In Vitro Fertilization (IVF) is the most widely used Assisted Reproductive Technology (ART). IVF usually involves controlled ovarian stimulation, oocyte retrieval, fertilization in the laboratory with subsequent embryo transfer. The first two steps correspond with follicular phase of females and ovulation in their menstrual cycle. Therefore, we refer to it as the treatment cycle in our paper. The treatment cycle is crucial because the stimulation medications in IVF treatment are applied directly on patients. In order to optimize the stimulation effects and lower the side effects of the stimulation medications, prompt treatment adjustments are in need. In addition, the quality and quantity of the retrieved oocytes have a significant effect on the outcome of the following procedures. To improve the IVF success rate, we propose a knowledge-based decision support system that can provide medical advice on the treatment protocol and medication adjustment for each patient visit during IVF treatment cycle. Our system is efficient in data processing and light-weighted which can be easily embedded into electronic medical record systems. Moreover, an oocyte retrieval oriented evaluation demonstrates that our system performs well in terms of accuracy of advice for the protocols and medications.
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The growing complexity of Cyber-Physical Systems (CPS) and challenges in ensuring safety and security have led to the increasing use of deep learning methods for accurate and scalable anomaly detection. However, machine learning (ML) models often suffer from low performance in predicting unexpected data and are vulnerable to accidental or malicious perturbations. Although robustness testing of deep learning models has been extensively explored in applications such as image classification and speech recognition, less attention has been paid to ML-driven safety monitoring in CPS. This paper presents the preliminary results on evaluating the robustness of ML-based anomaly detection methods in safety-critical CPS against two types of accidental and malicious input perturbations, generated using a Gaussian-based noise model and the Fast Gradient Sign Method (FGSM). We test the hypothesis of whether integrating the domain knowledge (e.g., on unsafe system behavior) with the ML models can improve the robustness of anomaly detection without sacrificing accuracy and transparency. Experimental results with two case studies of Artificial Pancreas Systems (APS) for diabetes management show that ML-based safety monitors trained with domain knowledge can reduce on average up to 54.2% of robustness error and keep the average F1 scores high while improving transparency.
Gaussian Process (GP) emulators are widely used to approximate complex computer model behaviour across the input space. Motivated by the problem of coupling computer models, recently progress has been made in the theory of the analysis of networks of connected GP emulators. In this paper, we combine these recent methodological advances with classical state-space models to construct a Bayesian decision support system. This approach gives a coherent probability model that produces predictions with the measure of uncertainty in terms of two first moments and enables the propagation of uncertainty from individual decision components. This methodology is used to produce a decision support tool for a UK county council considering low carbon technologies to transform its infrastructure to reach a net-zero carbon target. In particular, we demonstrate how to couple information from an energy model, a heating demand model, and gas and electricity price time-series to quantitatively assess the impact on operational costs of various policy choices and changes in the energy market.
Linear mixed models (LMMs) are instrumental for regression analysis with structured dependence, such as grouped, clustered, or multilevel data. However, selection among the covariates--while accounting for this structured dependence--remains a challenge. We introduce a Bayesian decision analysis for subset selection with LMMs. Using a Mahalanobis loss function that incorporates the structured dependence, we derive optimal linear coefficients for (i) any given subset of variables and (ii) all subsets of variables that satisfy a cardinality constraint. Crucially, these estimates inherit shrinkage or regularization and uncertainty quantification from the underlying Bayesian model, and apply for any well-specified Bayesian LMM. More broadly, our decision analysis strategy deemphasizes the role of a single "best" subset, which is often unstable and limited in its information content, and instead favors a collection of near-optimal subsets. This collection is summarized by key member subsets and variable-specific importance metrics. Customized subset search and out-of-sample approximation algorithms are provided for more scalable computing. These tools are applied to simulated data and a longitudinal physical activity dataset, and demonstrate excellent prediction, estimation, and selection ability.
Annotating data for supervised learning can be costly. When the annotation budget is limited, active learning can be used to select and annotate those observations that are likely to give the most gain in model performance. We propose an active learning algorithm that, in addition to selecting which observation to annotate, selects the precision of the annotation that is acquired. Assuming that annotations with low precision are cheaper to obtain, this allows the model to explore a larger part of the input space, with the same annotation costs. We build our acquisition function on the previously proposed BALD objective for Gaussian Processes, and empirically demonstrate the gains of being able to adjust the annotation precision in the active learning loop.
To diversify and enrich generated dialogue responses, knowledge-grounded dialogue has been investigated in recent years. The existing methods tackle the knowledge grounding challenge by retrieving the relevant sentences over a large corpus and augmenting the dialogues with explicit extra information. Despite their success, however, the existing works have drawbacks on the inference efficiency. This paper proposes KnowExpert, an end-to-end framework to bypass the explicit retrieval process and inject knowledge into the pre-trained language models with lightweight adapters and adapt to the knowledge-grounded dialogue task. To the best of our knowledge, this is the first attempt to tackle this challenge without retrieval in this task under an open-domain chit-chat scenario. The experimental results show that KknowExpert performs comparably with some retrieval-based baselines while being time-efficient in inference, demonstrating the potential of our proposed direction.
The increase and rapid growth of data produced by scientific instruments, the Internet of Things (IoT), and social media is causing data transfer performance and resource consumption to garner much attention in the research community. The network infrastructure and end systems that enable this extensive data movement use a substantial amount of electricity, measured in terawatt-hours per year. Managing energy consumption within the core networking infrastructure is an active research area, but there is a limited amount of work on reducing power consumption at the end systems during active data transfers. This paper presents a novel two-phase dynamic throughput and energy optimization model that utilizes an offline decision-search-tree based clustering technique to encapsulate and categorize historical data transfer log information and an online search optimization algorithm to find the best application and kernel layer parameter combination to maximize the achieved data transfer throughput while minimizing the energy consumption. Our model also incorporates an ensemble method to reduce aleatoric uncertainty in finding optimal application and kernel layer parameters during the offline analysis phase. The experimental evaluation results show that our decision-tree based model outperforms the state-of-the-art solutions in this area by achieving 117% higher throughput on average and also consuming 19% less energy at the end systems during active data transfers.
Early Myocardial Infarction Detection with One-Class Classification over Multi-view Echocardiography
Myocardial infarction (MI) is the leading cause of mortality and morbidity in the world. Early therapeutics of MI can ensure the prevention of further myocardial necrosis. Echocardiography is the fundamental imaging technique that can reveal the earliest sign of MI. However, the scarcity of echocardiographic datasets for the MI detection is the major issue for training data-driven classification algorithms. In this study, we propose a framework for early detection of MI over multi-view echocardiography that leverages one-class classification (OCC) techniques. The OCC techniques are used to train a model for detecting a specific target class using instances from that particular category only. We investigated the usage of uni-modal and multi-modal one-class classification techniques in the proposed framework using the HMC-QU dataset that includes apical 4-chamber (A4C) and apical 2-chamber (A2C) views in a total of 260 echocardiography recordings. Experimental results show that the multi-modal approach achieves a sensitivity level of 85.23% and F1-Score of 80.21%.
Medical Visual Question Answering (VQA) is a combination of medical artificial intelligence and popular VQA challenges. Given a medical image and a clinically relevant question in natural language, the medical VQA system is expected to predict a plausible and convincing answer. Although the general-domain VQA has been extensively studied, the medical VQA still needs specific investigation and exploration due to its task features. In the first part of this survey, we cover and discuss the publicly available medical VQA datasets up to date about the data source, data quantity, and task feature. In the second part, we review the approaches used in medical VQA tasks. In the last part, we analyze some medical-specific challenges for the field and discuss future research directions.
Most algorithms for representation learning and link prediction in relational data have been designed for static data. However, the data they are applied to usually evolves with time, such as friend graphs in social networks or user interactions with items in recommender systems. This is also the case for knowledge bases, which contain facts such as (US, has president, B. Obama, [2009-2017]) that are valid only at certain points in time. For the problem of link prediction under temporal constraints, i.e., answering queries such as (US, has president, ?, 2012), we propose a solution inspired by the canonical decomposition of tensors of order 4. We introduce new regularization schemes and present an extension of ComplEx (Trouillon et al., 2016) that achieves state-of-the-art performance. Additionally, we propose a new dataset for knowledge base completion constructed from Wikidata, larger than previous benchmarks by an order of magnitude, as a new reference for evaluating temporal and non-temporal link prediction methods.
To solve the information explosion problem and enhance user experience in various online applications, recommender systems have been developed to model users preferences. Although numerous efforts have been made toward more personalized recommendations, recommender systems still suffer from several challenges, such as data sparsity and cold start. In recent years, generating recommendations with the knowledge graph as side information has attracted considerable interest. Such an approach can not only alleviate the abovementioned issues for a more accurate recommendation, but also provide explanations for recommended items. In this paper, we conduct a systematical survey of knowledge graph-based recommender systems. We collect recently published papers in this field and summarize them from two perspectives. On the one hand, we investigate the proposed algorithms by focusing on how the papers utilize the knowledge graph for accurate and explainable recommendation. On the other hand, we introduce datasets used in these works. Finally, we propose several potential research directions in this field.
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