As advancements in artificial intelligence propel progress in the life sciences, they may also enable the weaponisation and misuse of biological agents. This article differentiates two classes of AI tools that pose such biosecurity risks: large language models (LLMs) and biological design tools (BDTs). LLMs, such as GPT-4, are already able to provide dual-use information that could have enabled historical biological weapons efforts to succeed. As LLMs are turned into lab assistants and autonomous science tools, this will further increase their ability to support research. Thus, LLMs will in particular lower barriers to biological misuse. In contrast, BDTs will expand the capabilities of sophisticated actors. Concretely, BDTs may enable the creation of pandemic pathogens substantially worse than anything seen to date and could enable forms of more predictable and targeted biological weapons. In combination, LLMs and BDTs could raise the ceiling of harm from biological agents and could make them broadly accessible. The differing risk profiles of LLMs and BDTs have important implications for risk mitigation. LLM risks require urgent action and might be effectively mitigated by controlling access to dangerous capabilities. Mandatory pre-release evaluations could be critical to ensure that developers eliminate dangerous capabilities. Science-specific AI tools demand differentiated strategies to allow access to legitimate users while preventing misuse. Meanwhile, risks from BDTs are less defined and require monitoring by developers and policymakers. Key to reducing these risks will be enhanced screening of gene synthesis, interventions to deter biological misuse by sophisticated actors, and exploration of specific controls of BDTs.
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In light of the increasing adoption of edge computing in areas such as intelligent furniture, robotics, and smart homes, this paper introduces HyperSNN, an innovative method for control tasks that uses spiking neural networks (SNNs) in combination with hyperdimensional computing. HyperSNN substitutes expensive 32-bit floating point multiplications with 8-bit integer additions, resulting in reduced energy consumption while enhancing robustness and potentially improving accuracy. Our model was tested on AI Gym benchmarks, including Cartpole, Acrobot, MountainCar, and Lunar Lander. HyperSNN achieves control accuracies that are on par with conventional machine learning methods but with only 1.36% to 9.96% of the energy expenditure. Furthermore, our experiments showed increased robustness when using HyperSNN. We believe that HyperSNN is especially suitable for interactive, mobile, and wearable devices, promoting energy-efficient and robust system design. Furthermore, it paves the way for the practical implementation of complex algorithms like model predictive control (MPC) in real-world industrial scenarios.
Humans can produce complex whole-body motions when interacting with their surroundings, by planning, executing and combining individual limb movements. We investigated this fundamental aspect of motor control in the setting of autonomous robotic operations. We approach this problem by hierarchical generative modelling equipped with multi-level planning-for autonomous task completion-that mimics the deep temporal architecture of human motor control. Here, temporal depth refers to the nested time scales at which successive levels of a forward or generative model unfold, for example, delivering an object requires a global plan to contextualise the fast coordination of multiple local movements of limbs. This separation of temporal scales also motivates robotics and control. Specifically, to achieve versatile sensorimotor control, it is advantageous to hierarchically structure the planning and low-level motor control of individual limbs. We use numerical and physical simulation to conduct experiments and to establish the efficacy of this formulation. Using a hierarchical generative model, we show how a humanoid robot can autonomously complete a complex task that necessitates a holistic use of locomotion, manipulation, and grasping. Specifically, we demonstrate the ability of a humanoid robot that can retrieve and transport a box, open and walk through a door to reach the destination, approach and kick a football, while showing robust performance in presence of body damage and ground irregularities. Our findings demonstrated the effectiveness of using human-inspired motor control algorithms, and our method provides a viable hierarchical architecture for the autonomous completion of challenging goal-directed tasks.
Matrices are built and designed by applying procedures from lower order matrices. Matrix tensor products, direct sums or multiplication of matrices are such procedures and a matrix built from these is said to be a {\em separable} matrix. A {\em non-separable} matrix is a matrix which is not separable and is often referred to as {\em an entangled matrix}. The matrices built may retain properties of the lower order matrices or may also acquire new desired properties not inherent in the constituents. Here design methods for non-separable matrices of required types are derived. These can retain properties of lower order matrices or have new desirable properties. Infinite series of required non-separable matrices are constructible by the general methods. Non-separable matrices are required for applications and other uses; they can capture the structure in a unique way and thus perform much better than separable matrices. General new methods are developed with which to construct {\em multidimensional entangled paraunitary matrices}; these have applications for wavelet and filter bank design. The constructions are in addition used to design new systems of non-separable unitary matrices; these have applications in quantum information theory. Some consequences include the design of full diversity constellations of unitary matrices, which are used in MIMO systems, and methods to design infinite series of special types of Hadamard matrices.
Making inference with spatial extremal dependence models can be computationally burdensome since they involve intractable and/or censored likelihoods. Building on recent advances in likelihood-free inference with neural Bayes estimators, that is, neural networks that approximate Bayes estimators, we develop highly efficient estimators for censored peaks-over-threshold models that encode censoring information in the neural network architecture. Our new method provides a paradigm shift that challenges traditional censored likelihood-based inference methods for spatial extremal dependence models. Our simulation studies highlight significant gains in both computational and statistical efficiency, relative to competing likelihood-based approaches, when applying our novel estimators to make inference with popular extremal dependence models, such as max-stable, $r$-Pareto, and random scale mixture process models. We also illustrate that it is possible to train a single neural Bayes estimator for a general censoring level, precluding the need to retrain the network when the censoring level is changed. We illustrate the efficacy of our estimators by making fast inference on hundreds-of-thousands of high-dimensional spatial extremal dependence models to assess extreme particulate matter 2.5 microns or less in diameter (PM2.5) concentration over the whole of Saudi Arabia.
Statistical models are at the heart of any empirical study for hypothesis testing. We present a new cross-platform Python-based package which employs different likelihood prescriptions through a plug-in system. This framework empowers users to propose, examine, and publish new likelihood prescriptions without developing software infrastructure, ultimately unifying and generalising different ways of constructing likelihoods and employing them for hypothesis testing, all in one place. Within this package, we propose a new simplified likelihood prescription that surpasses its predecessors' approximation accuracy by incorporating asymmetric uncertainties. Furthermore, our package facilitates the inclusion of various likelihood combination routines, thereby broadening the scope of independent studies through a meta-analysis. By remaining agnostic to the source of the likelihood prescription and the signal hypothesis generator, our platform allows for the seamless implementation of packages with different likelihood prescriptions, fostering compatibility and interoperability.
The development of large, software-intensive systems is a complex undertaking that we generally tackle by a divide and conquer strategy. Companies thereby face the challenge of coordinating individual aspects of software development, in particular between requirements engineering (RE) and software testing (ST). A lack of REST alignment can not only lead to wasted effort but also to defective software. However, before a company can improve the mechanisms of coordination they need to be understood first. With REST-bench we aim at providing an assessment tool that illustrates the coordination in software development projects and identify concrete improvement opportunities. We have developed REST-bench on the sound fundamentals of a taxonomy on REST alignment methods and validated the method in five case studies. Following the principles of technical action research, we collaborated with five companies, applying REST-bench and iteratively improving the method based on the lessons we learned. We applied REST-bench both in Agile and plan-driven environments, in projects lasting from weeks to years, and staffed as large as 1000 employees. The improvement opportunities we identified and the feedback we received indicate that the assessment was effective and efficient. Furthermore, participants confirmed that their understanding on the coordination between RE and ST improved.
Many models of learning in teams assume that team members can share solutions or learn concurrently. However, these assumptions break down in multidisciplinary teams where team members often complete distinct, interrelated pieces of larger tasks. Such contexts make it difficult for individuals to separate the performance effects of their own actions from the actions of interacting neighbors. In this work, we show that individuals can overcome this challenge by learning from network neighbors through mediating artifacts (like collective performance assessments). When neighbors' actions influence collective outcomes, teams with different networks perform relatively similarly to one another. However, varying a team's network can affect performance on tasks that weight individuals' contributions by network properties. Consequently, when individuals innovate (through ``exploring'' searches), dense networks hurt performance slightly by increasing uncertainty. In contrast, dense networks moderately help performance when individuals refine their work (through ``exploiting'' searches) by efficiently finding local optima. We also find that decentralization improves team performance across a battery of 34 tasks. Our results offer design principles for multidisciplinary teams within which other forms of learning prove more difficult.
Artificial neural networks thrive in solving the classification problem for a particular rigid task, acquiring knowledge through generalized learning behaviour from a distinct training phase. The resulting network resembles a static entity of knowledge, with endeavours to extend this knowledge without targeting the original task resulting in a catastrophic forgetting. Continual learning shifts this paradigm towards networks that can continually accumulate knowledge over different tasks without the need to retrain from scratch. We focus on task incremental classification, where tasks arrive sequentially and are delineated by clear boundaries. Our main contributions concern 1) a taxonomy and extensive overview of the state-of-the-art, 2) a novel framework to continually determine the stability-plasticity trade-off of the continual learner, 3) a comprehensive experimental comparison of 11 state-of-the-art continual learning methods and 4 baselines. We empirically scrutinize method strengths and weaknesses on three benchmarks, considering Tiny Imagenet and large-scale unbalanced iNaturalist and a sequence of recognition datasets. We study the influence of model capacity, weight decay and dropout regularization, and the order in which the tasks are presented, and qualitatively compare methods in terms of required memory, computation time, and storage.
Although measuring held-out accuracy has been the primary approach to evaluate generalization, it often overestimates the performance of NLP models, while alternative approaches for evaluating models either focus on individual tasks or on specific behaviors. Inspired by principles of behavioral testing in software engineering, we introduce CheckList, a task-agnostic methodology for testing NLP models. CheckList includes a matrix of general linguistic capabilities and test types that facilitate comprehensive test ideation, as well as a software tool to generate a large and diverse number of test cases quickly. We illustrate the utility of CheckList with tests for three tasks, identifying critical failures in both commercial and state-of-art models. In a user study, a team responsible for a commercial sentiment analysis model found new and actionable bugs in an extensively tested model. In another user study, NLP practitioners with CheckList created twice as many tests, and found almost three times as many bugs as users without it.
Recent advances in 3D fully convolutional networks (FCN) have made it feasible to produce dense voxel-wise predictions of volumetric images. In this work, we show that a multi-class 3D FCN trained on manually labeled CT scans of several anatomical structures (ranging from the large organs to thin vessels) can achieve competitive segmentation results, while avoiding the need for handcrafting features or training class-specific models. To this end, we propose a two-stage, coarse-to-fine approach that will first use a 3D FCN to roughly define a candidate region, which will then be used as input to a second 3D FCN. This reduces the number of voxels the second FCN has to classify to ~10% and allows it to focus on more detailed segmentation of the organs and vessels. We utilize training and validation sets consisting of 331 clinical CT images and test our models on a completely unseen data collection acquired at a different hospital that includes 150 CT scans, targeting three anatomical organs (liver, spleen, and pancreas). In challenging organs such as the pancreas, our cascaded approach improves the mean Dice score from 68.5 to 82.2%, achieving the highest reported average score on this dataset. We compare with a 2D FCN method on a separate dataset of 240 CT scans with 18 classes and achieve a significantly higher performance in small organs and vessels. Furthermore, we explore fine-tuning our models to different datasets. Our experiments illustrate the promise and robustness of current 3D FCN based semantic segmentation of medical images, achieving state-of-the-art results. Our code and trained models are available for download: //github.com/holgerroth/3Dunet_abdomen_cascade.
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