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In this paper, we explore the challenges associated with biomarker identification for diagnosis purpose in biomedical experiments, and propose a novel approach to handle the above challenging scenario via the generalization of the Dantzig selector. To improve the efficiency of the regularization method, we introduce a transformation from an inherent nonlinear programming due to its nonlinear link function into a linear programming framework. We illustrate the use of of our method on an experiment with binary response, showing superior performance on biomarker identification studies when compared to their conventional analysis. Our proposed method does not merely serve as a variable/biomarker selection tool, its ranking of variable importance provides valuable reference information for practitioners to reach informed decisions regarding the prioritization of factors for further investigations.

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In this paper, we propose an information geometry approach (IGA) for signal detection (SD) in ultra-massive multiple-input multiple-output (MIMO) systems. We formulate the signal detection as obtaining the marginals of the a posteriori probability distribution of the transmitted symbol vector. Then, a maximization of the a posteriori marginals (MPM) for signal detection can be performed. With the information geometry theory, we calculate the approximations of the a posteriori marginals. It is formulated as an iterative m-projection process between submanifolds with different constraints. We then apply the central-limit-theorem (CLT) to simplify the calculation of the m-projection since the direct calculation of the m-projection is of exponential-complexity. With the CLT, we obtain an approximate solution of the m-projection, which is asymptotically accurate. Simulation results demonstrate that the proposed IGA-SD emerges as a promising and efficient method to implement the signal detector in ultra-massive MIMO systems.

Recently, brain-inspired spiking neural networks (SNNs) have demonstrated promising capabilities in solving pattern recognition tasks. However, these SNNs are grounded on homogeneous neurons that utilize a uniform neural coding for information representation. Given that each neural coding scheme possesses its own merits and drawbacks, these SNNs encounter challenges in achieving optimal performance such as accuracy, response time, efficiency, and robustness, all of which are crucial for practical applications. In this study, we argue that SNN architectures should be holistically designed to incorporate heterogeneous coding schemes. As an initial exploration in this direction, we propose a hybrid neural coding and learning framework, which encompasses a neural coding zoo with diverse neural coding schemes discovered in neuroscience. Additionally, it incorporates a flexible neural coding assignment strategy to accommodate task-specific requirements, along with novel layer-wise learning methods to effectively implement hybrid coding SNNs. We demonstrate the superiority of the proposed framework on image classification and sound localization tasks. Specifically, the proposed hybrid coding SNNs achieve comparable accuracy to state-of-the-art SNNs, while exhibiting significantly reduced inference latency and energy consumption, as well as high noise robustness. This study yields valuable insights into hybrid neural coding designs, paving the way for developing high-performance neuromorphic systems.

In this paper, we solve the optimal target detection problem employing the thoughts and methodologies of Shannon's information theory. Introducing a target state variable into a general radar system model, an equivalent detection channel is derived, and the a posteriori probability distribution is given accordingly. Detection information (DI) is proposed for measuring system performance, which holds for any specific detection method. Moreover, we provide an analytic expression for the false alarm probability concerning the a priori probability. In particular, for a sufficiently large observation interval, the false alarm probability equals the a priori probability of the existing state. A stochastic detection method, the sampling a posteriori probability, is also proposed. The target detection theorem is proved mathematically, which indicates that DI is an achievable theoretical limit of target detection. Specifically, when empirical DI is gained from the sampling a posteriori detection method approaches the DI, the probability of failed decisions tends to be zero. Conversely, there is no detector whose empirical DI is more than DI. Numerical simulations are performed to verify the correctness of the theorems. The results demonstrate that the maximum a posteriori and the Neyman-Pearson detection methods are upper bounded by the theoretical limit.

In this paper, we investigate on improving the adversarial robustness obtained in adversarial training (AT) via reducing the difficulty of optimization. To better study this problem, we build a novel Bregman divergence perspective for AT, in which AT can be viewed as the sliding process of the training data points on the negative entropy curve. Based on this perspective, we analyze the learning objectives of two typical AT methods, i.e., PGD-AT and TRADES, and we find that the optimization process of TRADES is easier than PGD-AT for that TRADES separates PGD-AT. In addition, we discuss the function of entropy in TRADES, and we find that models with high entropy can be better robustness learners. Inspired by the above findings, we propose two methods, i.e., FAIT and MER, which can both not only reduce the difficulty of optimization under the 10-step PGD adversaries, but also provide better robustness. Our work suggests that reducing the difficulty of optimization under the 10-step PGD adversaries is a promising approach for enhancing the adversarial robustness in AT.

In this paper, we propose a novel method for joint entity and relation extraction from unstructured text by framing it as a conditional sequence generation problem. In contrast to conventional generative information extraction models that are left-to-right token-level generators, our approach is \textit{span-based}. It generates a linearized graph where nodes represent text spans and edges represent relation triplets. Our method employs a transformer encoder-decoder architecture with pointing mechanism on a dynamic vocabulary of spans and relation types. Our model can capture the structural characteristics and boundaries of entities and relations through span representations while simultaneously grounding the generated output in the original text thanks to the pointing mechanism. Evaluation on benchmark datasets validates the effectiveness of our approach, demonstrating competitive results. Code is available at //github.com/urchade/ATG.

In the era of precision medicine, more and more clinical trials are now driven or guided by biomarkers, which are patient characteristics objectively measured and evaluated as indicators of normal biological processes, pathogenic processes, or pharmacologic responses to therapeutic interventions. With the overarching objective to optimize and personalize disease management, biomarker-guided clinical trials increase the efficiency by appropriately utilizing prognostic or predictive biomarkers in the design. However, the efficiency gain is often not quantitatively compared to the traditional all-comers design, in which a faster enrollment rate is expected (e.g. due to no restriction to biomarker positive patients) potentially leading to a shorter duration. To accurately predict biomarker-guided trial duration, we propose a general framework using mixture distributions accounting for heterogeneous population. Extensive simulations are performed to evaluate the impact of heterogeneous population and the dynamics of biomarker characteristics and disease on the study duration. Several influential parameters including median survival time, enrollment rate, biomarker prevalence and effect size are identitied. Re-assessments of two publicly available trials are conducted to empirically validate the prediction accuracy and to demonstrate the practical utility. The R package \emph{detest} is developed to implement the proposed method and is publicly available on CRAN.

In this paper, we propose a novel Feature Decomposition and Reconstruction Learning (FDRL) method for effective facial expression recognition. We view the expression information as the combination of the shared information (expression similarities) across different expressions and the unique information (expression-specific variations) for each expression. More specifically, FDRL mainly consists of two crucial networks: a Feature Decomposition Network (FDN) and a Feature Reconstruction Network (FRN). In particular, FDN first decomposes the basic features extracted from a backbone network into a set of facial action-aware latent features to model expression similarities. Then, FRN captures the intra-feature and inter-feature relationships for latent features to characterize expression-specific variations, and reconstructs the expression feature. To this end, two modules including an intra-feature relation modeling module and an inter-feature relation modeling module are developed in FRN. Experimental results on both the in-the-lab databases (including CK+, MMI, and Oulu-CASIA) and the in-the-wild databases (including RAF-DB and SFEW) show that the proposed FDRL method consistently achieves higher recognition accuracy than several state-of-the-art methods. This clearly highlights the benefit of feature decomposition and reconstruction for classifying expressions.

Human doctors with well-structured medical knowledge can diagnose a disease merely via a few conversations with patients about symptoms. In contrast, existing knowledge-grounded dialogue systems often require a large number of dialogue instances to learn as they fail to capture the correlations between different diseases and neglect the diagnostic experience shared among them. To address this issue, we propose a more natural and practical paradigm, i.e., low-resource medical dialogue generation, which can transfer the diagnostic experience from source diseases to target ones with a handful of data for adaptation. It is capitalized on a commonsense knowledge graph to characterize the prior disease-symptom relations. Besides, we develop a Graph-Evolving Meta-Learning (GEML) framework that learns to evolve the commonsense graph for reasoning disease-symptom correlations in a new disease, which effectively alleviates the needs of a large number of dialogues. More importantly, by dynamically evolving disease-symptom graphs, GEML also well addresses the real-world challenges that the disease-symptom correlations of each disease may vary or evolve along with more diagnostic cases. Extensive experiment results on the CMDD dataset and our newly-collected Chunyu dataset testify the superiority of our approach over state-of-the-art approaches. Besides, our GEML can generate an enriched dialogue-sensitive knowledge graph in an online manner, which could benefit other tasks grounded on knowledge graph.

In this paper, we introduce the Reinforced Mnemonic Reader for machine reading comprehension tasks, which enhances previous attentive readers in two aspects. First, a reattention mechanism is proposed to refine current attentions by directly accessing to past attentions that are temporally memorized in a multi-round alignment architecture, so as to avoid the problems of attention redundancy and attention deficiency. Second, a new optimization approach, called dynamic-critical reinforcement learning, is introduced to extend the standard supervised method. It always encourages to predict a more acceptable answer so as to address the convergence suppression problem occurred in traditional reinforcement learning algorithms. Extensive experiments on the Stanford Question Answering Dataset (SQuAD) show that our model achieves state-of-the-art results. Meanwhile, our model outperforms previous systems by over 6% in terms of both Exact Match and F1 metrics on two adversarial SQuAD datasets.

In this paper, we propose the joint learning attention and recurrent neural network (RNN) models for multi-label classification. While approaches based on the use of either model exist (e.g., for the task of image captioning), training such existing network architectures typically require pre-defined label sequences. For multi-label classification, it would be desirable to have a robust inference process, so that the prediction error would not propagate and thus affect the performance. Our proposed model uniquely integrates attention and Long Short Term Memory (LSTM) models, which not only addresses the above problem but also allows one to identify visual objects of interests with varying sizes without the prior knowledge of particular label ordering. More importantly, label co-occurrence information can be jointly exploited by our LSTM model. Finally, by advancing the technique of beam search, prediction of multiple labels can be efficiently achieved by our proposed network model.

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