The COVID-19 pandemic left its unique mark on the 21st century as one of the most significant disasters in history, triggering governments all over the world to respond with a wide range of interventions. However, these restrictions come with a substantial price tag. It is crucial for governments to form anti-virus strategies that balance the trade-off between protecting public health and minimizing the economic cost. This work proposes a probabilistic programming method to quantify the efficiency of major non-pharmaceutical interventions. We present a generative simulation model that accounts for the economic and human capital cost of adopting such strategies, and provide an end-to-end pipeline to simulate the virus spread and the incurred loss of various policy combinations. By investigating the national response in 10 countries covering four continents, we found that social distancing coupled with contact tracing is the most successful policy, reducing the virus transmission rate by 96\% along with a 98\% reduction in economic and human capital loss. Together with experimental results, we open-sourced a framework to test the efficacy of each policy combination.
相關內容
From the ad network standpoint, a user's activity is a multi-type sequence of temporal events consisting of event types and time intervals. Understanding user patterns in ad networks has received increasing attention from the machine learning community. Particularly, the problems of fraud detection, Conversion Rate (CVR), and Click-Through Rate (CTR) prediction are of interest. However, the class imbalance between major and minor classes in these tasks can bias a machine learning model leading to poor performance. This study proposes using two multi-type (continuous and discrete) training approaches for GANs to deal with the limitations of traditional GANs in passing the gradient updates for discrete tokens. First, we used the Reinforcement Learning (RL)-based training approach and then, an approximation of the multinomial distribution parameterized in terms of the softmax function (Gumble-Softmax). Our extensive experiments based on synthetic data have shown the trained generator can generate sequences with desired properties measured by multiple criteria.
We study how international flights can facilitate the spread of an epidemic to a worldwide scale. We combine an infrastructure network of flight connections with a population density dataset to derive the mobility network, and then we define an epidemic framework to model the spread of the disease. Our approach combines a compartmental SEIRS model with a graph diffusion model to capture the clusteredness of the distribution of the population. The resulting model is characterised by the dynamics of a metapopulation SEIRS, with amplification or reduction of the infection rate which is determined also by the mobility of individuals. We use simulations to characterise and study a variety of realistic scenarios that resemble the recent spread of COVID-19. Crucially, we define a formal framework that can be used to design epidemic mitigation strategies: we propose an optimisation approach based on genetic algorithms that can be used to identify an optimal airport closure strategy, and that can be employed to aid decision making for the mitigation of the epidemic, in a timely manner.
Digital contact tracing apps for COVID, such as the one developed by Google and Apple, need to estimate the risk that a user was infected during a particular exposure, in order to decide whether to notify the user to take precautions, such as entering into quarantine, or requesting a test. Such risk score models contain numerous parameters that must be set by the public health authority. In this paper, we show how to automatically learn these parameters from data. Our method needs access to exposure and outcome data. Although this data is already being collected (in an aggregated, privacy-preserving way) by several health authorities, in this paper we limit ourselves to simulated data, so that we can systematically study the different factors that affect the feasibility of the approach. In particular, we show that the parameters become harder to estimate when there is more missing data (e.g., due to infections which were not recorded by the app), and when there is model misspecification. Nevertheless, the learning approach outperforms a strong manually designed baseline. Furthermore, the learning approach can adapt even when the risk factors of the disease change, e.g., due to the evolution of new variants, or the adoption of vaccines.
The spread of COVID-19 has been greatly impacted by regulatory policies and behavior patterns that vary across counties, states, and countries. Population-level dynamics of COVID-19 can generally be described using a set of ordinary differential equations, but these deterministic equations are insufficient for modeling the observed case rates, which can vary due to local testing and case reporting policies and non-homogeneous behavior among individuals. To assess the impact of population mobility on the spread of COVID-19, we have developed a novel Bayesian time-varying coefficient state-space model for infectious disease transmission. The foundation of this model is a time-varying coefficient compartment model to recapitulate the dynamics among susceptible, exposed, undetected infectious, detected infectious, undetected removed, detected non-infectious, detected recovered, and detected deceased individuals. The infectiousness and detection parameters are modeled to vary by time, and the infectiousness component in the model incorporates information on multiple sources of population mobility. Along with this compartment model, a multiplicative process model is introduced to allow for deviation from the deterministic dynamics. We apply this model to observed COVID-19 cases and deaths in several US states and Colorado counties. We find that population mobility measures are highly correlated with transmission rates and can explain complicated temporal variation in infectiousness in these regions. Additionally, the inferred connections between mobility and epidemiological parameters, varying across locations, have revealed the heterogeneous effects of different policies on the dynamics of COVID-19.
Coronavirus disease 2019 (COVID-19) pandemic is an unprecedented global public health challenge. In the United States (US), state governments have implemented various non-pharmaceutical interventions (NPIs), such as physical distance closure (lockdown), stay-at-home order, mandatory facial mask in public in response to the rapid spread of COVID-19. To evaluate the effectiveness of these NPIs, we propose a nested case-control design with propensity score weighting under the quasi-experiment framework to estimate the average intervention effect on disease transmission across states. We further develop a method to test for factors that moderate intervention effect to assist precision public health intervention. Our method takes account of the underlying dynamics of disease transmission and balance state-level pre-intervention characteristics. We prove that our estimator provides causal intervention effect under assumptions. We apply this method to analyze US COVID-19 incidence cases to estimate the effects of six interventions. We show that lockdown has the largest effect on reducing transmission and reopening bars significantly increase transmission. States with a higher percentage of non-white population are at greater risk of increased $R_t$ associated with reopening bars.
In this work, we study the pandemic course in the United States by considering national and state levels data. We propose and compare multiple time-series prediction techniques which incorporate auxiliary variables. One type of approach is based on spatio-temporal graph neural networks which forecast the pandemic course by utilizing a hybrid deep learning architecture and human mobility data. Nodes in this graph represent the state-level deaths due to COVID-19, edges represent the human mobility trend and temporal edges correspond to node attributes across time. The second approach is based on a statistical technique for COVID-19 mortality prediction in the United States that uses the SARIMA model and eXogenous variables. We evaluate these techniques on both state and national levels COVID-19 data in the United States and claim that the SARIMA and MCP models generated forecast values by the eXogenous variables can enrich the underlying model to capture complexity in respectively national and state levels data. We demonstrate significant enhancement in the forecasting accuracy for a COVID-19 dataset, with a maximum improvement in forecasting accuracy by 64.58% and 59.18% (on average) over the GCN-LSTM model in the national level data, and 58.79% and 52.40% (on average) over the GCN-LSTM model in the state level data. Additionally, our proposed model outperforms a parallel study (AUG-NN) by 27.35% improvement of accuracy on average.
Introduction: Real-world data generated from clinical practice can be used to analyze the real-world evidence (RWE) of COVID-19 pharmacotherapy and validate the results of randomized clinical trials (RCTs). Machine learning (ML) methods are being used in RWE and are promising tools for precision-medicine. In this study, ML methods are applied to study the efficacy of therapies on COVID-19 hospital admissions in the Valencian Region in Spain. Methods: 5244 and 1312 COVID-19 hospital admissions - dated between January 2020 and January 2021 from 10 health departments, were used respectively for training and validation of separate treatment-effect models (TE-ML) for remdesivir, corticosteroids, tocilizumab, lopinavir-ritonavir, azithromycin and chloroquine/hydroxychloroquine. 2390 admissions from 2 additional health departments were reserved as an independent test to analyze retrospectively the survival benefits of therapies in the population selected by the TE-ML models using cox-proportional hazard models. TE-ML models were adjusted using treatment propensity scores to control for pre-treatment confounding variables associated to outcome and further evaluated for futility. ML architecture was based on boosted decision-trees. Results: In the populations identified by the TE-ML models, only Remdesivir and Tocilizumab were significantly associated with an increase in survival time, with hazard ratios of 0.41 (P = 0.04) and 0.21 (P = 0.001), respectively. No survival benefits from chloroquine derivatives, lopinavir-ritonavir and azithromycin were demonstrated. Tools to explain the predictions of TE-ML models are explored at patient-level as potential tools for personalized decision making and precision medicine. Conclusion: ML methods are suitable tools toward RWE analysis of COVID-19 pharmacotherapies. Results obtained reproduce published results on RWE and validate the results from RCTs.
A fundamental computation for statistical inference and accurate decision-making is to compute the marginal probabilities or most probable states of task-relevant variables. Probabilistic graphical models can efficiently represent the structure of such complex data, but performing these inferences is generally difficult. Message-passing algorithms, such as belief propagation, are a natural way to disseminate evidence amongst correlated variables while exploiting the graph structure, but these algorithms can struggle when the conditional dependency graphs contain loops. Here we use Graph Neural Networks (GNNs) to learn a message-passing algorithm that solves these inference tasks. We first show that the architecture of GNNs is well-matched to inference tasks. We then demonstrate the efficacy of this inference approach by training GNNs on a collection of graphical models and showing that they substantially outperform belief propagation on loopy graphs. Our message-passing algorithms generalize out of the training set to larger graphs and graphs with different structure.
In recommender systems, cold-start issues are situations where no previous events, e.g. ratings, are known for certain users or items. In this paper, we focus on the item cold-start problem. Both content information (e.g. item attributes) and initial user ratings are valuable for seizing users' preferences on a new item. However, previous methods for the item cold-start problem either 1) incorporate content information into collaborative filtering to perform hybrid recommendation, or 2) actively select users to rate the new item without considering content information and then do collaborative filtering. In this paper, we propose a novel recommendation scheme for the item cold-start problem by leverage both active learning and items' attribute information. Specifically, we design useful user selection criteria based on items' attributes and users' rating history, and combine the criteria in an optimization framework for selecting users. By exploiting the feedback ratings, users' previous ratings and items' attributes, we then generate accurate rating predictions for the other unselected users. Experimental results on two real-world datasets show the superiority of our proposed method over traditional methods.
Recommender systems play a crucial role in mitigating the problem of information overload by suggesting users' personalized items or services. The vast majority of traditional recommender systems consider the recommendation procedure as a static process and make recommendations following a fixed strategy. In this paper, we propose a novel recommender system with the capability of continuously improving its strategies during the interactions with users. We model the sequential interactions between users and a recommender system as a Markov Decision Process (MDP) and leverage Reinforcement Learning (RL) to automatically learn the optimal strategies via recommending trial-and-error items and receiving reinforcements of these items from users' feedbacks. In particular, we introduce an online user-agent interacting environment simulator, which can pre-train and evaluate model parameters offline before applying the model online. Moreover, we validate the importance of list-wise recommendations during the interactions between users and agent, and develop a novel approach to incorporate them into the proposed framework LIRD for list-wide recommendations. The experimental results based on a real-world e-commerce dataset demonstrate the effectiveness of the proposed framework.
注冊地址： 北京市海淀區羊坊店路18號2幢3層301-191