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Restoring limb motor function in individuals with spinal cord injury (SCI), stroke, or amputation remains a critical challenge, one which affects millions worldwide. Recent studies show through surface electromyography (EMG) that spared motor neurons can still be voluntarily controlled, even without visible limb movement . These signals can be decoded and used for motor intent estimation; however, current wearable solutions lack the necessary hardware and software for intuitive interfacing of the spared degrees of freedom after neural injuries. To address these limitations, we developed a wireless, high-density EMG bracelet, coupled with a novel software framework, MyoGestic. Our system allows rapid and tailored adaptability of machine learning models to the needs of the users, facilitating real-time decoding of multiple spared distinctive degrees of freedom. In our study, we successfully decoded the motor intent from two participants with SCI, two with spinal stroke , and three amputees in real-time, achieving several controllable degrees of freedom within minutes after wearing the EMG bracelet. We provide a proof-of-concept that these decoded signals can be used to control a digitally rendered hand, a wearable orthosis, a prosthesis, or a 2D cursor. Our framework promotes a participant-centered approach, allowing immediate feedback integration, thus enhancing the iterative development of myocontrol algorithms. The proposed open-source software framework, MyoGestic, allows researchers and patients to focus on the augmentation and training of the spared degrees of freedom after neural lesions, thus potentially bridging the gap between research and clinical application and advancing the development of intuitive EMG interfaces for diverse neural lesions.

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Recently, there is growing demand for effective and efficient long sequence modeling, with State Space Models (SSMs) proving to be effective for long sequence tasks. To further reduce energy consumption, SSMs can be adapted to Spiking Neural Networks (SNNs) using spiking functions. However, current spiking-formalized SSMs approaches still rely on float-point matrix-vector multiplication during inference, undermining SNNs' energy advantage. In this work, we address the efficiency and performance challenges of long sequence learning in SNNs simultaneously. First, we propose a decoupled reset method for parallel spiking neuron training, reducing the typical Leaky Integrate-and-Fire (LIF) model's training time from $O(L^2)$ to $O(L\log L)$, effectively speeding up the training by $6.57 \times$ to $16.50 \times$ on sequence lengths $1,024$ to $32,768$. To our best knowledge, this is the first time that parallel computation with a reset mechanism is implemented achieving equivalence to its sequential counterpart. Secondly, to capture long-range dependencies, we propose a Parallel Resonate and Fire (PRF) neuron, which leverages an oscillating membrane potential driven by a resonate mechanism from a differentiable reset function in the complex domain. The PRF enables efficient long sequence learning while maintaining parallel training. Finally, we demonstrate that the proposed spike-driven architecture using PRF achieves performance comparable to Structured SSMs (S4), with two orders of magnitude reduction in energy consumption, outperforming Transformer on Long Range Arena tasks.

Stroke patients with upper limb motor impairments are re-acclimated to their corresponding motor functionalities through therapeutic interventions. Physiotherapists typically assess these functionalities using various qualitative protocols. However, such assessments are often biased and prone to errors, reducing rehabilitation efficacy. Therefore, real-time visualization and quantitative analysis of performance metrics, such as range of motion, repetition rate, velocity, etc., are crucial for accurate progress assessment. This study introduces Renovo, a working prototype of a wearable motion sensor-based assistive technology that assists physiotherapists with real-time visualization of these metrics. We also propose a novel mathematical framework for generating quantitative performance scores without relying on any machine learning model. We present the results of a three-week pilot study involving 16 stroke patients with upper limb disabilities, evaluated across three successive sessions at one-week intervals by both Renovo and physiotherapists (N=5). Results suggest that while the expertise of a physiotherapist is irreplaceable, Renovo can assist in the decision-making process by providing valuable quantitative information.

With the massive advancements in processing power, Digital Twins (DTs) have become powerful tools to monitor and analyze physical entities. However, due to the potentially very high number of Physical Systems (PSs) to be tracked and emulated, for instance, in a factory environment or an Internet of Things (IoT) network, continuous twinning might become infeasible. In this paper, a DT system is investigated with a set of random PSs, where the twinning rate is limited due to resource constraints. Three cost functions are considered to quantify and penalize the twinning delay. For these cost functions, the optimal twinning problem under twinning rate constraints is formulated. In a numerical example, the proposed cost functions are evaluated for two, one push-based and one pull-based, benchmark twinning policies. The proposed methodology is the first to investigate the optimal twinning problem with random PSs and twinning rate constraints, and serves as a guideline for real-world implementations on how frequently PSs should be twinned.

Symbolic regression (SR) is a powerful machine learning approach that searches for both the structure and parameters of algebraic models, offering interpretable and compact representations of complex data. Unlike traditional regression methods, SR explores progressively complex feature spaces, which can uncover simple models that generalize well, even from small datasets. Among SR algorithms, the Sure Independence Screening and Sparsifying Operator (SISSO) has proven particularly effective in the natural sciences, helping to rediscover fundamental physical laws as well as discover new interpretable equations for materials property modeling. However, its widespread adoption has been limited by performance inefficiencies and the challenges posed by its FORTRAN-based implementation, especially in modern computing environments. In this work, we introduce TorchSISSO, a native Python implementation built in the PyTorch framework. TorchSISSO leverages GPU acceleration, easy integration, and extensibility, offering a significant speed-up and improved accuracy over the original. We demonstrate that TorchSISSO matches or exceeds the performance of the original SISSO across a range of tasks, while dramatically reducing computational time and improving accessibility for broader scientific applications.

Maintaining numerical stability in machine learning models is crucial for their reliability and performance. One approach to maintain stability of a network layer is to integrate the condition number of the weight matrix as a regularizing term into the optimization algorithm. However, due to its discontinuous nature and lack of differentiability the condition number is not suitable for a gradient descent approach. This paper introduces a novel regularizer that is provably differentiable almost everywhere and promotes matrices with low condition numbers. In particular, we derive a formula for the gradient of this regularizer which can be easily implemented and integrated into existing optimization algorithms. We show the advantages of this approach for noisy classification and denoising of MNIST images.

Various kinds of uncertainty can occur in event logs, e.g., due to flawed recording, data quality issues, or the use of probabilistic models for activity recognition. Stochastically known event logs make these uncertainties transparent by encoding multiple possible realizations for events. However, the number of realizations encoded by a stochastically known log grows exponentially with its size, making exhaustive exploration infeasible even for moderately sized event logs. Thus, considering only the top-K most probable realizations has been proposed in the literature. In this paper, we implement an efficient algorithm to calculate a top-K realization ranking of an event log under event independence within O(Kn), where n is the number of uncertain events in the log. This algorithm is used to investigate the benefit of top-K rankings over top-1 interpretations of stochastically known event logs. Specifically, we analyze the usefulness of top-K rankings against different properties of the input data. We show that the benefit of a top-K ranking depends on the length of the input event log and the distribution of the event probabilities. The results highlight the potential of top-K rankings to enhance uncertainty-aware process mining techniques.

The fusion of causal models with deep learning introducing increasingly intricate data sets, such as the causal associations within images or between textual components, has surfaced as a focal research area. Nonetheless, the broadening of original causal concepts and theories to such complex, non-statistical data has been met with serious challenges. In response, our study proposes redefinitions of causal data into three distinct categories from the standpoint of causal structure and representation: definite data, semi-definite data, and indefinite data. Definite data chiefly pertains to statistical data used in conventional causal scenarios, while semi-definite data refers to a spectrum of data formats germane to deep learning, including time-series, images, text, and others. Indefinite data is an emergent research sphere inferred from the progression of data forms by us. To comprehensively present these three data paradigms, we elaborate on their formal definitions, differences manifested in datasets, resolution pathways, and development of research. We summarize key tasks and achievements pertaining to definite and semi-definite data from myriad research undertakings, present a roadmap for indefinite data, beginning with its current research conundrums. Lastly, we classify and scrutinize the key datasets presently utilized within these three paradigms.

Ensuring alignment, which refers to making models behave in accordance with human intentions [1,2], has become a critical task before deploying large language models (LLMs) in real-world applications. For instance, OpenAI devoted six months to iteratively aligning GPT-4 before its release [3]. However, a major challenge faced by practitioners is the lack of clear guidance on evaluating whether LLM outputs align with social norms, values, and regulations. This obstacle hinders systematic iteration and deployment of LLMs. To address this issue, this paper presents a comprehensive survey of key dimensions that are crucial to consider when assessing LLM trustworthiness. The survey covers seven major categories of LLM trustworthiness: reliability, safety, fairness, resistance to misuse, explainability and reasoning, adherence to social norms, and robustness. Each major category is further divided into several sub-categories, resulting in a total of 29 sub-categories. Additionally, a subset of 8 sub-categories is selected for further investigation, where corresponding measurement studies are designed and conducted on several widely-used LLMs. The measurement results indicate that, in general, more aligned models tend to perform better in terms of overall trustworthiness. However, the effectiveness of alignment varies across the different trustworthiness categories considered. This highlights the importance of conducting more fine-grained analyses, testing, and making continuous improvements on LLM alignment. By shedding light on these key dimensions of LLM trustworthiness, this paper aims to provide valuable insights and guidance to practitioners in the field. Understanding and addressing these concerns will be crucial in achieving reliable and ethically sound deployment of LLMs in various applications.

In pace with developments in the research field of artificial intelligence, knowledge graphs (KGs) have attracted a surge of interest from both academia and industry. As a representation of semantic relations between entities, KGs have proven to be particularly relevant for natural language processing (NLP), experiencing a rapid spread and wide adoption within recent years. Given the increasing amount of research work in this area, several KG-related approaches have been surveyed in the NLP research community. However, a comprehensive study that categorizes established topics and reviews the maturity of individual research streams remains absent to this day. Contributing to closing this gap, we systematically analyzed 507 papers from the literature on KGs in NLP. Our survey encompasses a multifaceted review of tasks, research types, and contributions. As a result, we present a structured overview of the research landscape, provide a taxonomy of tasks, summarize our findings, and highlight directions for future work.

We propose a novel attention gate (AG) model for medical imaging that automatically learns to focus on target structures of varying shapes and sizes. Models trained with AGs implicitly learn to suppress irrelevant regions in an input image while highlighting salient features useful for a specific task. This enables us to eliminate the necessity of using explicit external tissue/organ localisation modules of cascaded convolutional neural networks (CNNs). AGs can be easily integrated into standard CNN architectures such as the U-Net model with minimal computational overhead while increasing the model sensitivity and prediction accuracy. The proposed Attention U-Net architecture is evaluated on two large CT abdominal datasets for multi-class image segmentation. Experimental results show that AGs consistently improve the prediction performance of U-Net across different datasets and training sizes while preserving computational efficiency. The code for the proposed architecture is publicly available.

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