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Convolutional autoencoders are now at the forefront of image compression research. To improve their entropy coding, encoder output is typically analyzed with a second autoencoder to generate per-variable parametrized prior probability distributions. We instead propose a compression scheme that uses a single convolutional autoencoder and multiple learned prior distributions working as a competition of experts. Trained prior distributions are stored in a static table of cumulative distribution functions. During inference, this table is used by an entropy coder as a look-up-table to determine the best prior for each spatial location. Our method offers rate-distortion performance comparable to that obtained with a predicted parametrized prior with only a fraction of its entropy coding and decoding complexity.

In this study, we develop a novel estimation method for quantile treatment effects (QTE) under rank invariance and rank stationarity assumptions. Ishihara (2020) explores identification of the nonseparable panel data model under these assumptions and proposes a parametric estimation based on the minimum distance method. However, when the dimensionality of the covariates is large, the minimum distance estimation using this process is computationally demanding. To overcome this problem, we propose a two-step estimation method based on the quantile regression and minimum distance methods. We then show the uniform asymptotic properties of our estimator and the validity of the nonparametric bootstrap. The Monte Carlo studies indicate that our estimator performs well in finite samples. Finally, we present two empirical illustrations, to estimate the distributional effects of insurance provision on household production and TV watching on child cognitive development.

High dimensional non-Gaussian time series data are increasingly encountered in a wide range of applications. Conventional estimation methods and technical tools are inadequate when it comes to ultra high dimensional and heavy-tailed data. We investigate robust estimation of high dimensional autoregressive models with fat-tailed innovation vectors by solving a regularized regression problem using convex robust loss function. As a significant improvement, the dimension can be allowed to increase exponentially with the sample size to ensure consistency under very mild moment conditions. To develop the consistency theory, we establish a new Bernstein type inequality for the sum of autoregressive models. Numerical results indicate a good performance of robust estimates.

Modeling and drawing inference on the joint associations between single nucleotide polymorphisms and a disease has sparked interest in genome-wide associations studies. In the motivating Boston Lung Cancer Survival Cohort (BLCSC) data, the presence of a large number of single nucleotide polymorphisms of interest, though smaller than the sample size, challenges inference on their joint associations with the disease outcome. In similar settings, we find that neither the de-biased lasso approach (van de Geer et al. 2014), which assumes sparsity on the inverse information matrix, nor the standard maximum likelihood method can yield confidence intervals with satisfactory coverage probabilities for generalized linear models. Under this "large $n$, diverging $p$" scenario, we propose an alternative de-biased lasso approach by directly inverting the Hessian matrix without imposing the matrix sparsity assumption, which further reduces bias compared to the original de-biased lasso and ensures valid confidence intervals with nominal coverage probabilities. We establish the asymptotic distributions of any linear combinations of the parameter estimates, which lays the theoretical ground for drawing inference. Simulations show that the proposed refined de-biased estimating method performs well in removing bias and yields honest confidence interval coverage. We use the proposed method to analyze the aforementioned BLCSC data, a large scale hospital-based epidemiology cohort study, that investigates the joint effects of genetic variants on lung cancer risks.

There has been a rich development of vector autoregressive (VAR) models for modeling temporally correlated multivariate outcomes. However, the existing VAR literature has largely focused on single subject parametric analysis, with some recent extensions to multi-subject modeling with known subgroups. Motivated by the need for flexible Bayesian methods that can pool information across heterogeneous samples in an unsupervised manner, we develop a novel class of non-parametric Bayesian VAR models based on heterogeneous multi-subject data. In particular, we propose a product of Dirichlet process mixture priors that enables separate clustering at multiple scales, which result in partially overlapping clusters that provide greater flexibility. We develop several variants of the method to cater to varying levels of heterogeneity. We implement an efficient posterior computation scheme and illustrate posterior consistency properties under reasonable assumptions on the true density. Extensive numerical studies show distinct advantages over competing methods in terms of estimating model parameters and identifying the true clustering and sparsity structures. Our analysis of resting state fMRI data from the Human Connectome Project reveals biologically interpretable differences between distinct fluid intelligence groups, and reproducible parameter estimates. In contrast, single-subject VAR analyses followed by permutation testing result in negligible differences, which is biologically implausible.

Many functions of interest are in a high-dimensional space but exhibit low-dimensional structures. This paper studies regression of a $s$-H\"{o}lder function $f$ in $\mathbb{R}^D$ which varies along a central subspace of dimension $d$ while $d\ll D$. A direct approximation of $f$ in $\mathbb{R}^D$ with an $\varepsilon$ accuracy requires the number of samples $n$ in the order of $\varepsilon^{-(2s+D)/s}$. In this paper, we analyze the Generalized Contour Regression (GCR) algorithm for the estimation of the central subspace and use piecewise polynomials for function approximation. GCR is among the best estimators for the central subspace, but its sample complexity is an open question. We prove that GCR leads to a mean squared estimation error of $O(n^{-1})$ for the central subspace, if a variance quantity is exactly known. The estimation error of this variance quantity is also given in this paper. The mean squared regression error of $f$ is proved to be in the order of $\left(n/\log n\right)^{-\frac{2s}{2s+d}}$ where the exponent depends on the dimension of the central subspace $d$ instead of the ambient space $D$. This result demonstrates that GCR is effective in learning the low-dimensional central subspace. We also propose a modified GCR with improved efficiency. The convergence rate is validated through several numerical experiments.

In the statistical literature, sparse modeling is the standard approach to achieve improvements in prediction tasks and interpretability. Alternatively, in the seminal paper "Statistical Modeling: The Two Cultures," Breiman (2001) advocated for the adoption of algorithmic approaches to generate ensembles to achieve superior prediction accuracy than single-model methods at the cost of loss of interpretability. In a recent important and critical paper, Rudin (2019) argued that blackbox algorithmic approaches should be avoided for high-stakes decisions and that the tradeoff between accuracy and interpretability is a myth. In response to this recent change in philosophy, we generalize best subset selection (BSS) to best split selection (BSpS), a data-driven approach aimed at finding the optimal split of predictor variables among the models of an ensemble. The proposed methodology results in an ensemble of sparse and diverse models that provide possible mechanisms that explain the relationship between the predictors and the response. The high computational cost of BSpS motivates the need for computational tractable ways to approximate the exhaustive search, and we benchmark one such recent proposal by Christidis et al. (2020) based on a multi-convex relaxation. Our objective with this article is to motivate research in this new exciting field with great potential for data analysis tasks for high-dimensional data.

The asymptotic behaviour of Linear Spectral Statistics (LSS) of the smoothed periodogram estimator of the spectral coherency matrix of a complex Gaussian high-dimensional time series $(\y_n)_{n \in \mathbb{Z}}$ with independent components is studied under the asymptotic regime where the sample size $N$ converges towards $+\infty$ while the dimension $M$ of $\y$ and the smoothing span of the estimator grow to infinity at the same rate in such a way that $\frac{M}{N} \rightarrow 0$. It is established that, at each frequency, the estimated spectral coherency matrix is close from the sample covariance matrix of an independent identically $\mathcal{N}_{\mathbb{C}}(0,\I_M)$ distributed sequence, and that its empirical eigenvalue distribution converges towards the Marcenko-Pastur distribution. This allows to conclude that each LSS has a deterministic behaviour that can be evaluated explicitly. Using concentration inequalities, it is shown that the order of magnitude of the supremum over the frequencies of the deviation of each LSS from its deterministic approximation is of the order of $\frac{1}{M} + \frac{\sqrt{M}}{N}+ (\frac{M}{N})^{3}$ where $N$ is the sample size. Numerical simulations supports our results.

This PhD thesis contains several contributions to the field of statistical causal modeling. Statistical causal models are statistical models embedded with causal assumptions that allow for the inference and reasoning about the behavior of stochastic systems affected by external manipulation (interventions). This thesis contributes to the research areas concerning the estimation of causal effects, causal structure learning, and distributionally robust (out-of-distribution generalizing) prediction methods. We present novel and consistent linear and non-linear causal effects estimators in instrumental variable settings that employ data-dependent mean squared prediction error regularization. Our proposed estimators show, in certain settings, mean squared error improvements compared to both canonical and state-of-the-art estimators. We show that recent research on distributionally robust prediction methods has connections to well-studied estimators from econometrics. This connection leads us to prove that general K-class estimators possess distributional robustness properties. We, furthermore, propose a general framework for distributional robustness with respect to intervention-induced distributions. In this framework, we derive sufficient conditions for the identifiability of distributionally robust prediction methods and present impossibility results that show the necessity of several of these conditions. We present a new structure learning method applicable in additive noise models with directed trees as causal graphs. We prove consistency in a vanishing identifiability setup and provide a method for testing substructure hypotheses with asymptotic family-wise error control that remains valid post-selection. Finally, we present heuristic ideas for learning summary graphs of nonlinear time-series models.

Recently, the retrieval models based on dense representations have been gradually applied in the first stage of the document retrieval tasks, showing better performance than traditional sparse vector space models. To obtain high efficiency, the basic structure of these models is Bi-encoder in most cases. However, this simple structure may cause serious information loss during the encoding of documents since the queries are agnostic. To address this problem, we design a method to mimic the queries on each of the documents by an iterative clustering process and represent the documents by multiple pseudo queries (i.e., the cluster centroids). To boost the retrieval process using approximate nearest neighbor search library, we also optimize the matching function with a two-step score calculation procedure. Experimental results on several popular ranking and QA datasets show that our model can achieve state-of-the-art results.