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Machine learning is increasingly used to discover diagnostic and prognostic biomarkers from high-dimensional molecular data. However, a variety of factors related to experimental design may affect the ability to learn generalizable and clinically applicable diagnostics. Here, we argue that a causal perspective improves the identification of these challenges, and formalizes their relation to the robustness and generalization of machine learning-based diagnostics. To make for a concrete discussion, we focus on a specific, recently established high-dimensional biomarker - adaptive immune receptor repertoires (AIRRs). We discuss how the main biological and experimental factors of the AIRR domain may influence the learned biomarkers and provide easily adjustable simulations of such effects. In conclusion, we find that causal modeling improves machine learning-based biomarker robustness by identifying stable relations between variables and by guiding the adjustment of the relations and variables that vary between populations.

We present a method to simulate movement in interaction with computers, using Model Predictive Control (MPC). The method starts from understanding interaction from an Optimal Feedback Control (OFC) perspective. We assume that users aim to minimize an internalized cost function, subject to the constraints imposed by the human body and the interactive system. In contrast to previous linear approaches used in HCI, MPC can compute optimal controls for nonlinear systems. This allows us to use state-of-the-art biomechanical models and handle nonlinearities that occur in almost any interactive system. Instead of torque actuation, our model employs second-order muscles acting directly at the joints. We compare three different cost functions and evaluate the simulated trajectories against user movements in a Fitts' Law type pointing study with four different interaction techniques. Our results show that the combination of distance, control, and joint acceleration cost matches individual users' movements best, and predicts movements with an accuracy that is within the between-user variance. To aid HCI researchers and designers, we introduce CFAT, a novel method to identify maximum voluntary torques in joint-actuated models based on experimental data, and give practical advice on how to simulate human movement for different users, interaction techniques, and tasks.

The most common sensing modalities found in a robot perception system are vision and touch, which together can provide global and highly localized data for manipulation. However, these sensing modalities often fail to adequately capture the behavior of target objects during the critical moments as they transition out of static, controlled contact with an end-effector to dynamic and uncontrolled motion. In this work, we present a novel multimodal visuotactile sensor that provides simultaneous visuotactile and proximity depth data. The sensor integrates an RGB camera and air pressure sensor to sense touch with an infrared time-of-flight (ToF) camera to sense proximity by leveraging a selectively transmissive soft membrane to enable the dual sensing modalities. We present the mechanical design, fabrication techniques, algorithm implementations, and evaluation of the sensor's tactile and proximity modalities. The sensor is demonstrated in three open-loop robotic tasks: approaching and contacting an object, catching, and throwing. The fusion of tactile and proximity data could be used to capture key information about a target object's transition behavior for sensor-based control in dynamic manipulation.

We study how visual representations pre-trained on diverse human video data can enable data-efficient learning of downstream robotic manipulation tasks. Concretely, we pre-train a visual representation using the Ego4D human video dataset using a combination of time-contrastive learning, video-language alignment, and an L1 penalty to encourage sparse and compact representations. The resulting representation, R3M, can be used as a frozen perception module for downstream policy learning. Across a suite of 12 simulated robot manipulation tasks, we find that R3M improves task success by over 20% compared to training from scratch and by over 10% compared to state-of-the-art visual representations like CLIP and MoCo. Furthermore, R3M enables a Franka Emika Panda arm to learn a range of manipulation tasks in a real, cluttered apartment given just 20 demonstrations. Code and pre-trained models are available at //tinyurl.com/robotr3m.

The goal of imitation learning is to mimic expert behavior from demonstrations, without access to an explicit reward signal. A popular class of approach infers the (unknown) reward function via inverse reinforcement learning (IRL) followed by maximizing this reward function via reinforcement learning (RL). The policies learned via these approaches are however very brittle in practice and deteriorate quickly even with small test-time perturbations due to compounding errors. We propose Imitation with Planning at Test-time (IMPLANT), a new meta-algorithm for imitation learning that utilizes decision-time planning to correct for compounding errors of any base imitation policy. In contrast to existing approaches, we retain both the imitation policy and the rewards model at decision-time, thereby benefiting from the learning signal of the two components. Empirically, we demonstrate that IMPLANT significantly outperforms benchmark imitation learning approaches on standard control environments and excels at zero-shot generalization when subject to challenging perturbations in test-time dynamics.

Collision avoidance is a widely investigated topic in robotic applications. When applying collision avoidance techniques to a mobile robot, how to deal with the spatial structure of the robot still remains a challenge. In this paper, we design a configuration-aware safe control law by solving a Quadratic Programming (QP) with designed Control Barrier Functions (CBFs) constraints, which can safely navigate a mobile robotic arm to a desired region while avoiding collision with environmental obstacles. The advantage of our approach is that it correctly and in an elegant way incorporates the spatial structure of the mobile robotic arm. This is achieved by merging geometric restrictions among mobile robotic arm links into CBFs constraints. Simulations on a rigid rod and the modeled mobile robotic arm are performed to verify the feasibility and time-efficiency of proposed method. Numerical results about the time consuming for different degrees of freedom illustrate that our method scales well with dimension.

Perceiving and interacting with 3D articulated objects, such as cabinets, doors, and faucets, pose particular challenges for future home-assistant robots performing daily tasks in human environments. Besides parsing the articulated parts and joint parameters, researchers recently advocate learning manipulation affordance over the input shape geometry which is more task-aware and geometrically fine-grained. However, taking only passive observations as inputs, these methods ignore many hidden but important kinematic constraints (e.g., joint location and limits) and dynamic factors (e.g., joint friction and restitution), therefore losing significant accuracy for test cases with such uncertainties. In this paper, we propose a novel framework, named AdaAfford, that learns to perform very few test-time interactions for quickly adapting the affordance priors to more accurate instance-specific posteriors. We conduct large-scale experiments using the PartNet-Mobility dataset and prove that our system performs better than baselines.

Imitation learning is a promising approach to help robots acquire dexterous manipulation capabilities without the need for a carefully-designed reward or a significant computational effort. However, existing imitation learning approaches require sophisticated data collection infrastructure and struggle to generalize beyond the training distribution. One way to address this limitation is to gather additional data that better represents the full operating conditions. In this work, we investigate characteristics of such additional demonstrations and their impact on performance. Specifically, we study the effects of corrective and randomly-sampled additional demonstrations on learning a policy that guides a five-fingered robot hand through a pick-and-place task. Our results suggest that corrective demonstrations considerably outperform randomly-sampled demonstrations, when the proportion of additional demonstrations sampled from the full task distribution is larger than the number of original demonstrations sampled from a restrictive training distribution. Conversely, when the number of original demonstrations are higher than that of additional demonstrations, we find no significant differences between corrective and randomly-sampled additional demonstrations. These results provide insights into the inherent trade-off between the effort required to collect corrective demonstrations and their relative benefits over randomly-sampled demonstrations. Additionally, we show that inexpensive vision-based sensors, such as LeapMotion, can be used to dramatically reduce the cost of providing demonstrations for dexterous manipulation tasks. Our code is available at //github.com/GT-STAR-Lab/corrective-demos-dexterous-manipulation.

Soft robots are promising for manipulation tasks thanks to their compliance, safety, and high degree of freedom. However, the commonly used bidirectional continuum segment design means soft robotic manipulators only function in a limited hemispherical workspace. This work increases a soft robotic arm's workspace by designing, fabricating, and controlling an additional soft prismatic actuator at the base of the soft arm. This actuator consists of pneumatic artificial muscles and a piston, making the actuator back-driveable. We increase the task space volume by 116\%, and we are now able to perform manipulation tasks that were previously impossible for soft robots, such as picking and placing objects at different positions on a surface and grabbing an object out of a container. By combining a soft robotic arm with a prismatic joint, we greatly increase the usability of soft robots for object manipulation. This work promotes the use of integrated and modular soft robotic systems for practical manipulation applications in human-centered environments.

Soft robotic grippers facilitate contact-rich manipulation, including robust grasping of varied objects. Yet the beneficial compliance of a soft gripper also results in significant deformation that can make precision manipulation challenging. We present visual pressure estimation & control (VPEC), a method that uses a single RGB image of an unmodified soft gripper from an external camera to directly infer pressure applied to the world by the gripper. We present inference results for a pneumatic gripper and a tendon-actuated gripper making contact with a flat surface. We also show that VPEC enables precision manipulation via closed-loop control of inferred pressure. We present results for a mobile manipulator (Stretch RE1 from Hello Robot) using visual servoing to do the following: achieve target pressures when making contact; follow a spatial pressure trajectory; and grasp small objects, including a microSD card, a washer, a penny, and a pill. Overall, our results show that VPEC enables grippers with high compliance to perform precision manipulation.