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In some medical imaging tasks and other settings where only small parts of the image are informative for the classification task, traditional CNNs can sometimes struggle to generalise. Manually annotated Regions of Interest (ROI) are sometimes used to isolate the most informative parts of the image. However, these are expensive to collect and may vary significantly across annotators. To overcome these issues, we propose a framework that employs saliency maps to obtain soft spatial attention masks that modulate the image features at different scales. We refer to our method as Adversarial Counterfactual Attention (ACAT). ACAT increases the baseline classification accuracy of lesions in brain CT scans from 71.39% to 72.55% and of COVID-19 related findings in lung CT scans from 67.71% to 70.84% and exceeds the performance of competing methods. We investigate the best way to generate the saliency maps employed in our architecture and propose a way to obtain them from adversarially generated counterfactual images. They are able to isolate the area of interest in brain and lung CT scans without using any manual annotations. In the task of localising the lesion location out of 6 possible regions, they obtain a score of 65.05% on brain CT scans, improving the score of 61.29% obtained with the best competing method.

Recent technological advances in synthetic data have enabled the generation of images with such high quality that human beings cannot tell the difference between real-life photographs and Artificial Intelligence (AI) generated images. Given the critical necessity of data reliability and authentication, this article proposes to enhance our ability to recognise AI-generated images through computer vision. Initially, a synthetic dataset is generated that mirrors the ten classes of the already available CIFAR-10 dataset with latent diffusion which provides a contrasting set of images for comparison to real photographs. The model is capable of generating complex visual attributes, such as photorealistic reflections in water. The two sets of data present as a binary classification problem with regard to whether the photograph is real or generated by AI. This study then proposes the use of a Convolutional Neural Network (CNN) to classify the images into two categories; Real or Fake. Following hyperparameter tuning and the training of 36 individual network topologies, the optimal approach could correctly classify the images with 92.98% accuracy. Finally, this study implements explainable AI via Gradient Class Activation Mapping to explore which features within the images are useful for classification. Interpretation reveals interesting concepts within the image, in particular, noting that the actual entity itself does not hold useful information for classification; instead, the model focuses on small visual imperfections in the background of the images. The complete dataset engineered for this study, referred to as the CIFAKE dataset, is made publicly available to the research community for future work.

Anomaly detection is essential in many application domains, such as cyber security, law enforcement, medicine, and fraud protection. However, the decision-making of current deep learning approaches is notoriously hard to understand, which often limits their practical applicability. To overcome this limitation, we propose a framework for learning inherently interpretable anomaly detectors from sequential data. More specifically, we consider the task of learning a deterministic finite automaton (DFA) from a given multi-set of unlabeled sequences. We show that this problem is computationally hard and develop two learning algorithms based on constraint optimization. Moreover, we introduce novel regularization schemes for our optimization problems that improve the overall interpretability of our DFAs. Using a prototype implementation, we demonstrate that our approach shows promising results in terms of accuracy and F1 score.

Current evaluations of Continual Learning (CL) methods typically assume that there is no constraint on training time and computation. This is an unrealistic assumption for any real-world setting, which motivates us to propose: a practical real-time evaluation of continual learning, in which the stream does not wait for the model to complete training before revealing the next data for predictions. To do this, we evaluate current CL methods with respect to their computational costs. We conduct extensive experiments on CLOC, a large-scale dataset containing 39 million time-stamped images with geolocation labels. We show that a simple baseline outperforms state-of-the-art CL methods under this evaluation, questioning the applicability of existing methods in realistic settings. In addition, we explore various CL components commonly used in the literature, including memory sampling strategies and regularization approaches. We find that all considered methods fail to be competitive against our simple baseline. This surprisingly suggests that the majority of existing CL literature is tailored to a specific class of streams that is not practical. We hope that the evaluation we provide will be the first step towards a paradigm shift to consider the computational cost in the development of online continual learning methods.

Class-incremental continual learning is a core step towards developing artificial intelligence systems that can continuously adapt to changes in the environment by learning new concepts without forgetting those previously learned. This is especially needed in the medical domain where continually learning from new incoming data is required to classify an expanded set of diseases. In this work, we focus on how old knowledge can be leveraged to learn new classes without catastrophic forgetting. We propose a framework that comprises of two main components: (1) a dynamic architecture with expanding representations to preserve previously learned features and accommodate new features; and (2) a training procedure alternating between two objectives to balance the learning of new features while maintaining the model's performance on old classes. Experiment results on multiple medical datasets show that our solution is able to achieve superior performance over state-of-the-art baselines in terms of class accuracy and forgetting.

Deep Neural Networks use thousands of mostly incomprehensible features to identify a single class, a decision no human can follow. We propose an interpretable sparse and low dimensional final decision layer in a deep neural network with measurable aspects of interpretability and demonstrate it on fine-grained image classification. We argue that a human can only understand the decision of a machine learning model, if the features are interpretable and only very few of them are used for a single decision. For that matter, the final layer has to be sparse and, to make interpreting the features feasible, low dimensional. We call a model with a Sparse Low-Dimensional Decision SLDD-Model. We show that a SLDD-Model is easier to interpret locally and globally than a dense high-dimensional decision layer while being able to maintain competitive accuracy. Additionally, we propose a loss function that improves a model's feature diversity and accuracy. Our more interpretable SLDD-Model only uses 5 out of just 50 features per class, while maintaining 97% to 100% of the accuracy on four common benchmark datasets compared to the baseline model with 2048 features.

Inspired by the human cognitive system, attention is a mechanism that imitates the human cognitive awareness about specific information, amplifying critical details to focus more on the essential aspects of data. Deep learning has employed attention to boost performance for many applications. Interestingly, the same attention design can suit processing different data modalities and can easily be incorporated into large networks. Furthermore, multiple complementary attention mechanisms can be incorporated in one network. Hence, attention techniques have become extremely attractive. However, the literature lacks a comprehensive survey specific to attention techniques to guide researchers in employing attention in their deep models. Note that, besides being demanding in terms of training data and computational resources, transformers only cover a single category in self-attention out of the many categories available. We fill this gap and provide an in-depth survey of 50 attention techniques categorizing them by their most prominent features. We initiate our discussion by introducing the fundamental concepts behind the success of attention mechanism. Next, we furnish some essentials such as the strengths and limitations of each attention category, describe their fundamental building blocks, basic formulations with primary usage, and applications specifically for computer vision. We also discuss the challenges and open questions related to attention mechanism in general. Finally, we recommend possible future research directions for deep attention.

Following unprecedented success on the natural language tasks, Transformers have been successfully applied to several computer vision problems, achieving state-of-the-art results and prompting researchers to reconsider the supremacy of convolutional neural networks (CNNs) as {de facto} operators. Capitalizing on these advances in computer vision, the medical imaging field has also witnessed growing interest for Transformers that can capture global context compared to CNNs with local receptive fields. Inspired from this transition, in this survey, we attempt to provide a comprehensive review of the applications of Transformers in medical imaging covering various aspects, ranging from recently proposed architectural designs to unsolved issues. Specifically, we survey the use of Transformers in medical image segmentation, detection, classification, reconstruction, synthesis, registration, clinical report generation, and other tasks. In particular, for each of these applications, we develop taxonomy, identify application-specific challenges as well as provide insights to solve them, and highlight recent trends. Further, we provide a critical discussion of the field's current state as a whole, including the identification of key challenges, open problems, and outlining promising future directions. We hope this survey will ignite further interest in the community and provide researchers with an up-to-date reference regarding applications of Transformer models in medical imaging. Finally, to cope with the rapid development in this field, we intend to regularly update the relevant latest papers and their open-source implementations at \url{//github.com/fahadshamshad/awesome-transformers-in-medical-imaging}.

In this paper, we propose a one-stage online clustering method called Contrastive Clustering (CC) which explicitly performs the instance- and cluster-level contrastive learning. To be specific, for a given dataset, the positive and negative instance pairs are constructed through data augmentations and then projected into a feature space. Therein, the instance- and cluster-level contrastive learning are respectively conducted in the row and column space by maximizing the similarities of positive pairs while minimizing those of negative ones. Our key observation is that the rows of the feature matrix could be regarded as soft labels of instances, and accordingly the columns could be further regarded as cluster representations. By simultaneously optimizing the instance- and cluster-level contrastive loss, the model jointly learns representations and cluster assignments in an end-to-end manner. Extensive experimental results show that CC remarkably outperforms 17 competitive clustering methods on six challenging image benchmarks. In particular, CC achieves an NMI of 0.705 (0.431) on the CIFAR-10 (CIFAR-100) dataset, which is an up to 19\% (39\%) performance improvement compared with the best baseline.

The rapid advancements in machine learning, graphics processing technologies and availability of medical imaging data has led to a rapid increase in use of machine learning models in the medical domain. This was exacerbated by the rapid advancements in convolutional neural network (CNN) based architectures, which were adopted by the medical imaging community to assist clinicians in disease diagnosis. Since the grand success of AlexNet in 2012, CNNs have been increasingly used in medical image analysis to improve the efficiency of human clinicians. In recent years, three-dimensional (3D) CNNs have been employed for analysis of medical images. In this paper, we trace the history of how the 3D CNN was developed from its machine learning roots, brief mathematical description of 3D CNN and the preprocessing steps required for medical images before feeding them to 3D CNNs. We review the significant research in the field of 3D medical imaging analysis using 3D CNNs (and its variants) in different medical areas such as classification, segmentation, detection, and localization. We conclude by discussing the challenges associated with the use of 3D CNNs in the medical imaging domain (and the use of deep learning models, in general) and possible future trends in the field.