Using observational data to learn causal relationships is essential when randomized experiments are not possible, such as in healthcare. Discovering causal relationships in time-series health data is even more challenging when relationships change over the course of a disease, such as medications that are most effective early on or for individuals with severe disease. Stage variables such as weeks of pregnancy, disease stages, or biomarkers like HbA1c, can influence what causal relationships are true for a patient. However, causal inference within each stage is often not possible due to limited amounts of data, and combining all data risks incorrect or missed inferences. To address this, we propose Causal Discovery with Stage Variables (CDSV), which uses stage variables to reweight data from multiple time-series while accounting for different causal relationships in each stage. In simulated data, CDSV discovers more causes with fewer false discoveries compared to baselines, in eICU it has a lower FDR than baselines, and in MIMIC-III it discovers more clinically relevant causes of high blood pressure.
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Algorithms for causal discovery have recently undergone rapid advances and increasingly draw on flexible nonparametric methods to process complex data. With these advances comes a need for adequate empirical validation of the causal relationships learned by different algorithms. However, for most real data sources true causal relations remain unknown. This issue is further compounded by privacy concerns surrounding the release of suitable high-quality data. To help address these challenges, we gather a complex dataset comprising measurements from an assembly line in a manufacturing context. This line consists of numerous physical processes for which we are able to provide ground truth causal relationships on the basis of a detailed study of the underlying physics. We use the assembly line data and associated ground truth information to build a system for generation of semisynthetic manufacturing data that supports benchmarking of causal discovery methods. To accomplish this, we employ distributional random forests in order to flexibly estimate and represent conditional distributions that may be combined into joint distributions that strictly adhere to a causal model over the observed variables. The estimated conditionals and tools for data generation are made available in our Python library $\texttt{causalAssembly}$. Using the library, we showcase how to benchmark several well-known causal discovery algorithms.
We present new results on average causal effects in settings with unmeasured exposure-outcome confounding. Our results are motivated by a class of estimands, e.g., frequently of interest in medicine and public health, that are currently not targeted by standard approaches for average causal effects. We recognize these estimands as queries about the average causal effect of an intervening variable. We anchor our introduction of these estimands in an investigation of the role of chronic pain and opioid prescription patterns in the opioid epidemic, and illustrate how conventional approaches will lead unreplicable estimates with ambiguous policy implications. We argue that our altenative effects are replicable and have clear policy implications, and furthermore are non-parametrically identified by the classical frontdoor formula. As an independent contribution, we derive a new semiparametric efficient estimator of the frontdoor formula with a uniform sample boundedness guarantee. This property is unique among previously-described estimators in its class, and we demonstrate superior performance in finite-sample settings. Theoretical results are applied with data from the National Health and Nutrition Examination Survey.
Supervised machine learning (ML) and deep learning (DL) algorithms excel at predictive tasks, but it is commonly assumed that they often do so by exploiting non-causal correlations, which may limit both interpretability and generalizability. Here, we show that this trade-off between explanation and prediction is not as deep and fundamental as expected. Whereas ML and DL algorithms will indeed tend to use non-causal features for prediction when fed indiscriminately with all data, it is possible to constrain the learning process of any ML and DL algorithm by selecting features according to Pearl's backdoor adjustment criterion. In such a situation, some algorithms, in particular deep neural networks, can provide near unbiased effect estimates under feature collinearity. Remaining biases are explained by the specific algorithmic structures as well as hyperparameter choice. Consequently, optimal hyperparameter settings are different when tuned for prediction or inference, confirming the general expectation of a trade-off between prediction and explanation. However, the effect of this trade-off is small compared to the effect of a causally constrained feature selection. Thus, once the causal relationship between the features is accounted for, the difference between prediction and explanation may be much smaller than commonly assumed. We also show that such causally constrained models generalize better to new data with altered collinearity structures, suggesting generalization failure may often be due to a lack of causal learning. Our results not only provide a perspective for using ML for inference of (causal) effects but also help to improve the generalizability of fitted ML and DL models to new data.
In recent years, online social networks have been the target of adversaries who seek to introduce discord into societies, to undermine democracies and to destabilize communities. Often the goal is not to favor a certain side of a conflict but to increase disagreement and polarization. To get a mathematical understanding of such attacks, researchers use opinion-formation models from sociology, such as the Friedkin--Johnsen model, and formally study how much discord the adversary can produce when altering the opinions for only a small set of users. In this line of work, it is commonly assumed that the adversary has full knowledge about the network topology and the opinions of all users. However, the latter assumption is often unrealistic in practice, where user opinions are not available or simply difficult to estimate accurately. To address this concern, we raise the following question: Can an attacker sow discord in a social network, even when only the network topology is known? We answer this question affirmatively. We present approximation algorithms for detecting a small set of users who are highly influential for the disagreement and polarization in the network. We show that when the adversary radicalizes these users and if the initial disagreement/polarization in the network is not very high, then our method gives a constant-factor approximation on the setting when the user opinions are known. To find the set of influential users, we provide a novel approximation algorithm for a variant of MaxCut in graphs with positive and negative edge weights. We experimentally evaluate our methods, which have access only to the network topology, and we find that they have similar performance as methods that have access to the network topology and all user opinions. We further present an NP-hardness proof, which was an open question by Chen and Racz [IEEE Trans. Netw. Sci. Eng., 2021].
Multivariate sequential data collected in practice often exhibit temporal irregularities, including nonuniform time intervals and component misalignment. However, if uneven spacing and asynchrony are endogenous characteristics of the data rather than a result of insufficient observation, the information content of these irregularities plays a defining role in characterizing the multivariate dependence structure. Existing approaches for probabilistic forecasting either overlook the resulting statistical heterogeneities, are susceptible to imputation biases, or impose parametric assumptions on the data distribution. This paper proposes an end-to-end solution that overcomes these limitations by allowing the observation arrival times to play the central role of model construction, which is at the core of temporal irregularities. To acknowledge temporal irregularities, we first enable unique hidden states for components so that the arrival times can dictate when, how, and which hidden states to update. We then develop a conditional flow representation to non-parametrically represent the data distribution, which is typically non-Gaussian, and supervise this representation by carefully factorizing the log-likelihood objective to select conditional information that facilitates capturing time variation and path dependency. The broad applicability and superiority of the proposed solution are confirmed by comparing it with existing approaches through ablation studies and testing on real-world datasets.
We study a constructive algorithm that approximates Gateaux derivatives for statistical functionals by finite differencing, with a focus on functionals that arise in causal inference. We study the case where probability distributions are not known a priori but need to be estimated from data. These estimated distributions lead to empirical Gateaux derivatives, and we study the relationships between empirical, numerical, and analytical Gateaux derivatives. Starting with a case study of the interventional mean (average potential outcome), we delineate the relationship between finite differences and the analytical Gateaux derivative. We then derive requirements on the rates of numerical approximation in perturbation and smoothing that preserve the statistical benefits of one-step adjustments, such as rate double robustness. We then study more complicated functionals such as dynamic treatment regimes, the linear-programming formulation for policy optimization in infinite-horizon Markov decision processes, and sensitivity analysis in causal inference. More broadly, we study optimization-based estimators, since this begets a class of estimands where identification via regression adjustment is straightforward but obtaining influence functions under minor variations thereof is not. The ability to approximate bias adjustments in the presence of arbitrary constraints illustrates the usefulness of constructive approaches for Gateaux derivatives. We also find that the statistical structure of the functional (rate double robustness) can permit less conservative rates for finite-difference approximation. This property, however, can be specific to particular functionals; e.g., it occurs for the average potential outcome (hence average treatment effect) but not the infinite-horizon MDP policy value.
Analyzing observational data from multiple sources can be useful for increasing statistical power to detect a treatment effect; however, practical constraints such as privacy considerations may restrict individual-level information sharing across data sets. This paper develops federated methods that only utilize summary-level information from heterogeneous data sets. Our federated methods provide doubly-robust point estimates of treatment effects as well as variance estimates. We derive the asymptotic distributions of our federated estimators, which are shown to be asymptotically equivalent to the corresponding estimators from the combined, individual-level data. We show that to achieve these properties, federated methods should be adjusted based on conditions such as whether models are correctly specified and stable across heterogeneous data sets.
We present a large-scale study on unsupervised spatiotemporal representation learning from videos. With a unified perspective on four recent image-based frameworks, we study a simple objective that can easily generalize all these methods to space-time. Our objective encourages temporally-persistent features in the same video, and in spite of its simplicity, it works surprisingly well across: (i) different unsupervised frameworks, (ii) pre-training datasets, (iii) downstream datasets, and (iv) backbone architectures. We draw a series of intriguing observations from this study, e.g., we discover that encouraging long-spanned persistency can be effective even if the timespan is 60 seconds. In addition to state-of-the-art results in multiple benchmarks, we report a few promising cases in which unsupervised pre-training can outperform its supervised counterpart. Code is made available at //github.com/facebookresearch/SlowFast
This paper focuses on the expected difference in borrower's repayment when there is a change in the lender's credit decisions. Classical estimators overlook the confounding effects and hence the estimation error can be magnificent. As such, we propose another approach to construct the estimators such that the error can be greatly reduced. The proposed estimators are shown to be unbiased, consistent, and robust through a combination of theoretical analysis and numerical testing. Moreover, we compare the power of estimating the causal quantities between the classical estimators and the proposed estimators. The comparison is tested across a wide range of models, including linear regression models, tree-based models, and neural network-based models, under different simulated datasets that exhibit different levels of causality, different degrees of nonlinearity, and different distributional properties. Most importantly, we apply our approaches to a large observational dataset provided by a global technology firm that operates in both the e-commerce and the lending business. We find that the relative reduction of estimation error is strikingly substantial if the causal effects are accounted for correctly.
Multivariate time series forecasting is extensively studied throughout the years with ubiquitous applications in areas such as finance, traffic, environment, etc. Still, concerns have been raised on traditional methods for incapable of modeling complex patterns or dependencies lying in real word data. To address such concerns, various deep learning models, mainly Recurrent Neural Network (RNN) based methods, are proposed. Nevertheless, capturing extremely long-term patterns while effectively incorporating information from other variables remains a challenge for time-series forecasting. Furthermore, lack-of-explainability remains one serious drawback for deep neural network models. Inspired by Memory Network proposed for solving the question-answering task, we propose a deep learning based model named Memory Time-series network (MTNet) for time series forecasting. MTNet consists of a large memory component, three separate encoders, and an autoregressive component to train jointly. Additionally, the attention mechanism designed enable MTNet to be highly interpretable. We can easily tell which part of the historic data is referenced the most.
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