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For the convolutional neural network (CNN) used for pattern classification, the training loss function is usually applied to the final output of the network, except for some regularization constraints on the network parameters. However, with the increasing of the number of network layers, the influence of the loss function on the network front layers gradually decreases, and the network parameters tend to fall into local optimization. At the same time, it is found that the trained network has significant information redundancy at all stages of features, which reduces the effectiveness of feature mapping at all stages and is not conducive to the change of the subsequent parameters of the network in the direction of optimality. Therefore, it is possible to obtain a more optimized solution of the network and further improve the classification accuracy of the network by designing a loss function for restraining the front stage features and eliminating the information redundancy of the front stage features .For CNN, this article proposes a multi-stage feature decorrelation loss (MFD Loss), which refines effective features and eliminates information redundancy by constraining the correlation of features at all stages. Considering that there are many layers in CNN, through experimental comparison and analysis, MFD Loss acts on multiple front layers of CNN, constrains the output features of each layer and each channel, and performs supervision training jointly with classification loss function during network training. Compared with the single Softmax Loss supervised learning, the experiments on several commonly used datasets on several typical CNNs prove that the classification performance of Softmax Loss+MFD Loss is significantly better. Meanwhile, the comparison experiments before and after the combination of MFD Loss and some other typical loss functions verify its good universality.

Over the past decade, the value and potential of VR applications in manufacturing have gained significant attention in accordance with the rise of Industry 4.0 and beyond. Its efficacy in layout planning, virtual design reviews, and operator training has been well-established in previous studies. However, many functional requirements and interaction parameters of VR for manufacturing remain ambiguously defined. One area awaiting exploration is spatial recognition and learning, crucial for understanding navigation within the virtual manufacturing system and processing spatial data. This is particularly vital in multi-user VR applications where participants' spatial awareness in the virtual realm significantly influences the efficiency of meetings and design reviews. This paper investigates the interaction parameters of multi-user VR, focusing on interactive positioning maps for virtual factory layout planning and exploring the user interaction design of digital maps as navigation aid. A literature study was conducted in order to establish frequently used technics and interactive maps from the VR gaming industry. Multiple demonstrators of different interactive maps provide a comprehensive A/B test which were implemented into a VR multi-user platform using the Unity game engine. Five different prototypes of interactive maps were tested, evaluated and graded by the 20 participants and 40 validated data streams collected. The most efficient interaction design of interactive maps is thus analyzed and discussed in the study.

When studying the association between treatment and a clinical outcome, a parametric multivariable model of the conditional outcome expectation is often used to adjust for covariates. The treatment coefficient of the outcome model targets a conditional treatment effect. Model-based standardization is typically applied to average the model predictions over the target covariate distribution, and generate a covariate-adjusted estimate of the marginal treatment effect. The standard approach to model-based standardization involves maximum-likelihood estimation and use of the non-parametric bootstrap. We introduce a novel, general-purpose, model-based standardization method based on multiple imputation that is easily applicable when the outcome model is a generalized linear model. We term our proposed approach multiple imputation marginalization (MIM). MIM consists of two main stages: the generation of synthetic datasets and their analysis. MIM accommodates a Bayesian statistical framework, which naturally allows for the principled propagation of uncertainty, integrates the analysis into a probabilistic framework, and allows for the incorporation of prior evidence. We conduct a simulation study to benchmark the finite-sample performance of MIM in conjunction with a parametric outcome model. The simulations provide proof-of-principle in scenarios with binary outcomes, continuous-valued covariates, a logistic outcome model and the marginal log odds ratio as the target effect measure. When parametric modeling assumptions hold, MIM yields unbiased estimation in the target covariate distribution, valid coverage rates, and similar precision and efficiency than the standard approach to model-based standardization.

Detecting differences in gene expression is an important part of single-cell RNA sequencing experiments, and many statistical methods have been developed for this aim. Most differential expression analyses focus on comparing expression between two groups (e.g., treatment vs. control). But there is increasing interest in multi-condition differential expression analyses in which expression is measured in many conditions, and the aim is to accurately detect and estimate expression differences in all conditions. We show that directly modeling single-cell RNA-seq counts in all conditions simultaneously, while also inferring how expression differences are shared across conditions, leads to greatly improved performance for detecting and estimating expression differences compared to existing methods. We illustrate the potential of this new approach by analyzing data from a single-cell experiment studying the effects of cytokine stimulation on gene expression. We call our new method "Poisson multivariate adaptive shrinkage", and it is implemented in an R package available online at //github.com/stephenslab/poisson.mash.alpha.

This work focuses on the task of property targeting: that is, generating molecules conditioned on target chemical properties to expedite candidate screening for novel drug and materials development. DiGress is a recent diffusion model for molecular graphs whose distinctive feature is allowing property targeting through classifier-based (CB) guidance. While CB guidance may work to generate molecular-like graphs, we hint at the fact that its assumptions apply poorly to the chemical domain. Based on this insight we propose a classifier-free DiGress (FreeGress), which works by directly injecting the conditioning information into the training process. CF guidance is convenient given its less stringent assumptions and since it does not require to train an auxiliary property regressor, thus halving the number of trainable parameters in the model. We empirically show that our model yields up to 79% improvement in Mean Absolute Error with respect to DiGress on property targeting tasks on QM9 and ZINC-250k benchmarks. As an additional contribution, we propose a simple yet powerful approach to improve chemical validity of generated samples, based on the observation that certain chemical properties such as molecular weight correlate with the number of atoms in molecules.

Multi-modal Magnetic Resonance Imaging (MRI) offers complementary diagnostic information, but some modalities are limited by the long scanning time. To accelerate the whole acquisition process, MRI reconstruction of one modality from highly undersampled k-space data with another fully-sampled reference modality is an efficient solution. However, the misalignment between modalities, which is common in clinic practice, can negatively affect reconstruction quality. Existing deep learning-based methods that account for inter-modality misalignment perform better, but still share two main common limitations: (1) The spatial alignment task is not adaptively integrated with the reconstruction process, resulting in insufficient complementarity between the two tasks; (2) the entire framework has weak interpretability. In this paper, we construct a novel Deep Unfolding Network with Spatial Alignment, termed DUN-SA, to appropriately embed the spatial alignment task into the reconstruction process. Concretely, we derive a novel joint alignment-reconstruction model with a specially designed cross-modal spatial alignment term. By relaxing the model into cross-modal spatial alignment and multi-modal reconstruction tasks, we propose an effective algorithm to solve this model alternatively. Then, we unfold the iterative steps of the proposed algorithm and design corresponding network modules to build DUN-SA with interpretability. Through end-to-end training, we effectively compensate for spatial misalignment using only reconstruction loss, and utilize the progressively aligned reference modality to provide inter-modality prior to improve the reconstruction of the target modality. Comprehensive experiments on three real datasets demonstrate that our method exhibits superior reconstruction performance compared to state-of-the-art methods.

Breast cancer continues to be a significant cause of mortality among women globally. Timely identification and precise diagnosis of breast abnormalities are critical for enhancing patient prognosis. In this study, we focus on improving the early detection and accurate diagnosis of breast abnormalities, which is crucial for improving patient outcomes and reducing the mortality rate of breast cancer. To address the limitations of traditional screening methods, a novel unsupervised feature correlation network was developed to predict maps indicating breast abnormal variations using longitudinal 2D mammograms. The proposed model utilizes the reconstruction process of current year and prior year mammograms to extract tissue from different areas and analyze the differences between them to identify abnormal variations that may indicate the presence of cancer. The model is equipped with a feature correlation module, an attention suppression gate, and a breast abnormality detection module that work together to improve the accuracy of the prediction. The proposed model not only provides breast abnormal variation maps, but also distinguishes between normal and cancer mammograms, making it more advanced compared to the state-of the-art baseline models. The results of the study show that the proposed model outperforms the baseline models in terms of Accuracy, Sensitivity, Specificity, Dice score, and cancer detection rate.

Permutation tests are widely recognized as robust alternatives to tests based on normal theory. Random permutation tests have been frequently employed to assess the significance of variables in linear models. Despite their widespread use, existing random permutation tests lack finite-sample and assumption-free guarantees for controlling type I error in partial correlation tests. To address this ongoing challenge, we have developed a conformal test through permutation-augmented regressions, which we refer to as PALMRT. PALMRT not only achieves power competitive with conventional methods but also provides reliable control of type I errors at no more than $2\alpha$, given any targeted level $\alpha$, for arbitrary fixed designs and error distributions. We have confirmed this through extensive simulations. Compared to the cyclic permutation test (CPT) and residual permutation test (RPT), which also offer theoretical guarantees, PALMRT does not compromise as much on power or set stringent requirements on the sample size, making it suitable for diverse biomedical applications. We further illustrate the differences in a long-Covid study where PALMRT validated key findings previously identified using the t-test after multiple corrections, while both CPT and RPT suffered from a drastic loss of power and failed to identify any discoveries. We endorse PALMRT as a robust and practical hypothesis test in scientific research for its superior error control, power preservation, and simplicity. An R package for PALMRT is available at \url{//github.com/LeyingGuan/PairedRegression}.

A rank-invariant clustering of variables is introduced that is based on the predictive strength between groups of variables, i.e., two groups are assigned a high similarity if the variables in the first group contain high predictive information about the behaviour of the variables in the other group and/or vice versa. The method presented here is model-free, dependence-based and does not require any distributional assumptions. Various general invariance and continuity properties are investigated, with special attention to those that are beneficial for the agglomerative hierarchical clustering procedure. A fully non-parametric estimator is considered whose excellent performance is demonstrated in several simulation studies and by means of real-data examples.

In recent literature, for modeling reasons, fractional differential problems have been considered equipped with anti-symmetric boundary conditions. Twenty years ago the anti-reflective boundary conditions were introduced in a context of signal processing and imaging for increasing the quality of the reconstruction of a blurred signal/image contaminated by noise and for reducing the overall complexity to that of few fast sine transforms i.e. to $O(N\log N)$ real arithmetic operations, where $N$ is the number of pixels. Here we consider the anti-symmetric boundary conditions and we introduce the anti-reflective boundary conditions in the context of nonlocal problems of fractional differential type. In the latter context, we study both types of boundary conditions, which in reality are similar in the essentials, from the perspective of computational efficiency, by considering nontruncated and truncated versions. Several numerical tests, tables, and visualizations are provided and critically discussed.