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The flexoelectric effect, coupling polarization and strain gradient as well as strain and electric field gradients, is universal to dielectrics, but, as compared to piezoelectricity, it is more difficult to harness as it requires field gradients and it is a small-scale effect. These drawbacks can be overcome by suitably designing metamaterials made of a non-piezoelectric base material but exhibiting apparent piezoelectricity. We develop a theoretical and computational framework to perform topology optimization of the representative volume element of such metamaterials by accurately modeling the governing equations of flexoelectricity using a Cartesian B-spline method, describing geometry with a level set, and resorting to genetic algorithms for optimization. We consider a multi-objective optimization problem where area fraction competes with four fundamental piezoelectric functionalities (stress/strain sensor/ actuator). We computationally obtain Pareto fronts, and discuss the different geometries depending on the apparent piezoelectric coefficient being optimized. In general, we find competitive estimations of apparent piezoelectricity as compared to reference materials such as quartz and PZT ceramics. This opens the possibility to design devices for sensing, actuation and energy harvesting from a much wider, cheaper and effective class of materials.

Augmented Reality (AR) has emerged as a significant advancement in surgical procedures, offering a solution to the challenges posed by traditional neuronavigation methods. These conventional techniques often necessitate surgeons to split their focus between the surgical site and a separate monitor that displays guiding images. Over the years, many systems have been developed to register and track the hologram at the targeted locations, each employed its own evaluation technique. On the other hand, hologram displacement measurement is not a straightforward task because of various factors such as occlusion, Vengence-Accomodation Conflict, and unstable holograms in space. In this study, we explore and classify different techniques for assessing an AR-assisted neurosurgery system and propose a new technique to systematize the assessment procedure. Moreover, we conduct a deeper investigation to assess surgeon error in the pre- and intra-operative phases of the surgery based on the respective feedback given. We found that although the system can undergo registration and tracking errors, physical feedback can significantly reduce the error caused by hologram displacement. However, the lack of visual feedback on the hologram does not have a significant effect on the user 3D perception.

In prediction settings where data are collected over time, it is often of interest to understand both the importance of variables for predicting the response at each time point and the importance summarized over the time series. Building on recent advances in estimation and inference for variable importance measures, we define summaries of variable importance trajectories. These measures can be estimated and the same approaches for inference can be applied regardless of the choice of the algorithm(s) used to estimate the prediction function. We propose a nonparametric efficient estimation and inference procedure as well as a null hypothesis testing procedure that are valid even when complex machine learning tools are used for prediction. Through simulations, we demonstrate that our proposed procedures have good operating characteristics, and we illustrate their use by investigating the longitudinal importance of risk factors for suicide attempt.

In this paper we propose a definition of the distributional Riemann curvature tensor in dimension $N\geq 2$ if the underlying metric tensor $g$ defined on a triangulation $\mathcal{T}$ possesses only single-valued tangential-tangential components on codimension 1 simplices. We analyze the convergence of the curvature approximation in the $H^{-2}$-norm if a sequence of interpolants $g_h$ of polynomial order $k\geq 0$ of a smooth metric $g$ is given. We show that for dimension $N=2$ convergence rates of order $\mathcal{O}(h^{k+1})$ are obtained. For $N\geq 3$ convergence holds only in the case $k\geq 1$. Numerical examples demonstrate that our theoretical results are sharp. By choosing appropriate test functions we show that the distributional Gauss and scalar curvature in 2D respectively any dimension are obtained. Further, a first definition of the distributional Ricci curvature tensor in arbitrary dimension is derived, for which our analysis is applicable.

We consider the estimation of the cumulative hazard function, and equivalently the distribution function, with censored data under a setup that preserves the privacy of the survival database. This is done through a $\alpha$-locally differentially private mechanism for the failure indicators and by proposing a non-parametric kernel estimator for the cumulative hazard function that remains consistent under the privatization. Under mild conditions, we also prove lowers bounds for the minimax rates of convergence and show that estimator is minimax optimal under a well-chosen bandwidth.

We propose a new method for the construction of layer-adapted meshes for singularly perturbed differential equations (SPDEs), based on mesh partial differential equations (MPDEs) that incorporate \emph{a posteriori} solution information. There are numerous studies on the development of parameter robust numerical methods for SPDEs that depend on the layer-adapted mesh of Bakhvalov. In~\citep{HiMa2021}, a novel MPDE-based approach for constructing a generalisation of these meshes was proposed. Like with most layer-adapted mesh methods, the algorithms in that article depended on detailed derivations of \emph{a priori} bounds on the SPDE's solution and its derivatives. In this work we extend that approach so that it instead uses \emph{a posteriori} computed estimates of the solution. We present detailed algorithms for the efficient implementation of the method, and numerical results for the robust solution of two-parameter reaction-convection-diffusion problems, in one and two dimensions. We also provide full FEniCS code for a one-dimensional example.

Suppose we want to construct some structure on a bounded-degree graph, e.g., an almost maximum matching, and we want to decide about each edge depending only on its constant-radius neighborhood. We examine and compare the strengths of different extensions of these local algorithms. A common extension is to use preprocessing, which means that we can make some calculation about the whole graph, and each local decision can also depend on this calculation. In this paper, we show that preprocessing is needless: if a nearly optimal local algorithm uses preprocessing, then the same can be achieved by a local algorithm without preprocessing, but with a global randomization.

The formulation of Bayesian inverse problems involves choosing prior distributions; choices that seem equally reasonable may lead to significantly different conclusions. We develop a computational approach to better understand the impact of the hyperparameters defining the prior on the posterior statistics of the quantities of interest. Our approach relies on global sensitivity analysis (GSA) of Bayesian inverse problems with respect to the hyperparameters defining the prior. This, however, is a challenging problem--a naive double loop sampling approach would require running a prohibitive number of Markov chain Monte Carlo (MCMC) sampling procedures. The present work takes a foundational step in making such a sensitivity analysis practical through (i) a judicious combination of efficient surrogate models and (ii) a tailored importance sampling method. In particular, we can perform accurate GSA of posterior prediction statistics with respect to prior hyperparameters without having to repeat MCMC runs. We demonstrate the effectiveness of the approach on a simple Bayesian linear inverse problem and a nonlinear inverse problem governed by an epidemiological model.

Describing the equality conditions of the Alexandrov--Fenchel inequality has been a major open problem for decades. We prove that in the case of convex polytopes, this description is not in the polynomial hierarchy unless the polynomial hierarchy collapses to a finite level. This is the first hardness result for the problem, and is a complexity counterpart of the recent result by Shenfeld and van Handel (arXiv:archive/201104059), which gave a geometric characterization of the equality conditions. The proof involves Stanley's order polytopes and employs poset theoretic technology.