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In this paper, we investigate the ergodic sum rate (ESR) capacity achieving uplink (UL) transmit design for massive multiple-input multiple-output (MIMO) low-earth-orbit (LEO) satellite communications with statistical channel state information at the user terminals (UTs). The UL massive MIMO LEO satellite channel model with uniform planar array configurations at the satellite and UTs is presented. We prove that the rank of each UT's optimal transmit covariance matrix does not exceed that of its channel correlation matrix at the UT side, which reveals the maximum number of independent data streams transmitted from each UT to the satellite. We then prove that the transmit covariance matrix design can be transformed into the lower-dimensional matrix design without loss of optimality. We also obtain a necessary and sufficient condition when single data stream transmission from each UT to the satellite can achieve the ESR capacity. A conditional gradient (CG) method is developed to compute the ESR capacity achieving transmit covariance matrices. Furthermore, to avoid the exhaustive sample average, we utilize an asymptotic expression of the ESR and devise a simplified CG method to compute the transmit covariance matrices, which can approximate the ESR capacity. Simulations demonstrate the effectiveness of the proposed approaches.

Among different phases of the life cycle of a building or facility, design is of the utmost importance to ensure safety, efficiency and sustainability of the building or facility. How to control and improve design quality and efficiency has been explored for years, and more studies emerged with the popularization of Building Information Modelling (BIM). However, most of them focused on the extraction of design behaviors, while paying less attention to how a design is formed. Therefore, this study proposes an approach to tracking and replaying the BIM-based design process by integrating data logging and 4D visualization techniques. First of all, potential design behaviors and procedures are analyzed and extracted by observing how a designer designs a BIM model. Meanwhile, the required data for logging design process is defined and a relevant method to collect these data is developed based on the APIs of BIM software. Then, strategies on how to visualize different design procedures are designed and implemented via 4D visualization. Finally, a prototype system is developed based on Autodesk Revit and validated through a case study. Result shows that the proposed approach enables intuitively and interactively review of the design process, and makes it easier to understand design behaviors and even identify potential pitfalls, thus improving the design efficiency and quality.

Just-in-Time Adaptive Interventions (JITAIs) are a class of personalized health interventions developed within the behavioral science community. JITAIs aim to provide the right type and amount of support by iteratively selecting a sequence of intervention options from a pre-defined set of components in response to each individual's time varying state. In this work, we explore the application of reinforcement learning methods to the problem of learning intervention option selection policies. We study the effect of context inference error and partial observability on the ability to learn effective policies. Our results show that the propagation of uncertainty from context inferences is critical to improving intervention efficacy as context uncertainty increases, while policy gradient algorithms can provide remarkable robustness to partially observed behavioral state information.

Estimating the pose of an uncooperative spacecraft is an important computer vision problem for enabling the deployment of automatic vision-based systems in orbit, with applications ranging from on-orbit servicing to space debris removal. Following the general trend in computer vision, more and more works have been focusing on leveraging Deep Learning (DL) methods to address this problem. However and despite promising research-stage results, major challenges preventing the use of such methods in real-life missions still stand in the way. In particular, the deployment of such computation-intensive algorithms is still under-investigated, while the performance drop when training on synthetic and testing on real images remains to mitigate. The primary goal of this survey is to describe the current DL-based methods for spacecraft pose estimation in a comprehensive manner. The secondary goal is to help define the limitations towards the effective deployment of DL-based spacecraft pose estimation solutions for reliable autonomous vision-based applications. To this end, the survey first summarises the existing algorithms according to two approaches: hybrid modular pipelines and direct end-to-end regression methods. A comparison of algorithms is presented not only in terms of pose accuracy but also with a focus on network architectures and models' sizes keeping potential deployment in mind. Then, current monocular spacecraft pose estimation datasets used to train and test these methods are discussed. The data generation methods: simulators and testbeds, the domain gap and the performance drop between synthetically generated and lab/space collected images and the potential solutions are also discussed. Finally, the paper presents open research questions and future directions in the field, drawing parallels with other computer vision applications.

External validation is often recommended to ensure the generalizability of ML models. However, it neither guarantees generalizability nor equates to a model's clinical usefulness (the ultimate goal of any clinical decision-support tool). External validation is misaligned with current healthcare ML needs. First, patient data changes across time, geography, and facilities. These changes create significant volatility in the performance of a single fixed model (especially for deep learning models, which dominate clinical ML). Second, newer ML techniques, current market forces, and updated regulatory frameworks are enabling frequent updating and monitoring of individual deployed model instances. We submit that external validation is insufficient to establish ML models' safety or utility. Proposals to fix the external validation paradigm do not go far enough. Continued reliance on it as the ultimate test is likely to lead us astray. We propose the MLOps-inspired paradigm of recurring local validation as an alternative that ensures the validity of models while protecting against performance-disruptive data variability. This paradigm relies on site-specific reliability tests before every deployment, followed by regular and recurrent checks throughout the life cycle of the deployed algorithm. Initial and recurrent reliability tests protect against performance-disruptive distribution shifts, and concept drifts that jeopardize patient safety.

Introduction: Increasing interest in real-world evidence has fueled the development of study designs incorporating real-world data (RWD). Using the Causal Roadmap, we specify three designs to evaluate the difference in risk of major adverse cardiovascular events (MACE) with oral semaglutide versus standard-of-care: 1) the actual sequence of non-inferiority and superiority randomized controlled trials (RCTs), 2) a single RCT, and 3) a hybrid randomized-external data study. Methods: The hybrid design considers integration of the PIONEER 6 RCT with RWD controls using the experiment-selector cross-validated targeted maximum likelihood estimator. We evaluate 95% confidence interval coverage, power, and average patient-time during which participants would be precluded from receiving a glucagon-like peptide-1 receptor agonist (GLP1-RA) for each design using simulations. Finally, we estimate the effect of oral semaglutide on MACE for the hybrid PIONEER 6-RWD analysis. Results: In simulations, Designs 1 and 2 performed similarly. The tradeoff between decreased coverage and patient-time without the possibility of a GLP1-RA for Designs 1 and 3 depended on the simulated bias. In real data analysis using Design 3, external controls were integrated in 84% of cross-validation folds, resulting in an estimated risk difference of -1.53%-points (95% CI -2.75%-points to -0.30%-points). Conclusions: The Causal Roadmap helps investigators to minimize potential bias in studies using RWD and to quantify tradeoffs between study designs. The simulation results help to interpret the level of evidence provided by the real data analysis in support of the superiority of oral semaglutide versus standard-of-care for cardiovascular risk reduction.

The use of deep learning approaches for image reconstruction is of contemporary interest in radiology, especially for approaches that solve inverse problems associated with imaging. In deployment, these models may be exposed to input distributions that are widely shifted from training data, due in part to data biases or drifts. We propose a metric based on local Lipschitz determined from a single trained model that can be used to estimate the model uncertainty for image reconstructions. We demonstrate a monotonic relationship between the local Lipschitz value and Mean Absolute Error and show that this method can be used to provide a threshold that determines whether a given DL reconstruction approach was well suited to the task. Our uncertainty estimation method can be used to identify out-of-distribution test samples, relate information regarding epistemic uncertainties, and guide proper data augmentation. Quantifying uncertainty of learned reconstruction approaches is especially pertinent to the medical domain where reconstructed images must remain diagnostically accurate.

While Reinforcement Learning (RL) achieves tremendous success in sequential decision-making problems of many domains, it still faces key challenges of data inefficiency and the lack of interpretability. Interestingly, many researchers have leveraged insights from the causality literature recently, bringing forth flourishing works to unify the merits of causality and address well the challenges from RL. As such, it is of great necessity and significance to collate these Causal Reinforcement Learning (CRL) works, offer a review of CRL methods, and investigate the potential functionality from causality toward RL. In particular, we divide existing CRL approaches into two categories according to whether their causality-based information is given in advance or not. We further analyze each category in terms of the formalization of different models, ranging from the Markov Decision Process (MDP), Partially Observed Markov Decision Process (POMDP), Multi-Arm Bandits (MAB), and Dynamic Treatment Regime (DTR). Moreover, we summarize the evaluation matrices and open sources while we discuss emerging applications, along with promising prospects for the future development of CRL.

In large-scale systems there are fundamental challenges when centralised techniques are used for task allocation. The number of interactions is limited by resource constraints such as on computation, storage, and network communication. We can increase scalability by implementing the system as a distributed task-allocation system, sharing tasks across many agents. However, this also increases the resource cost of communications and synchronisation, and is difficult to scale. In this paper we present four algorithms to solve these problems. The combination of these algorithms enable each agent to improve their task allocation strategy through reinforcement learning, while changing how much they explore the system in response to how optimal they believe their current strategy is, given their past experience. We focus on distributed agent systems where the agents' behaviours are constrained by resource usage limits, limiting agents to local rather than system-wide knowledge. We evaluate these algorithms in a simulated environment where agents are given a task composed of multiple subtasks that must be allocated to other agents with differing capabilities, to then carry out those tasks. We also simulate real-life system effects such as networking instability. Our solution is shown to solve the task allocation problem to 6.7% of the theoretical optimal within the system configurations considered. It provides 5x better performance recovery over no-knowledge retention approaches when system connectivity is impacted, and is tested against systems up to 100 agents with less than a 9% impact on the algorithms' performance.

Deep neural network architectures have traditionally been designed and explored with human expertise in a long-lasting trial-and-error process. This process requires huge amount of time, expertise, and resources. To address this tedious problem, we propose a novel algorithm to optimally find hyperparameters of a deep network architecture automatically. We specifically focus on designing neural architectures for medical image segmentation task. Our proposed method is based on a policy gradient reinforcement learning for which the reward function is assigned a segmentation evaluation utility (i.e., dice index). We show the efficacy of the proposed method with its low computational cost in comparison with the state-of-the-art medical image segmentation networks. We also present a new architecture design, a densely connected encoder-decoder CNN, as a strong baseline architecture to apply the proposed hyperparameter search algorithm. We apply the proposed algorithm to each layer of the baseline architectures. As an application, we train the proposed system on cine cardiac MR images from Automated Cardiac Diagnosis Challenge (ACDC) MICCAI 2017. Starting from a baseline segmentation architecture, the resulting network architecture obtains the state-of-the-art results in accuracy without performing any trial-and-error based architecture design approaches or close supervision of the hyperparameters changes.