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Accurate detection and segmentation of brain tumors is critical for medical diagnosis. However, current supervised learning methods require extensively annotated images and the state-of-the-art generative models used in unsupervised methods often have limitations in covering the whole data distribution. In this paper, we propose a novel framework Two-Stage Generative Model (TSGM) that combines Cycle Generative Adversarial Network (CycleGAN) and Variance Exploding stochastic differential equation using joint probability (VE-JP) to improve brain tumor detection and segmentation. The CycleGAN is trained on unpaired data to generate abnormal images from healthy images as data prior. Then VE-JP is implemented to reconstruct healthy images using synthetic paired abnormal images as a guide, which alters only pathological regions but not regions of healthy. Notably, our method directly learned the joint probability distribution for conditional generation. The residual between input and reconstructed images suggests the abnormalities and a thresholding method is subsequently applied to obtain segmentation results. Furthermore, the multimodal results are weighted with different weights to improve the segmentation accuracy further. We validated our method on three datasets, and compared with other unsupervised methods for anomaly detection and segmentation. The DSC score of 0.8590 in BraTs2020 dataset, 0.6226 in ITCS dataset and 0.7403 in In-house dataset show that our method achieves better segmentation performance and has better generalization.

There is a growing interest in model-based deep learning (MBDL) for solving imaging inverse problems. MBDL networks can be seen as iterative algorithms that estimate the desired image using a physical measurement model and a learned image prior specified using a convolutional neural net (CNNs). The iterative nature of MBDL networks increases the test-time computational complexity, which limits their applicability in certain large-scale applications. We address this issue by presenting structured pruning algorithm for model-based deep learning (SPADE) as the first structured pruning algorithm for MBDL networks. SPADE reduces the computational complexity of CNNs used within MBDL networks by pruning its non-essential weights. We propose three distinct strategies to fine-tune the pruned MBDL networks to minimize the performance loss. Each fine-tuning strategy has a unique benefit that depends on the presence of a pre-trained model and a high-quality ground truth. We validate SPADE on two distinct inverse problems, namely compressed sensing MRI and image super-resolution. Our results highlight that MBDL models pruned by SPADE can achieve substantial speed up in testing time while maintaining competitive performance.

The escalating risk of collisions and the accumulation of space debris in Low Earth Orbit (LEO) has reached critical concern due to the ever increasing number of spacecraft. Addressing this crisis, especially in dealing with non-cooperative and unidentified space debris, is of paramount importance. This paper contributes to efforts in enabling autonomous swarms of small chaser satellites for target geometry determination and safe flight trajectory planning for proximity operations in LEO. Our research explores on-orbit use of the You Only Look Once v5 (YOLOv5) object detection model trained to detect satellite components. While this model has shown promise, its inherent lack of interpretability hinders human understanding, a critical aspect of validating algorithms for use in safety-critical missions. To analyze the decision processes, we introduce Probabilistic Explanations for Entropic Knowledge extraction (PEEK), a method that utilizes information theoretic analysis of the latent representations within the hidden layers of the model. Through both synthetic in hardware-in-the-loop experiments, PEEK illuminates the decision-making processes of the model, helping identify its strengths, limitations and biases.

Submodular maximization under various constraints is a fundamental problem studied continuously, in both computer science and operations research, since the late $1970$'s. A central technique in this field is to approximately optimize the multilinear extension of the submodular objective, and then round the solution. The use of this technique requires a solver able to approximately maximize multilinear extensions. Following a long line of work, Buchbinder and Feldman (2019) described such a solver guaranteeing $0.385$-approximation for down-closed constraints, while Oveis Gharan and Vondr\'ak (2011) showed that no solver can guarantee better than $0.478$-approximation. In this paper, we present a solver guaranteeing $0.401$-approximation, which significantly reduces the gap between the best known solver and the inapproximability result. The design and analysis of our solver are based on a novel bound that we prove for DR-submodular functions. This bound improves over a previous bound due to Feldman et al. (2011) that is used by essentially all state-of-the-art results for constrained maximization of general submodular/DR-submodular functions. Hence, we believe that our new bound is likely to find many additional applications in related problems, and to be a key component for further improvement.

Approximate Bayesian Computation (ABC) has gained popularity as a method for conducting inference and forecasting in complex models, most notably those which are intractable in some sense. In this paper we use ABC to produce probabilistic forecasts in state space models (SSMs). Whilst ABC-based forecasting in correctly-specified SSMs has been studied, the misspecified case has not been investigated, and it is that case which we emphasize. We invoke recent principles of 'focused' Bayesian prediction, whereby Bayesian updates are driven by a scoring rule that rewards predictive accuracy; the aim being to produce predictives that perform well in that rule, despite misspecification. Two methods are investigated for producing the focused predictions. In a simulation setting, 'coherent' predictions are in evidence for both methods: the predictive constructed via the use of a particular scoring rule predicts best according to that rule. Importantly, both focused methods typically produce more accurate forecasts than an exact, but misspecified, predictive. An empirical application to a truly intractable SSM completes the paper.

Automatic differentiation (AD) is a critical step in physics-informed machine learning, required for computing the high-order derivatives of network output w.r.t. coordinates. In this paper, we present a novel and lightweight algorithm to conduct such AD for physics-informed operator learning, as we call the trick of Zero Coordinate Shift (ZCS). Instead of making all sampled coordinates leaf variables, ZCS introduces only one scalar-valued leaf variable for each spatial or temporal dimension, leading to a game-changing performance leap by simplifying the wanted derivatives from "many-roots-many-leaves" to "one-root-many-leaves". ZCS is easy to implement with current deep learning libraries; our own implementation is by extending the DeepXDE package. We carry out a comprehensive benchmark analysis and several case studies, training physics-informed DeepONets to solve partial differential equations (PDEs) without data. The results show that ZCS has persistently brought down GPU memory consumption and wall time for training by an order of magnitude, with the savings increasing with problem scale (i.e., number of functions, number of points and order of PDE). As a low-level optimisation, ZCS entails no restrictions on data, physics (PDEs) or network architecture and does not compromise training results from any aspect.

High-fidelity simulators that connect theoretical models with observations are indispensable tools in many sciences. When coupled with machine learning, a simulator makes it possible to infer the parameters of a theoretical model directly from real and simulated observations without explicit use of the likelihood function. This is of particular interest when the latter is intractable. In this work, we introduce a simple extension of the recently proposed likelihood-free frequentist inference (LF2I) approach that has some computational advantages. Like LF2I, this extension yields provably valid confidence sets in parameter inference problems in which a high-fidelity simulator is available. The utility of our algorithm is illustrated by applying it to three pedagogically interesting examples: the first is from cosmology, the second from high-energy physics and astronomy, both with tractable likelihoods, while the third, with an intractable likelihood, is from epidemiology.

Multiple instance learning (MIL) is a powerful tool to solve the weakly supervised classification in whole slide image (WSI) based pathology diagnosis. However, the current MIL methods are usually based on independent and identical distribution hypothesis, thus neglect the correlation among different instances. To address this problem, we proposed a new framework, called correlated MIL, and provided a proof for convergence. Based on this framework, we devised a Transformer based MIL (TransMIL), which explored both morphological and spatial information. The proposed TransMIL can effectively deal with unbalanced/balanced and binary/multiple classification with great visualization and interpretability. We conducted various experiments for three different computational pathology problems and achieved better performance and faster convergence compared with state-of-the-art methods. The test AUC for the binary tumor classification can be up to 93.09% over CAMELYON16 dataset. And the AUC over the cancer subtypes classification can be up to 96.03% and 98.82% over TCGA-NSCLC dataset and TCGA-RCC dataset, respectively.

The recent proliferation of knowledge graphs (KGs) coupled with incomplete or partial information, in the form of missing relations (links) between entities, has fueled a lot of research on knowledge base completion (also known as relation prediction). Several recent works suggest that convolutional neural network (CNN) based models generate richer and more expressive feature embeddings and hence also perform well on relation prediction. However, we observe that these KG embeddings treat triples independently and thus fail to cover the complex and hidden information that is inherently implicit in the local neighborhood surrounding a triple. To this effect, our paper proposes a novel attention based feature embedding that captures both entity and relation features in any given entity's neighborhood. Additionally, we also encapsulate relation clusters and multihop relations in our model. Our empirical study offers insights into the efficacy of our attention based model and we show marked performance gains in comparison to state of the art methods on all datasets.

Recently, ensemble has been applied to deep metric learning to yield state-of-the-art results. Deep metric learning aims to learn deep neural networks for feature embeddings, distances of which satisfy given constraint. In deep metric learning, ensemble takes average of distances learned by multiple learners. As one important aspect of ensemble, the learners should be diverse in their feature embeddings. To this end, we propose an attention-based ensemble, which uses multiple attention masks, so that each learner can attend to different parts of the object. We also propose a divergence loss, which encourages diversity among the learners. The proposed method is applied to the standard benchmarks of deep metric learning and experimental results show that it outperforms the state-of-the-art methods by a significant margin on image retrieval tasks.