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Motivated by investigating the relationship between progesterone and the days in a menstrual cycle in a longitudinal study, we propose a multi-kink quantile regression model for longitudinal data analysis. It relaxes the linearity condition and assumes different regression forms in different regions of the domain of the threshold covariate. In this paper, we first propose a multi-kink quantile regression for longitudinal data. Two estimation procedures are proposed to estimate the regression coefficients and the kink points locations: one is a computationally efficient profile estimator under the working independence framework while the other one considers the within-subject correlations by using the unbiased generalized estimation equation approach. The selection consistency of the number of kink points and the asymptotic normality of two proposed estimators are established. Secondly, we construct a rank score test based on partial subgradients for the existence of kink effect in longitudinal studies. Both the null distribution and the local alternative distribution of the test statistic have been derived. Simulation studies show that the proposed methods have excellent finite sample performance. In the application to the longitudinal progesterone data, we identify two kink points in the progesterone curves over different quantiles and observe that the progesterone level remains stable before the day of ovulation, then increases quickly in five to six days after ovulation and then changes to stable again or even drops slightly

Suppose we are interested in the effect of a treatment in a clinical trial. The efficiency of inference may be limited due to small sample size. However, external control data are often available from historical studies. Motivated by an application to Helicobacter pylori infection, we show how to borrow strength from such data to improve efficiency of inference in the clinical trial. Under an exchangeability assumption about the potential outcome mean, we show that the semiparametric efficiency bound for estimating the average treatment effect can be reduced by incorporating both the clinical trial data and external controls. We then derive a doubly robust and locally efficient estimator. The improvement in efficiency is prominent especially when the external control dataset has a large sample size and small variability. Our method allows for a relaxed overlap assumption, and we illustrate with the case where the clinical trial only contains a treated group. We also develop doubly robust and locally efficient approaches that extrapolate the causal effect in the clinical trial to the external population and the overall population. Our results also offer a meaningful implication for trial design and data collection. We evaluate the finite-sample performance of the proposed estimators via simulation. In the Helicobacter pylori infection application, our approach shows that the combination treatment has potential efficacy advantages over the triple therapy.

Factorial designs are widely used due to their ability to accommodate multiple factors simultaneously. The factor-based regression with main effects and some interactions is the dominant strategy for downstream data analysis, delivering point estimators and standard errors via one single regression. Justification of these convenient estimators from the design-based perspective requires quantifying their sampling properties under the assignment mechanism conditioning on the potential outcomes. To this end, we derive the sampling properties of the factor-based regression estimators from both saturated and unsaturated models, and demonstrate the appropriateness of the robust standard errors for the Wald-type inference. We then quantify the bias-variance trade-off between the saturated and unsaturated models from the design-based perspective, and establish a novel design-based Gauss--Markov theorem that ensures the latter's gain in efficiency when the nuisance effects omitted indeed do not exist. As a byproduct of the process, we unify the definitions of factorial effects in various literatures and propose a location-shift strategy for their direct estimation from factor-based regressions. Our theory and simulation suggest using factor-based inference for general factorial effects, preferably with parsimonious specifications in accordance with the prior knowledge of zero nuisance effects.

We consider a situation where the distribution of a random variable is being estimated by the empirical distribution of noisy measurements of that variable. This is common practice in, for example, teacher value-added models and other fixed-effect models for panel data. We use an asymptotic embedding where the noise shrinks with the sample size to calculate the leading bias in the empirical distribution arising from the presence of noise. The leading bias in the empirical quantile function is equally obtained. These calculations are new in the literature, where only results on smooth functionals such as the mean and variance have been derived. We provide both analytical and jackknife corrections that recenter the limit distribution and yield confidence intervals with correct coverage in large samples. Our approach can be connected to corrections for selection bias and shrinkage estimation and is to be contrasted with deconvolution. Simulation results confirm the much-improved sampling behavior of the corrected estimators. An empirical illustration on heterogeneity in deviations from the law of one price is equally provided.

A main difficulty in actuarial claim size modeling is that there is no simple off-the-shelf distribution that simultaneously provides a good distributional model for the main body and the tail of the data. In particular, covariates may have different effects for small and for large claim sizes. To cope with this problem, we introduce a deep composite regression model whose splicing point is given in terms of a quantile of the conditional claim size distribution rather than a constant. To facilitate M-estimation for such models, we introduce and characterize the class of strictly consistent scoring functions for the triplet consisting a quantile, as well as the lower and upper expected shortfall beyond that quantile. In a second step, this elicitability result is applied to fit deep neural network regression models. We demonstrate the applicability of our approach and its superiority over classical approaches on a real accident insurance data set.

We propose three novel consistent specification tests for quantile regression models which generalize former tests in three ways. First, we allow the covariate effects to be quantile-dependent and nonlinear. Second, we allow parameterizing the conditional quantile functions by appropriate basis functions, rather than parametrically. We are hence able to test for functional forms beyond linearity, while retaining the linear effects as special cases. In both cases, the induced class of conditional distribution functions is tested with a Cram\'{e}r-von Mises type test statistic for which we derive the theoretical limit distribution and propose a bootstrap method. Third, to increase the power of the tests, we further suggest a modified test statistic. We highlight the merits of our tests in a detailed MC study and two real data examples. Our first application to conditional income distributions in Germany indicates that there are not only still significant differences between East and West but also across the quantiles of the conditional income distributions, when conditioning on age and year. The second application to data from the Australian national electricity market reveals the importance of using interaction effects for modelling the highly skewed and heavy-tailed distributions of energy prices conditional on day, time of day and demand.

Fitting regression models with many multivariate responses and covariates can be challenging, but such responses and covariates sometimes have tensor-variate structure. We extend the classical multivariate regression model to exploit such structure in two ways: first, we impose four types of low-rank tensor formats on the regression coefficients. Second, we model the errors using the tensor-variate normal distribution that imposes a Kronecker separable format on the covariance matrix. We obtain maximum likelihood estimators via block-relaxation algorithms and derive their computational complexity and asymptotic distributions. Our regression framework enables us to formulate tensor-variate analysis of variance (TANOVA) methodology. This methodology, when applied in a one-way TANOVA layout, enables us to identify cerebral regions significantly associated with the interaction of suicide attempters or non-attemptor ideators and positive-, negative- or death-connoting words in a functional Magnetic Resonance Imaging study. Another application uses three-way TANOVA on the Labeled Faces in the Wild image dataset to distinguish facial characteristics related to ethnic origin, age group and gender. A R package $totr$ implements the methodology.

Dynamic treatment regimes (DTRs) consist of a sequence of decision rules, one per stage of intervention, that finds effective treatments for individual patients according to patient information history. DTRs can be estimated from models which include the interaction between treatment and a small number of covariates which are often chosen a priori. However, with increasingly large and complex data being collected, it is difficult to know which prognostic factors might be relevant in the treatment rule. Therefore, a more data-driven approach of selecting these covariates might improve the estimated decision rules and simplify models to make them easier to interpret. We propose a variable selection method for DTR estimation using penalized dynamic weighted least squares. Our method has the strong heredity property, that is, an interaction term can be included in the model only if the corresponding main terms have also been selected. Through simulations, we show our method has both the double robustness property and the oracle property, and the newly proposed methods compare favorably with other variable selection approaches.

In this paper, we consider the problem of determining the presence of a given signal in a high-dimensional observation with unknown covariance matrix by using an adaptive matched filter. Traditionally such filters are formed from the sample covariance matrix of some given training data, but, as is well-known, the performance of such filters is poor when the number of training data $n$ is not much larger than the data dimension $p$. We thus seek a covariance estimator to replace sample covariance. To account for the fact that $n$ and $p$ may be of comparable size, we adopt the "large-dimensional asymptotic model" in which $n$ and $p$ go to infinity in a fixed ratio. Under this assumption, we identify a covariance estimator that is asymptotically detection-theoretic optimal within a general shrinkage class inspired by C. Stein, and we give consistent estimates for conditional false-alarm and detection rate of the corresponding adaptive matched filter.

This paper investigates the estimation and inference of the average treatment effect (ATE) using deep neural networks (DNNs) in the potential outcomes framework. Under some regularity conditions, the observed response can be formulated as the response of a mean regression problem with both the confounding variables and the treatment indicator as the independent variables. Using such formulation, we investigate two methods for ATE estimation and inference based on the estimated mean regression function via DNN regression using a specific network architecture. We show that both DNN estimates of ATE are consistent with dimension-free consistency rates under some assumptions on the underlying true mean regression model. Our model assumptions accommodate the potentially complicated dependence structure of the observed response on the covariates, including latent factors and nonlinear interactions between the treatment indicator and confounding variables. We also establish the asymptotic normality of our estimators based on the idea of sample splitting, ensuring precise inference and uncertainty quantification. Simulation studies and real data application justify our theoretical findings and support our DNN estimation and inference methods.