Anterior segment optical coherence tomography (AS-OCT) is a non-invasive imaging technique that is highly valuable for ophthalmic diagnosis. However, speckles in AS-OCT images can often degrade the image quality and affect clinical analysis. As a result, removing speckles in AS-OCT images can greatly benefit automatic ophthalmology analysis. Unfortunately, challenges still exist in deploying effective AS-OCT image denoising algorithms, including collecting sufficient paired training data and the requirement to preserve consistent content in medical images. To address these practical issues, we propose an unsupervised AS-OCT despeckling algorithm via Content Preserving Diffusion Model (CPDM) with statistical knowledge. At the training stage, a Markov chain transforms clean images to white Gaussian noise by repeatedly adding random noise and removes the predicted noise in a reverse procedure. At the inference stage, we first analyze the statistical distribution of speckles and convert it into a Gaussian distribution, aiming to match the fast truncated reverse diffusion process. We then explore the posterior distribution of observed images as a fidelity term to ensure content consistency in the iterative procedure. Our experimental results show that CPDM significantly improves image quality compared to competitive methods. Furthermore, we validate the benefits of CPDM for subsequent clinical analysis, including ciliary muscle (CM) segmentation and scleral spur (SS) localization.
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We present the Dirichlet-Neumann (DN) and Neumann-Neumann (NN) methods applied to the optimal control problems arising from elliptic partial differential equations (PDEs) under the $H^{-1}$ regularization. We use the Lagrange multiplier approach to derive a forward-backward optimality system with the $L^2$ regularization, and a singular perturbed Poisson equation with the $H^{-1}$ regularization. The $H^{-1}$ regularization thus avoids solving a coupled bi-Laplacian problem, yet the solutions are less regular. The singular perturbed Poisson equation is then solved by using the DN and NN methods, and a detailed analysis is given both in the one-dimensional and two-dimensional case. Finally, we provide some numerical experiments with conclusions.
Resting-state functional MRI (rs-fMRI) is increasingly employed in multi-site research to aid neurological disorder analysis. Existing studies usually suffer from significant cross-site/domain data heterogeneity caused by site effects such as differences in scanners/protocols. Many methods have been proposed to reduce fMRI heterogeneity between source and target domains, heavily relying on the availability of source data. But acquiring source data is challenging due to privacy concerns and/or data storage burdens in multi-site studies. To this end, we design a source-free collaborative domain adaptation (SCDA) framework for fMRI analysis, where only a pretrained source model and unlabeled target data are accessible. Specifically, a multi-perspective feature enrichment method (MFE) is developed for target fMRI analysis, consisting of multiple collaborative branches to dynamically capture fMRI features of unlabeled target data from multiple views. Each branch has a data-feeding module, a spatiotemporal feature encoder, and a class predictor. A mutual-consistency constraint is designed to encourage pair-wise consistency of latent features of the same input generated from these branches for robust representation learning. To facilitate efficient cross-domain knowledge transfer without source data, we initialize MFE using parameters of a pretrained source model. We also introduce an unsupervised pretraining strategy using 3,806 unlabeled fMRIs from three large-scale auxiliary databases, aiming to obtain a general feature encoder. Experimental results on three public datasets and one private dataset demonstrate the efficacy of our method in cross-scanner and cross-study prediction tasks. The model pretrained on large-scale rs-fMRI data has been released to the public.
The magnetic inversion method is one of the non-destructive geophysical methods, which aims to estimate the subsurface susceptibility distribution from surface magnetic anomaly data. Recently, supervised deep learning methods have been widely utilized in lots of geophysical fields including magnetic inversion. However, these methods rely heavily on synthetic training data, whose performance is limited since the synthetic data is not independently and identically distributed with the field data. Thus, we proposed to realize magnetic inversion by self-supervised deep learning. The proposed self-supervised knowledge-driven 3D magnetic inversion method (SSKMI) learns on the target field data by a closed loop of the inversion and forward models. Given that the parameters of the forward model are preset, SSKMI can optimize the inversion model by minimizing the mean absolute error between observed and re-estimated surface magnetic anomalies. Besides, there is a knowledge-driven module in the proposed inversion model, which makes the deep learning method more explicable. Meanwhile, comparative experiments demonstrate that the knowledge-driven module can accelerate the training of the proposed method and achieve better results. Since magnetic inversion is an ill-pose task, SSKMI proposed to constrain the inversion model by a guideline in the auxiliary loop. The experimental results demonstrate that the proposed method is a reliable magnetic inversion method with outstanding performance.
Instance segmentation in electron microscopy (EM) volumes poses a significant challenge due to the complex morphology of instances and insufficient annotations. Self-supervised learning has recently emerged as a promising solution, enabling the acquisition of prior knowledge of cellular tissue structures that are essential for EM instance segmentation. However, existing pretraining methods often lack the ability to capture complex visual patterns and relationships between voxels, which results in the acquired prior knowledge being insufficient for downstream EM analysis tasks. In this paper, we propose a novel pretraining framework that leverages multiscale visual representations to capture both voxel-level and feature-level consistency in EM volumes. Specifically, our framework enforces voxel-level consistency between the outputs of a Siamese network by a reconstruction function, and incorporates a cross-attention mechanism for soft feature matching to achieve fine-grained feature-level consistency. Moreover, we propose a contrastive learning scheme on the feature pyramid to extract discriminative features across multiple scales. We extensively pretrain our method on four large-scale EM datasets, achieving promising performance improvements in representative tasks of neuron and mitochondria instance segmentation.
Face rendering using neural radiance fields (NeRF) is a rapidly developing research area in computer vision. While recent methods primarily focus on controlling facial attributes such as identity and expression, they often overlook the crucial aspect of modeling eyeball rotation, which holds importance for various downstream tasks. In this paper, we aim to learn a face NeRF model that is sensitive to eye movements from multi-view images. We address two key challenges in eye-aware face NeRF learning: how to effectively capture eyeball rotation for training and how to construct a manifold for representing eyeball rotation. To accomplish this, we first fit FLAME, a well-established parametric face model, to the multi-view images considering multi-view consistency. Subsequently, we introduce a new Dynamic Eye-aware NeRF (DeNeRF). DeNeRF transforms 3D points from different views into a canonical space to learn a unified face NeRF model. We design an eye deformation field for the transformation, including rigid transformation, e.g., eyeball rotation, and non-rigid transformation. Through experiments conducted on the ETH-XGaze dataset, we demonstrate that our model is capable of generating high-fidelity images with accurate eyeball rotation and non-rigid periocular deformation, even under novel viewing angles. Furthermore, we show that utilizing the rendered images can effectively enhance gaze estimation performance.
Deep neural networks (NNs) are considered a powerful tool for balancing the performance and complexity of multiple-input multiple-output (MIMO) receivers due to their accurate feature extraction, high parallelism, and excellent inference ability. Graph NNs (GNNs) have recently demonstrated outstanding capability in learning enhanced message passing rules and have shown success in overcoming the drawback of inaccurate Gaussian approximation of expectation propagation (EP)-based MIMO detectors. However, the application of the GNN-enhanced EP detector to MIMO turbo receivers is underexplored and non-trivial due to the requirement of extrinsic information for iterative processing. This paper proposes a GNN-enhanced EP algorithm for MIMO turbo receivers, which realizes the turbo principle of generating extrinsic information from the MIMO detector through a specially designed training procedure. Additionally, an edge pruning strategy is designed to eliminate redundant connections in the original fully connected model of the GNN utilizing the correlation information inherently from the EP algorithm. Edge pruning reduces the computational cost dramatically and enables the network to focus more attention on the weights that are vital for performance. Simulation results and complexity analysis indicate that the proposed MIMO turbo receiver outperforms the EP turbo approaches by over 1 dB at the bit error rate of $10^{-5}$, exhibits performance equivalent to state-of-the-art receivers with 2.5 times shorter running time, and adapts to various scenarios.
T1 mapping is a quantitative magnetic resonance imaging (qMRI) technique that has emerged as a valuable tool in the diagnosis of diffuse myocardial diseases. However, prevailing approaches have relied heavily on breath-hold sequences to eliminate respiratory motion artifacts. This limitation hinders accessibility and effectiveness for patients who cannot tolerate breath-holding. Image registration can be used to enable free-breathing T1 mapping. Yet, inherent intensity differences between the different time points make the registration task challenging. We introduce PCMC-T1, a physically-constrained deep-learning model for motion correction in free-breathing T1 mapping. We incorporate the signal decay model into the network architecture to encourage physically-plausible deformations along the longitudinal relaxation axis. We compared PCMC-T1 to baseline deep-learning-based image registration approaches using a 5-fold experimental setup on a publicly available dataset of 210 patients. PCMC-T1 demonstrated superior model fitting quality (R2: 0.955) and achieved the highest clinical impact (clinical score: 3.93) compared to baseline methods (0.941, 0.946 and 3.34, 3.62 respectively). Anatomical alignment results were comparable (Dice score: 0.9835 vs. 0.984, 0.988). Our code and trained models are available at //github.com/eyalhana/PCMC-T1.
As the feature size of integrated circuits continues to decrease, optical proximity correction (OPC) has emerged as a crucial resolution enhancement technology for ensuring high printability in the lithography process. Recently, level set-based inverse lithography technology (ILT) has drawn considerable attention as a promising OPC solution, showcasing its powerful pattern fidelity, especially in advanced process. However, massive computational time consumption of ILT limits its applicability to mainly correcting partial layers and hotspot regions. Deep learning (DL) methods have shown great potential in accelerating ILT. However, lack of domain knowledge of inverse lithography limits the ability of DL-based algorithms in process window (PW) enhancement and etc. In this paper, we propose an inverse lithography physics-informed deep neural level set (ILDLS) approach for mask optimization. This approach utilizes level set based-ILT as a layer within the DL framework and iteratively conducts mask prediction and correction to significantly enhance printability and PW in comparison with results from pure DL and ILT. With this approach, computation time is reduced by a few orders of magnitude versus ILT. By gearing up DL with knowledge of inverse lithography physics, ILDLS provides a new and efficient mask optimization solution.
Image-level weakly supervised semantic segmentation (WSSS) is a fundamental yet challenging computer vision task facilitating scene understanding and automatic driving. Most existing methods resort to classification-based Class Activation Maps (CAMs) to play as the initial pseudo labels, which tend to focus on the discriminative image regions and lack customized characteristics for the segmentation task. To alleviate this issue, we propose a novel activation modulation and recalibration (AMR) scheme, which leverages a spotlight branch and a compensation branch to obtain weighted CAMs that can provide recalibration supervision and task-specific concepts. Specifically, an attention modulation module (AMM) is employed to rearrange the distribution of feature importance from the channel-spatial sequential perspective, which helps to explicitly model channel-wise interdependencies and spatial encodings to adaptively modulate segmentation-oriented activation responses. Furthermore, we introduce a cross pseudo supervision for dual branches, which can be regarded as a semantic similar regularization to mutually refine two branches. Extensive experiments show that AMR establishes a new state-of-the-art performance on the PASCAL VOC 2012 dataset, surpassing not only current methods trained with the image-level of supervision but also some methods relying on stronger supervision, such as saliency label. Experiments also reveal that our scheme is plug-and-play and can be incorporated with other approaches to boost their performance.
Video captioning is a challenging task that requires a deep understanding of visual scenes. State-of-the-art methods generate captions using either scene-level or object-level information but without explicitly modeling object interactions. Thus, they often fail to make visually grounded predictions, and are sensitive to spurious correlations. In this paper, we propose a novel spatio-temporal graph model for video captioning that exploits object interactions in space and time. Our model builds interpretable links and is able to provide explicit visual grounding. To avoid unstable performance caused by the variable number of objects, we further propose an object-aware knowledge distillation mechanism, in which local object information is used to regularize global scene features. We demonstrate the efficacy of our approach through extensive experiments on two benchmarks, showing our approach yields competitive performance with interpretable predictions.
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