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Neural networks are often biased to spuriously correlated features that provide misleading statistical evidence that does not generalize. This raises an interesting question: ``Does an optimal unbiased functional subnetwork exist in a severely biased network? If so, how to extract such subnetwork?" While empirical evidence has been accumulated about the existence of such unbiased subnetworks, these observations are mainly based on the guidance of ground-truth unbiased samples. Thus, it is unexplored how to discover the optimal subnetworks with biased training datasets in practice. To address this, here we first present our theoretical insight that alerts potential limitations of existing algorithms in exploring unbiased subnetworks in the presence of strong spurious correlations. We then further elucidate the importance of bias-conflicting samples on structure learning. Motivated by these observations, we propose a Debiased Contrastive Weight Pruning (DCWP) algorithm, which probes unbiased subnetworks without expensive group annotations. Experimental results demonstrate that our approach significantly outperforms state-of-the-art debiasing methods despite its considerable reduction in the number of parameters.

Simulation speed matters for neuroscientific research: this includes not only how quickly the simulated model time of a large-scale spiking neuronal network progresses, but also how long it takes to instantiate the network model in computer memory. On the hardware side, acceleration via highly parallel GPUs is being increasingly utilized. On the software side, code generation approaches ensure highly optimized code, at the expense of repeated code regeneration and recompilation after modifications to the network model. Aiming for a greater flexibility with respect to iterative model changes, here we propose a new method for creating network connections interactively, dynamically, and directly in GPU memory through a set of commonly used high-level connection rules. We validate the simulation performance with both consumer and data center GPUs on two neuroscientifically relevant models: a cortical microcircuit of about 77,000 leaky-integrate-and-fire neuron models and 300 million static synapses, and a two-population network recurrently connected using a variety of connection rules. With our proposed ad hoc network instantiation, both network construction and simulation times are comparable or shorter than those obtained with other state-of-the-art simulation technologies, while still meeting the flexibility demands of explorative network modeling.

Anticipating audience reaction towards a certain text is integral to several facets of society ranging from politics, research, and commercial industries. Sentiment analysis (SA) is a useful natural language processing (NLP) technique that utilizes lexical/statistical and deep learning methods to determine whether different-sized texts exhibit positive, negative, or neutral emotions. Recurrent networks are widely used in machine-learning communities for problems with sequential data. However, a drawback of models based on Long-Short Term Memory networks and Gated Recurrent Units is the significantly high number of parameters, and thus, such models are computationally expensive. This drawback is even more significant when the available data are limited. Also, such models require significant over-parameterization and regularization to achieve optimal performance. Tensorized models represent a potential solution. In this paper, we classify the sentiment of some social media posts. We compare traditional recurrent models with their tensorized version, and we show that with the tensorized models, we reach comparable performances with respect to the traditional models while using fewer resources for the training.

This paper presents a multi-step procedure to construct the dynamic motion model of an autonomous quadcopter, identify the model parameters, and design a model-based nonlinear trajectory tracking controller. The aim of the proposed method is to speed up the commissioning of a new quadcopter design, i.e., to enable the drone to perform agile maneuvers with high precision in the shortest time possible. After a brief introduction to the theoretical background of the modelling and control design, the steps of the proposed method are presented using the example of a self-developed quadcopter platform. The performance of the method is tested and evaluated by real flight experiments.

Estimating dynamic treatment effects is essential across various disciplines, offering nuanced insights into the time-dependent causal impact of interventions. However, this estimation presents challenges due to the "curse of dimensionality" and time-varying confounding, which can lead to biased estimates. Additionally, correctly specifying the growing number of treatment assignments and outcome models with multiple exposures seems overly complex. Given these challenges, the concept of double robustness, where model misspecification is permitted, is extremely valuable, yet unachieved in practical applications. This paper introduces a new approach by proposing novel, robust estimators for both treatment assignments and outcome models. We present a "sequential model double robust" solution, demonstrating that double robustness over multiple time points can be achieved when each time exposure is doubly robust. This approach improves the robustness and reliability of dynamic treatment effects estimation, addressing a significant gap in this field.

In recent years we have been able to gather large amounts of genomic data at a fast rate, creating situations where the number of variables greatly exceeds the number of observations. In these situations, most models that can handle a moderately high dimension will now become computationally infeasible. Hence, there is a need for a pre-screening of variables to reduce the dimension efficiently and accurately to a more moderate scale. There has been much work to develop such screening procedures for independent outcomes. However, much less work has been done for high-dimensional longitudinal data, in which the observations can no longer be assumed to be independent. In addition, it is of interest to capture possible interactions between the genomic variable and time in many of these longitudinal studies. This calls for the development of new screening procedures for high-dimensional longitudinal data, where the focus is on interactions with time. In this work, we propose a novel conditional screening procedure that ranks variables according to the likelihood value at the maximum likelihood estimates in a semi-marginal linear mixed model, where the genomic variable and its interaction with time are included in the model. This is to our knowledge the first conditional screening approach for clustered data. We prove that this approach enjoys the sure screening property, and assess the finite sample performance of the method through simulations, with a comparison of an already existing screening approach based on generalized estimating equations.

Classic learning theory suggests that proper regularization is the key to good generalization and robustness. In classification, current training schemes only target the complexity of the classifier itself, which can be misleading and ineffective. Instead, we advocate directly measuring the complexity of the decision boundary. Existing literature is limited in this area with few well-established definitions of boundary complexity. As a proof of concept, we start by analyzing ReLU neural networks, whose boundary complexity can be conveniently characterized by the number of affine pieces. With the help of tropical geometry, we develop a novel method that can explicitly count the exact number of boundary pieces, and as a by-product, the exact number of total affine pieces. Numerical experiments are conducted and distinctive properties of our boundary complexity are uncovered. First, the boundary piece count appears largely independent of other measures, e.g., total piece count, and $l_2$ norm of weights, during the training process. Second, the boundary piece count is negatively correlated with robustness, where popular robust training techniques, e.g., adversarial training or random noise injection, are found to reduce the number of boundary pieces.

Associative memories are devices storing information that can be fully retrieved given partial disclosure of it. We examine a toy model of associative memory and the ultimate limitations it is subjected to within the framework of general probabilistic theories (GPTs), which represent the most general class of physical theories satisfying some basic operational axioms. We ask ourselves how large the dimension of a GPT should be so that it can accommodate $2^m$ states with the property that any $N$ of them are perfectly distinguishable. Call $d(N,m)$ the minimal such dimension. Invoking an old result by Danzer and Gr\"unbaum, we prove that $d(2,m)=m+1$, to be compared with $O(2^m)$ when the GPT is required to be either classical or quantum. This yields an example of a task where GPTs outperform both classical and quantum theory exponentially. More generally, we resolve the case of fixed $N$ and asymptotically large $m$, proving that $d(N,m) \leq m^{1+o_N(1)}$ (as $m\to\infty$) for every $N\geq 2$, which yields again an exponential improvement over classical and quantum theories. Finally, we develop a numerical approach to the general problem of finding the largest $N$-wise mutually distinguishable set for a given GPT, which can be seen as an instance of the maximum clique problem on $N$-regular hypergraphs.

We consider the problem of estimating a scalar target parameter in the presence of nuisance parameters. Replacing the unknown nuisance parameter with a nonparametric estimator, e.g.,a machine learning (ML) model, is convenient but has shown to be inefficient due to large biases. Modern methods, such as the targeted minimum loss-based estimation (TMLE) and double machine learning (DML), achieve optimal performance under flexible assumptions by harnessing ML estimates while mitigating the plug-in bias. To avoid a sub-optimal bias-variance trade-off, these methods perform a debiasing step of the plug-in pre-estimate. Existing debiasing methods require the influence function of the target parameter as input. However, deriving the IF requires specialized expertise and thus obstructs the adaptation of these methods by practitioners. We propose a novel way to debias plug-in estimators which (i) is efficient, (ii) does not require the IF to be implemented, (iii) is computationally tractable, and therefore can be readily adapted to new estimation problems and automated without analytic derivations by the user. We build on the TMLE framework and update a plug-in estimate with a regularized likelihood maximization step over a nonparametric model constructed with a reproducing kernel Hilbert space (RKHS), producing an efficient plug-in estimate for any regular target parameter. Our method, thus, offers the efficiency of competing debiasing techniques without sacrificing the utility of the plug-in approach.

Complete reliance on the fitted model in response surface experiments is risky and relaxing this assumption, whether out of necessity or intentionally, requires an experimenter to account for multiple conflicting objectives. This work provides a methodological framework of a compound optimality criterion comprising elementary criteria responsible for: (i) the quality of the confidence region-based inference to be done using the fitted model (DP-/LP-optimality); (ii) improving the ability to test for the lack-of-fit from specified potential model contamination in the form of extra polynomial terms; and (iii) simultaneous minimisation of the variance and bias of the fitted model parameters arising from this misspecification. The latter two components have been newly developed in accordance with the model-independent 'pure error' approach to the error estimation. The compound criteria and design construction were adapted to restricted randomisation frameworks: blocked and multistratum experiments, where the stratum-by-stratum approach was adopted. A point-exchange algorithm was employed for searching for nearly optimal designs. The theoretical work is accompanied by one real and two illustrative examples to explore the relationship patterns among the individual components and characteristics of the optimal designs, demonstrating the attainable compromises across the competing objectives and driving some general practical recommendations.