques to enhance protection against attacks while significantly reducing computational costs during training. Further, we propose and implement mean-based clipping to mitigate quantization overflow or errors. By integrating these methods, QuanCrypt-FL creates a communication-efficient FL framework that ensures privacy protection with minimal impact on model accuracy, thereby improving both computational efficiency and attack resilience. We validate our approach on MNIST, CIFAR-10, and CIFAR-100 datasets, demonstrating superior performance compared to state-of-the-art methods. QuanCrypt-FL consistently outperforms existing method and matches Vanilla-FL in terms of accuracy across varying client. Further, QuanCrypt-FL achieves up to 9x faster encryption, 16x faster decryption, and 1.5x faster inference compared to BatchCrypt, with training time reduced by up to 3x.
Modern medicine demands innovations in medical education, particularly in the learning of human anatomy, traditionally taught through textbooks, dissections, and lectures. Virtual Reality (VR) has emerged as a promising tool to address the limitations of these conventional methods by emphasising vision-based and active learning. However, current VR educational tools are often inaccessible due to high costs and specialised equipment requirements. This paper details the design and development of an accessible, desktop-based VR system aimed at enhancing anatomy education by leveraging the user's visual perception to promote a meaningful and interactive learning experience. The Virtual Anatomy Lab was designed to enable students to interact with a 3D Skull model to complete tasks virtually via an interactive user interface (UI) with the help of common devices like a mouse and keyboard. As part of the study, a group of medical students from prestigious medical schools throughout Malaysia were invited to evaluate the built system to offer feedback and determine its overall efficiency and usability in fulfilling their learning goals. The results and findings from user evaluations were then analysed to discuss its effectiveness and areas for future improvement.
Visual imitation learning methods demonstrate strong performance, yet they lack generalization when faced with visual input perturbations, including variations in lighting and textures, impeding their real-world application. We propose Stem-OB that utilizes pretrained image diffusion models to suppress low-level visual differences while maintaining high-level scene structures. This image inversion process is akin to transforming the observation into a shared representation, from which other observations stem, with extraneous details removed. Stem-OB contrasts with data-augmentation approaches as it is robust to various unspecified appearance changes without the need for additional training. Our method is a simple yet highly effective plug-and-play solution. Empirical results confirm the effectiveness of our approach in simulated tasks and show an exceptionally significant improvement in real-world applications, with an average increase of 22.2% in success rates compared to the best baseline. See //hukz18.github.io/Stem-Ob/ for more info.
The healthcare landscape is evolving, with patients seeking reliable information about their health conditions and available treatment options. Despite the abundance of information sources, the digital age overwhelms individuals with excess, often inaccurate information. Patients primarily trust medical professionals, highlighting the need for expert-endorsed health information. However, increased patient loads on experts has led to reduced communication time, impacting information sharing. To address this gap, we developed CataractBot, an experts-in-the-loop chatbot powered by LLMs, in collaboration with an eye hospital in India. CataractBot answers cataract surgery related questions instantly by querying a curated knowledge base and provides expert-verified responses asynchronously. It has multimodal and multilingual capabilities. In an in-the-wild deployment study with 55 participants, CataractBot proved valuable, providing anytime accessibility, saving time, accommodating diverse literacy levels, alleviating power differences, and adding a privacy layer between patients and doctors. Users reported that their trust in the system was established through expert verification. Broadly, our results could inform future work on designing expert-mediated LLM bots.
To increase social bonding with interlocutors, humans naturally acquire the ability to respond appropriately in a given situation by considering which conversational skill is most suitable for the response - a process we call skill-of-mind. For large language model (LLM)-based conversational agents, planning appropriate conversational skills, as humans do, is challenging due to the complexity of social dialogue, especially in interactive scenarios. To address this, we propose a skill-of-mind-annotated conversation dataset, named Multifaceted Skill-of-Mind, which includes multi-turn and multifaceted conversational skills across various interactive scenarios (e.g., long-term, counseling, task-oriented), grounded in diverse social contexts (e.g., demographics, persona, rules of thumb). This dataset consists of roughly 100K conversations. Using this dataset, we introduce a new family of skill-of-mind-infused LLMs, named Thanos, with model sizes of 1B, 3B, and 8B parameters. With extensive experiments, these models successfully demonstrate the skill-of-mind process and exhibit strong generalizability in inferring multifaceted skills across a variety of domains. Moreover, we show that Thanos significantly enhances the quality of responses generated by LLM-based conversational agents and promotes prosocial behavior in human evaluations.
Binary malware summarization aims to automatically generate human-readable descriptions of malware behaviors from executable files, facilitating tasks like malware cracking and detection. Previous methods based on Large Language Models (LLMs) have shown great promise. However, they still face significant issues, including poor usability, inaccurate explanations,and incomplete summaries, primarily due to the obscure pseudocode structure and the lack of malware training summaries. Further, calling relationships between functions, which involve the rich interactions within a binary malware, remain largely underexplored. To this end, we propose MALSIGHT, a novel code summarization framework that can iteratively generate descriptions of binary malware by exploring malicious source code and benign pseudocode. Specifically, we construct the first malware summary dataset, MalS and MalP, using an LLM and manually refine this dataset with human effort. At the training stage, we tune our proposed MalT5, a novel LLM-based code model, on the MalS and benign pseudocode datasets. Then, at the test stage, we iteratively feed the pseudocode functions into MalT5 to obtain the summary. Such a procedure facilitates the understanding of pseudocode structure and captures the intricate interactions between functions, thereby benefiting summaries' usability, accuracy, and completeness. Additionally, we propose a novel evaluation benchmark, BLEURT-sum, to measure the quality of summaries. Experiments on three datasets show the effectiveness of the proposed MALSIGHT. Notably, our proposed MalT5, with only 0.77B parameters, delivers comparable performance to much larger Code-Llama.
Watermarking generative content serves as a vital tool for authentication, ownership protection, and mitigation of potential misuse. Existing watermarking methods face the challenge of balancing robustness and concealment. They empirically inject a watermark that is both invisible and robust and passively achieve concealment by limiting the strength of the watermark, thus reducing the robustness. In this paper, we propose to explicitly introduce a watermark hiding process to actively achieve concealment, thus allowing the embedding of stronger watermarks. To be specific, we implant a robust watermark in an intermediate diffusion state and then guide the model to hide the watermark in the final generated image. We employ an adversarial optimization algorithm to produce the optimal hiding prompt guiding signal for each watermark. The prompt embedding is optimized to minimize artifacts in the generated image, while the watermark is optimized to achieve maximum strength. The watermark can be verified by reversing the generation process. Experiments on various diffusion models demonstrate the watermark remains verifiable even under significant image tampering and shows superior invisibility compared to other state-of-the-art robust watermarking methods.
Diffusion model-based approaches recently achieved re-markable success in MRI reconstruction, but integration into clinical routine remains challenging due to its time-consuming convergence. This phenomenon is partic-ularly notable when directly apply conventional diffusion process to k-space data without considering the inherent properties of k-space sampling, limiting k-space learning efficiency and image reconstruction quality. To tackle these challenges, we introduce subspace diffusion model with orthogonal decomposition, a method (referred to as Sub-DM) that restrict the diffusion process via projections onto subspace as the k-space data distribution evolves toward noise. Particularly, the subspace diffusion model circumvents the inference challenges posed by the com-plex and high-dimensional characteristics of k-space data, so the highly compact subspace ensures that diffusion process requires only a few simple iterations to produce accurate prior information. Furthermore, the orthogonal decomposition strategy based on wavelet transform hin-ders the information loss during the migration of the vanilla diffusion process to the subspace. Considering the strate-gy is approximately reversible, such that the entire pro-cess can be reversed. As a result, it allows the diffusion processes in different spaces to refine models through a mutual feedback mechanism, enabling the learning of ac-curate prior even when dealing with complex k-space data. Comprehensive experiments on different datasets clearly demonstrate that the superiority of Sub-DM against state of-the-art methods in terms of reconstruction speed and quality.
3D semantic occupancy prediction is crucial for finely representing the surrounding environment, which is essential for ensuring the safety in autonomous driving. Existing fusion-based occupancy methods typically involve performing a 2D-to-3D view transformation on image features, followed by computationally intensive 3D operations to fuse these with LiDAR features, leading to high computational costs and reduced accuracy. Moreover, current research on occupancy prediction predominantly focuses on designing specific network architectures, often tailored to particular models, with limited attention given to the more fundamental aspect of semantic feature learning. This gap hinders the development of more transferable methods that could enhance the performance of various occupancy models. To address these challenges, we propose OccLoff, a framework that Learns to Optimize Feature Fusion for 3D occupancy prediction. Specifically, we introduce a sparse fusion encoder with entropy masks that directly fuses 3D and 2D features, improving model accuracy while reducing computational overhead. Additionally, we propose a transferable proxy-based loss function and an adaptive hard sample weighting algorithm, which enhance the performance of several state-of-the-art methods. Extensive evaluations on the nuScenes and SemanticKITTI benchmarks demonstrate the superiority of our framework, and ablation studies confirm the effectiveness of each proposed module.
Identifying the relationship between healthcare attributes, lifestyles, and personality is vital for understanding and improving physical and mental well-being. Machine learning approaches are promising for modeling their relationships and offering actionable suggestions. In this paper, we propose Virtual Human Generative Model (VHGM), a machine learning model for estimating healthcare, lifestyles, and personality attributes. VHGM is a deep generative model trained with masked modeling to learn the joint distribution of attributes conditioned on known ones. Using heterogeneous tabular datasets, VHGM learns more than 2,000 attributes efficiently. We numerically evaluate the performance of VHGM and its training techniques and have deployed VHGM as a Web service, enabling various healthcare applications.