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Wrinkle defects were found widely exist in the field of industrial products, i.e. wind turbine blades and filament-wound composite pressure vessels. The magnitude of wrinkle wavelength varies from several millimeters to over one hundred millimeters. Locating the wrinkle defects and measuring their responses are very important to the assessment of the structures that containing wrinkle defects. A meso-mechanical modeling is presented based on the homogenization method to obtain the effective stiffness of a graded wrinkle. The finite element simulation predicts the trans-scale response of out-of-plane displacement of wrinkled laminates, where the maximum displacement ranges from nanoscale to millimeter scale. Such trans-scale effect requires different measurement approaches to observe the displacement responses. Here we employed Shearography (Speckle Pattern Shearing Interferometry) and fringe projection profilometry (FPP) method respectively according to the different magnitude of displacement. In FPP method, a displacement extraction algorithm was presented to obtain the out-of-plane displacement. The measurement sensitivity and accuracy of Shearography and FPP are compared, which provides a quantitative reference for industrial non-destructive test.

A new model is presented to predict hydrogen-assisted fatigue. The model combines a phase field description of fracture and fatigue, stress-assisted hydrogen diffusion, and a toughness degradation formulation with cyclic and hydrogen contributions. Hydrogen-assisted fatigue crack growth predictions exhibit an excellent agreement with experiments over all the scenarios considered, spanning multiple load ratios, H2 pressures and loading frequencies. These are obtained without any calibration with hydrogen-assisted fatigue data, taking as input only mechanical and hydrogen transport material properties, the material's fatigue characteristics (from a single test in air), and the sensitivity of fracture toughness to hydrogen content. Furthermore, the model is used to determine: (i) what are suitable test loading frequencies to obtain conservative data, and (ii) the underestimation made when not pre-charging samples. The model can handle both laboratory specimens and large-scale engineering components, enabling the Virtual Testing paradigm in infrastructure exposed to hydrogen environments and cyclic loading.

We study the use of local consistency methods as reductions between constraint satisfaction problems (CSPs), and promise version thereof, with the aim to classify these reductions in a similar way as the algebraic approach classifies gadget reductions between CSPs. This research is motivated by the requirement of more expressive reductions in the scope of promise CSPs. While gadget reductions are enough to provide all necessary hardness in the scope of (finite domain) non-promise CSP, in promise CSPs a wider class of reductions needs to be used. We provide a general framework of reductions, which we call consistency reductions, that covers most (if not all) reductions recently used for proving NP-hardness of promise CSPs. We prove some basic properties of these reductions, and provide the first steps towards understanding the power of consistency reductions by characterizing a fragment associated to arc-consistency in terms of polymorphisms of the template. In addition to showing hardness, consistency reductions can also be used to provide feasible algorithms by reducing to a fixed tractable (promise) CSP, for example, to solving systems of affine equations. In this direction, among other results, we describe the well-known Sherali-Adams hierarchy for CSP in terms of a consistency reduction to linear programming.

Large deformation analysis in geomechanics plays an important role in understanding the nature of post-failure flows and hazards associated with landslides under different natural calamities. In this study, a SPH framework is proposed for large deformation and failure analysis of geomaterials. An adaptive B-spline kernel function in combination with a pressure zone approach is proposed to counteract the numerical issues associated with tensile instability. The proposed algorithm is validated using a soil cylinder drop problem, and the results are compared with FEM. Finally, the effectiveness of the proposed algorithm in the successful removal of tensile instability and stress noise is demonstrated using the well-studied slope failure simulation of a cohesive soil vertical cut.

Deep learning has enabled breakthroughs in automated diagnosis from medical imaging, with many successful applications in ophthalmology. However, standard medical image classification approaches only assess disease presence at the time of acquisition, neglecting the common clinical setting of longitudinal imaging. For slow, progressive eye diseases like age-related macular degeneration (AMD) and primary open-angle glaucoma (POAG), patients undergo repeated imaging over time to track disease progression and forecasting the future risk of developing disease is critical to properly plan treatment. Our proposed Longitudinal Transformer for Survival Analysis (LTSA) enables dynamic disease prognosis from longitudinal medical imaging, modeling the time to disease from sequences of fundus photography images captured over long, irregular time periods. Using longitudinal imaging data from the Age-Related Eye Disease Study (AREDS) and Ocular Hypertension Treatment Study (OHTS), LTSA significantly outperformed a single-image baseline in 19/20 head-to-head comparisons on late AMD prognosis and 18/20 comparisons on POAG prognosis. A temporal attention analysis also suggested that, while the most recent image is typically the most influential, prior imaging still provides additional prognostic value.

This paper addresses the problem of pathological lung segmentation, a significant challenge in medical image analysis, particularly pronounced in cases of peripheral opacities (severe fibrosis and consolidation) because of the textural similarity between lung tissue and surrounding areas. To overcome these challenges, this paper emphasizes the use of CycleGAN for unpaired image-to-image translation, in order to provide an augmentation method able to generate fake pathological images matching an existing ground truth. Although previous studies have employed CycleGAN, they often neglect the challenge of shape deformation, which is crucial for accurate medical image segmentation. Our work introduces an innovative strategy that incorporates additional loss functions. Specifically, it proposes an L1 loss based on the lung surrounding which shape is constrained to remain unchanged at the transition from the healthy to pathological domains. The lung surrounding is derived based on ground truth lung masks available in the healthy domain. Furthermore, preprocessing steps, such as cropping based on ribs/vertebra locations, are applied to refine the input for the CycleGAN, ensuring that the network focus on the lung region. This is essential to avoid extraneous biases, such as the zoom effect bias, which can divert attention from the main task. The method is applied to enhance in semi-supervised manner the lung segmentation process by employing a U-Net model trained with on-the-fly data augmentation incorporating synthetic pathological tissues generated by the CycleGAN model. Preliminary results from this research demonstrate significant qualitative and quantitative improvements, setting a new benchmark in the field of pathological lung segmentation. Our code is available at //github.com/noureddinekhiati/Semi-supervised-lung-segmentation

This tutorial discusses methodology for causal inference using longitudinal modified treatment policies. This method facilitates the mathematical formalization, identification, and estimation of many novel parameters, and mathematically generalizes many commonly used parameters, such as the average treatment effect. Longitudinal modified treatment policies apply to a wide variety of exposures, including binary, multivariate, and continuous, and can accommodate time-varying treatments and confounders, competing risks, loss-to-follow-up, as well as survival, binary, or continuous outcomes. Longitudinal modified treatment policies can be seen as an extension of static and dynamic interventions to involve the natural value of treatment, and, like dynamic interventions, can be used to define alternative estimands with a positivity assumption that is more likely to be satisfied than estimands corresponding to static interventions. This tutorial aims to illustrate several practical uses of the longitudinal modified treatment policy methodology, including describing different estimation strategies and their corresponding advantages and disadvantages. We provide numerous examples of types of research questions which can be answered using longitudinal modified treatment policies. We go into more depth with one of these examples--specifically, estimating the effect of delaying intubation on critically ill COVID-19 patients' mortality. We demonstrate the use of the open-source R package lmtp to estimate the effects, and we provide code on //github.com/kathoffman/lmtp-tutorial.

Diagnosing and managing a patient is a complex, sequential decision making process that requires physicians to obtain information -- such as which tests to perform -- and to act upon it. Recent advances in artificial intelligence (AI) and large language models (LLMs) promise to profoundly impact clinical care. However, current evaluation schemes overrely on static medical question-answering benchmarks, falling short on interactive decision-making that is required in real-life clinical work. Here, we present AgentClinic: a multimodal benchmark to evaluate LLMs in their ability to operate as agents in simulated clinical environments. In our benchmark, the doctor agent must uncover the patient's diagnosis through dialogue and active data collection. We present two open benchmarks: a multimodal image and dialogue environment, AgentClinic-NEJM, and a dialogue-only environment, AgentClinic-MedQA. We embed cognitive and implicit biases both in patient and doctor agents to emulate realistic interactions between biased agents. We find that introducing bias leads to large reductions in diagnostic accuracy of the doctor agents, as well as reduced compliance, confidence, and follow-up consultation willingness in patient agents. Evaluating a suite of state-of-the-art LLMs, we find that several models that excel in benchmarks like MedQA are performing poorly in AgentClinic-MedQA. We find that the LLM used in the patient agent is an important factor for performance in the AgentClinic benchmark. We show that both having limited interactions as well as too many interaction reduces diagnostic accuracy in doctor agents. The code and data for this work is publicly available at //AgentClinic.github.io.

The study of associations between an individual's age and imaging and non-imaging data is an active research area that attempts to aid understanding of the effects and patterns of aging. In this work we have conducted a supervoxel-wise association study between both volumetric and tissue density features in coronary computed tomography angiograms and the chronological age of a subject, to understand the localized changes in morphology and tissue density with age. To enable a supervoxel-wise study of volume and tissue density, we developed a novel method based on image segmentation, inter-subject image registration, and robust supervoxel-based correlation analysis, to achieve a statistical association study between the images and age. We evaluate the registration methodology in terms of the Dice coefficient for the heart chambers and myocardium, and the inverse consistency of the transformations, showing that the method works well in most cases with high overlap and inverse consistency. In a sex-stratified study conducted on a subset of $n=1388$ images from the SCAPIS study, the supervoxel-wise analysis was able to find localized associations with age outside of the commonly segmented and analyzed sub-regions, and several substantial differences between the sexes in association of age and volume.

We present and analyze three distinct semi-discrete schemes for solving nonlocal geometric flows incorporating perimeter terms. These schemes are based on the finite difference method, the finite element method, and the finite element method with a specific tangential motion. We offer rigorous proofs of quadratic convergence under $H^1$-norm for the first scheme and linear convergence under $H^1$-norm for the latter two schemes. All error estimates rely on the observation that the error of the nonlocal term can be controlled by the error of the local term. Furthermore, we explore the relationship between the convergence under $L^\infty$-norm and manifold distance. Extensive numerical experiments are conducted to verify the convergence analysis, and demonstrate the accuracy of our schemes under various norms for different types of nonlocal flows.