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LGBTQ+ individuals are increasingly turning to chatbots powered by large language models (LLMs) to meet their mental health needs. However, little research has explored whether these chatbots can adequately and safely provide tailored support for this demographic. We interviewed 18 LGBTQ+ and 13 non-LGBTQ+ participants about their experiences with LLM-based chatbots for mental health needs. LGBTQ+ participants relied on these chatbots for mental health support, likely due to an absence of support in real life. Notably, while LLMs offer prompt support, they frequently fall short in grasping the nuances of LGBTQ-specific challenges. Although fine-tuning LLMs to address LGBTQ+ needs can be a step in the right direction, it isn't the panacea. The deeper issue is entrenched in societal discrimination. Consequently, we call on future researchers and designers to look beyond mere technical refinements and advocate for holistic strategies that confront and counteract the societal biases burdening the LGBTQ+ community.

Cellular reprogramming can be used for both the prevention and cure of different diseases. However, the efficiency of discovering reprogramming strategies with classical wet-lab experiments is hindered by lengthy time commitments and high costs. In this study, we develop a~novel computational framework based on deep reinforcement learning that facilitates the identification of reprogramming strategies. For this aim, we formulate a~control problem in the context of cellular reprogramming for the frameworks of BNs and PBNs under the asynchronous update mode. Furthermore, we introduce the notion of a~pseudo-attractor and a~procedure for identification of pseudo-attractor state during training. Finally, we devise a~computational framework for solving the control problem, which we test on a~number of different models.

Machine Learning (ML) and 'Artificial Intelligence' ('AI') methods tend to replicate and amplify existing biases and prejudices, as do Robots with AI. For example, robots with facial recognition have failed to identify Black Women as human, while others have categorized people, such as Black Men, as criminals based on appearance alone. A 'culture of modularity' means harms are perceived as 'out of scope', or someone else's responsibility, throughout employment positions in the 'AI supply chain'. Incidents are routine enough (incidentdatabase.ai lists over 2000 examples) to indicate that few organizations are capable of completely respecting peoples' rights; meeting claimed equity, diversity, and inclusion (EDI or DEI) goals; or recognizing and then addressing such failures in their organizations and artifacts. We propose a framework for adapting widely practiced Research and Development (R&D) project management methodologies to build organizational equity capabilities and better integrate known evidence-based best practices. We describe how project teams can organize and operationalize the most promising practices, skill sets, organizational cultures, and methods to detect and address rights-based fairness, equity, accountability, and ethical problems as early as possible when they are often less harmful and easier to mitigate; then monitor for unforeseen incidents to adaptively and constructively address them. Our primary example adapts an Agile development process based on Scrum, one of the most widely adopted approaches to organizing R&D teams. We also discuss limitations of our proposed framework and future research directions.

Correlation clustering is a well-known unsupervised learning setting that deals with positive and negative pairwise similarities. In this paper, we study the case where the pairwise similarities are not given in advance and must be queried in a cost-efficient way. Thereby, we develop a generic active learning framework for this task that benefits from several advantages, e.g., flexibility in the type of feedback that a user/annotator can provide, adaptation to any correlation clustering algorithm and query strategy, and robustness to noise. In addition, we propose and analyze a number of novel query strategies suited to this setting. We demonstrate the effectiveness of our framework and the proposed query strategies via several experimental studies.

This study proposes a method for knowledge distillation (KD) of fine-tuned Large Language Models (LLMs) into smaller, more efficient, and accurate neural networks. We specifically target the challenge of deploying these models on resource-constrained devices. Our methodology involves training the smaller student model (Neural Network) using the prediction probabilities (as soft labels) of the LLM, which serves as a teacher model. This is achieved through a specialized loss function tailored to learn from the LLM's output probabilities, ensuring that the student model closely mimics the teacher's performance. To validate the performance of the KD approach, we utilized a large dataset, 7T, containing 6,684 student-written responses to science questions and three mathematical reasoning datasets with student-written responses graded by human experts. We compared accuracy with state-of-the-art (SOTA) distilled models, TinyBERT, and artificial neural network (ANN) models. Results have shown that the KD approach has 1% and 4% higher scoring accuracy than ANN and TinyBERT and comparable accuracy to the teacher model. Furthermore, the student model size is 0.02M, 10,000 times smaller in parameters and x10 faster in inferencing than the teacher model and TinyBERT, respectively. The significance of this research lies in its potential to make advanced AI technologies accessible in typical educational settings, particularly for automatic scoring.

Electronic health records (EHR) is an inherently multimodal register of the patient's health status characterized by static data and multivariate time series (MTS). While MTS are a valuable tool for clinical prediction, their fusion with other data modalities can possibly result in more thorough insights and more accurate results. Deep neural networks (DNNs) have emerged as fundamental tools for identifying and defining underlying patterns in the healthcare domain. However, fundamental improvements in interpretability are needed for DNN models to be widely used in the clinical setting. In this study, we present an approach built on a collection of interpretable multimodal data-driven models that may anticipate and understand the emergence of antimicrobial multidrug resistance (AMR) germs in the intensive care unit (ICU) of the University Hospital of Fuenlabrada (Madrid, Spain). The profile and initial health status of the patient are modeled using static variables, while the evolution of the patient's health status during the ICU stay is modeled using several MTS, including mechanical ventilation and antibiotics intake. The multimodal DNNs models proposed in this paper include interpretable principles in addition to being effective at predicting AMR and providing an explainable prediction support system for AMR in the ICU. Furthermore, our proposed methodology based on multimodal models and interpretability schemes can be leveraged in additional clinical problems dealing with EHR data, broadening the impact and applicability of our results.

Motivation: We explored how explainable artificial intelligence (XAI) can help to shed light into the inner workings of neural networks for protein function prediction, by extending the widely used XAI method of integrated gradients such that latent representations inside of transformer models, which were finetuned to Gene Ontology term and Enzyme Commission number prediction, can be inspected too. Results: The approach enabled us to identify amino acids in the sequences that the transformers pay particular attention to, and to show that these relevant sequence parts reflect expectations from biology and chemistry, both in the embedding layer and inside of the model, where we identified transformer heads with a statistically significant correspondence of attribution maps with ground truth sequence annotations (e.g. transmembrane regions, active sites) across many proteins. Availability and Implementation: Source code can be accessed at //github.com/markuswenzel/xai-proteins .

Understanding causality helps to structure interventions to achieve specific goals and enables predictions under interventions. With the growing importance of learning causal relationships, causal discovery tasks have transitioned from using traditional methods to infer potential causal structures from observational data to the field of pattern recognition involved in deep learning. The rapid accumulation of massive data promotes the emergence of causal search methods with brilliant scalability. Existing summaries of causal discovery methods mainly focus on traditional methods based on constraints, scores and FCMs, there is a lack of perfect sorting and elaboration for deep learning-based methods, also lacking some considers and exploration of causal discovery methods from the perspective of variable paradigms. Therefore, we divide the possible causal discovery tasks into three types according to the variable paradigm and give the definitions of the three tasks respectively, define and instantiate the relevant datasets for each task and the final causal model constructed at the same time, then reviews the main existing causal discovery methods for different tasks. Finally, we propose some roadmaps from different perspectives for the current research gaps in the field of causal discovery and point out future research directions.

Clinical Named Entity Recognition (CNER) aims to identify and classify clinical terms such as diseases, symptoms, treatments, exams, and body parts in electronic health records, which is a fundamental and crucial task for clinical and translational research. In recent years, deep neural networks have achieved significant success in named entity recognition and many other Natural Language Processing (NLP) tasks. Most of these algorithms are trained end to end, and can automatically learn features from large scale labeled datasets. However, these data-driven methods typically lack the capability of processing rare or unseen entities. Previous statistical methods and feature engineering practice have demonstrated that human knowledge can provide valuable information for handling rare and unseen cases. In this paper, we address the problem by incorporating dictionaries into deep neural networks for the Chinese CNER task. Two different architectures that extend the Bi-directional Long Short-Term Memory (Bi-LSTM) neural network and five different feature representation schemes are proposed to handle the task. Computational results on the CCKS-2017 Task 2 benchmark dataset show that the proposed method achieves the highly competitive performance compared with the state-of-the-art deep learning methods.