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Hidden Markov models (HMMs) are commonly used for disease progression modeling when the true patient health state is not fully known. Since HMMs typically have multiple local optima, incorporating additional patient covariates can improve parameter estimation and predictive performance. To allow for this, we develop hidden Markov recurrent neural networks (HMRNNs), a special case of recurrent neural networks that combine neural networks' flexibility with HMMs' interpretability. The HMRNN can be reduced to a standard HMM, with an identical likelihood function and parameter interpretations, but can also be combined with other predictive neural networks that take patient information as input. The HMRNN estimates all parameters simultaneously via gradient descent. Using a dataset of Alzheimer's disease patients, we demonstrate how the HMRNN can combine an HMM with other predictive neural networks to improve disease forecasting and to offer a novel clinical interpretation compared with a standard HMM trained via expectation-maximization.

We consider the estimation of densities in multiple subpopulations, where the available sample size in each subpopulation greatly varies. This problem occurs in epidemiology, for example, where different diseases may share similar pathogenic mechanism but differ in their prevalence. Without specifying a parametric form, our proposed method pools information from the population and estimate the density in each subpopulation in a data-driven fashion. Drawing from functional data analysis, low-dimensional approximating density families in the form of exponential families are constructed from the principal modes of variation in the log-densities. Subpopulation densities are subsequently fitted in the approximating families based on likelihood principles and shrinkage. The approximating families increase in their flexibility as the number of components increases and can approximate arbitrary infinite-dimensional densities. We also derive convergence results of the density estimates with discrete observations. The proposed methods are shown to be interpretable and efficient in simulation as well as applications to electronic medical record and rainfall data.

In this paper, we propose a new non-monotone conjugate gradient method for solving unconstrained nonlinear optimization problems. We first modify the non-monotone line search method by introducing a new trigonometric function to calculate the non-monotone parameter, which plays an essential role in the algorithm's efficiency. Then, we apply a convex combination of the Barzilai-Borwein method for calculating the value of step size in each iteration. Under some suitable assumptions, we prove that the new algorithm has the global convergence property. The efficiency and effectiveness of the proposed method are determined in practice by applying the algorithm to some standard test problems and non-negative matrix factorization problems.

Despite the increasing interest in constrained multiobjective optimization in recent years, constrained multiobjective optimization problems (CMOPs) are still unsatisfactory understood and characterized. For this reason, the selection of appropriate CMOPs for benchmarking is difficult and lacks a formal background. We address this issue by extending landscape analysis to constrained multiobjective optimization. By employing four exploratory landscape analysis techniques, we propose 29 landscape features (of which 19 are novel) to characterize CMOPs. These landscape features are then used to compare eight frequently used artificial test suites against a recently proposed suite consisting of real-world problems based on physical models. The experimental results reveal that the artificial test problems fail to adequately represent some realistic characteristics, such as strong negative correlation between the objectives and constraints. Moreover, our findings show that all the studied artificial test suites have advantages and limitations, and that no "perfect" suite exists. Benchmark designers can use the obtained results to select or generate appropriate CMOP instances based on the characteristics they want to explore.

This paper seeks to develop a deeper understanding of the fundamental properties of neural text generations models. The study of artifacts that emerge in machine generated text as a result of modeling choices is a nascent research area. Previously, the extent and degree to which these artifacts surface in generated text has not been well studied. In the spirit of better understanding generative text models and their artifacts, we propose the new task of distinguishing which of several variants of a given model generated a piece of text, and we conduct an extensive suite of diagnostic tests to observe whether modeling choices (e.g., sampling methods, top-$k$ probabilities, model architectures, etc.) leave detectable artifacts in the text they generate. Our key finding, which is backed by a rigorous set of experiments, is that such artifacts are present and that different modeling choices can be inferred by observing the generated text alone. This suggests that neural text generators may be more sensitive to various modeling choices than previously thought.

Generative adversarial networks (GANs) have been extensively studied in the past few years. Arguably the revolutionary techniques are in the area of computer vision such as plausible image generation, image to image translation, facial attribute manipulation and similar domains. Despite the significant success achieved in computer vision field, applying GANs over real-world problems still have three main challenges: (1) High quality image generation; (2) Diverse image generation; and (3) Stable training. Considering numerous GAN-related research in the literature, we provide a study on the architecture-variants and loss-variants, which are proposed to handle these three challenges from two perspectives. We propose loss and architecture-variants for classifying most popular GANs, and discuss the potential improvements with focusing on these two aspects. While several reviews for GANs have been presented, there is no work focusing on the review of GAN-variants based on handling challenges mentioned above. In this paper, we review and critically discuss 7 architecture-variant GANs and 9 loss-variant GANs for remedying those three challenges. The objective of this review is to provide an insight on the footprint that current GANs research focuses on the performance improvement. Code related to GAN-variants studied in this work is summarized on //github.com/sheqi/GAN_Review.

In this article, we introduce a new mode for training Generative Adversarial Networks (GANs). Rather than minimizing the distance of evidence distribution $\tilde{p}(x)$ and the generative distribution $q(x)$, we minimize the distance of $\tilde{p}(x_r)q(x_f)$ and $\tilde{p}(x_f)q(x_r)$. This adversarial pattern can be interpreted as a Turing test in GANs. It allows us to use information of real samples during training generator and accelerates the whole training procedure. We even find that just proportionally increasing the size of discriminator and generator, it succeeds on 256x256 resolution without adjusting hyperparameters carefully.

We introduce an effective model to overcome the problem of mode collapse when training Generative Adversarial Networks (GAN). Firstly, we propose a new generator objective that finds it better to tackle mode collapse. And, we apply an independent Autoencoders (AE) to constrain the generator and consider its reconstructed samples as "real" samples to slow down the convergence of discriminator that enables to reduce the gradient vanishing problem and stabilize the model. Secondly, from mappings between latent and data spaces provided by AE, we further regularize AE by the relative distance between the latent and data samples to explicitly prevent the generator falling into mode collapse setting. This idea comes when we find a new way to visualize the mode collapse on MNIST dataset. To the best of our knowledge, our method is the first to propose and apply successfully the relative distance of latent and data samples for stabilizing GAN. Thirdly, our proposed model, namely Generative Adversarial Autoencoder Networks (GAAN), is stable and has suffered from neither gradient vanishing nor mode collapse issues, as empirically demonstrated on synthetic, MNIST, MNIST-1K, CelebA and CIFAR-10 datasets. Experimental results show that our method can approximate well multi-modal distribution and achieve better results than state-of-the-art methods on these benchmark datasets. Our model implementation is published here: //github.com/tntrung/gaan

Recurrent models for sequences have been recently successful at many tasks, especially for language modeling and machine translation. Nevertheless, it remains challenging to extract good representations from these models. For instance, even though language has a clear hierarchical structure going from characters through words to sentences, it is not apparent in current language models. We propose to improve the representation in sequence models by augmenting current approaches with an autoencoder that is forced to compress the sequence through an intermediate discrete latent space. In order to propagate gradients though this discrete representation we introduce an improved semantic hashing technique. We show that this technique performs well on a newly proposed quantitative efficiency measure. We also analyze latent codes produced by the model showing how they correspond to words and phrases. Finally, we present an application of the autoencoder-augmented model to generating diverse translations.

Discrete random structures are important tools in Bayesian nonparametrics and the resulting models have proven effective in density estimation, clustering, topic modeling and prediction, among others. In this paper, we consider nested processes and study the dependence structures they induce. Dependence ranges between homogeneity, corresponding to full exchangeability, and maximum heterogeneity, corresponding to (unconditional) independence across samples. The popular nested Dirichlet process is shown to degenerate to the fully exchangeable case when there are ties across samples at the observed or latent level. To overcome this drawback, inherent to nesting general discrete random measures, we introduce a novel class of latent nested processes. These are obtained by adding common and group-specific completely random measures and, then, normalising to yield dependent random probability measures. We provide results on the partition distributions induced by latent nested processes, and develop an Markov Chain Monte Carlo sampler for Bayesian inferences. A test for distributional homogeneity across groups is obtained as a by product. The results and their inferential implications are showcased on synthetic and real data.