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Many methods for estimating integrated volatility and related functionals of semimartingales in the presence of jumps require specification of tuning parameters for their use in practice. In much of the available theory, tuning parameters are assumed to be deterministic and their values are specified only up to asymptotic constraints. However, in empirical work and in simulation studies, they are typically chosen to be random and data-dependent, with explicit choices often relying entirely on heuristics. In this paper, we consider novel data-driven tuning procedures for the truncated realized variations of a semimartingale with jumps based on a type of random fixed-point iteration. Being effectively automated, our approach alleviates the need for delicate decision-making regarding tuning parameters in practice and can be implemented using information regarding sampling frequency alone. We show our methods can lead to asymptotically efficient estimation of integrated volatility and exhibit superior finite-sample performance compared to popular alternatives in the literature.

In Multi-objective Reinforcement Learning (MORL) agents are tasked with optimising decision-making behaviours that trade-off between multiple, possibly conflicting, objectives. MORL based on decomposition is a family of solution methods that employ a number of utility functions to decompose the multi-objective problem into individual single-objective problems solved simultaneously in order to approximate a Pareto front of policies. We focus on the case of linear utility functions parameterised by weight vectors w. We introduce a method based on Upper Confidence Bound to efficiently search for the most promising weight vectors during different stages of the learning process, with the aim of maximising the hypervolume of the resulting Pareto front. The proposed method is shown to outperform various MORL baselines on Mujoco benchmark problems across different random seeds. The code is online at: //github.com/SYCAMORE-1/ucb-MOPPO.

We study three kinetic Langevin samplers including the Euler discretization, the BU and the UBU splitting scheme. We provide contraction results in $L^1$-Wasserstein distance for non-convex potentials. These results are based on a carefully tailored distance function and an appropriate coupling construction. Additionally, the error in the $L^1$-Wasserstein distance between the true target measure and the invariant measure of the discretization scheme is bounded. To get an $\varepsilon$-accuracy in $L^1$-Wasserstein distance, we show complexity guarantees of order $\mathcal{O}(\sqrt{d}/\varepsilon)$ for the Euler scheme and $\mathcal{O}(d^{1/4}/\sqrt{\varepsilon})$ for the UBU scheme under appropriate regularity assumptions on the target measure. The results are applicable to interacting particle systems and provide bounds for sampling probability measures of mean-field type.

Deep learning has enabled breakthroughs in automated diagnosis from medical imaging, with many successful applications in ophthalmology. However, standard medical image classification approaches only assess disease presence at the time of acquisition, neglecting the common clinical setting of longitudinal imaging. For slow, progressive eye diseases like age-related macular degeneration (AMD) and primary open-angle glaucoma (POAG), patients undergo repeated imaging over time to track disease progression and forecasting the future risk of developing disease is critical to properly plan treatment. Our proposed Longitudinal Transformer for Survival Analysis (LTSA) enables dynamic disease prognosis from longitudinal medical imaging, modeling the time to disease from sequences of fundus photography images captured over long, irregular time periods. Using longitudinal imaging data from the Age-Related Eye Disease Study (AREDS) and Ocular Hypertension Treatment Study (OHTS), LTSA significantly outperformed a single-image baseline in 19/20 head-to-head comparisons on late AMD prognosis and 18/20 comparisons on POAG prognosis. A temporal attention analysis also suggested that, while the most recent image is typically the most influential, prior imaging still provides additional prognostic value.

This paper addresses the problem of pathological lung segmentation, a significant challenge in medical image analysis, particularly pronounced in cases of peripheral opacities (severe fibrosis and consolidation) because of the textural similarity between lung tissue and surrounding areas. To overcome these challenges, this paper emphasizes the use of CycleGAN for unpaired image-to-image translation, in order to provide an augmentation method able to generate fake pathological images matching an existing ground truth. Although previous studies have employed CycleGAN, they often neglect the challenge of shape deformation, which is crucial for accurate medical image segmentation. Our work introduces an innovative strategy that incorporates additional loss functions. Specifically, it proposes an L1 loss based on the lung surrounding which shape is constrained to remain unchanged at the transition from the healthy to pathological domains. The lung surrounding is derived based on ground truth lung masks available in the healthy domain. Furthermore, preprocessing steps, such as cropping based on ribs/vertebra locations, are applied to refine the input for the CycleGAN, ensuring that the network focus on the lung region. This is essential to avoid extraneous biases, such as the zoom effect bias, which can divert attention from the main task. The method is applied to enhance in semi-supervised manner the lung segmentation process by employing a U-Net model trained with on-the-fly data augmentation incorporating synthetic pathological tissues generated by the CycleGAN model. Preliminary results from this research demonstrate significant qualitative and quantitative improvements, setting a new benchmark in the field of pathological lung segmentation. Our code is available at //github.com/noureddinekhiati/Semi-supervised-lung-segmentation

mHealth interventions show significant potential to help in the self-management of chronic diseases, but their under use remains a problem. Considering the substantial diversity among individuals dealing with chronic diseases, tailored strategies are essential. \emph{Adaptive User Interfaces} (AUIs) may help address the diverse and evolving needs of this demographic. To investigate this approach, we developed an AUI prototype informed by existing literature findings. We then used this prototype as the basis for focus group discussions and interview studies with 22 participants managing various chronic diseases, and follow-up surveys of all participants. Through these investigations, we pinpointed key challenges related to the use of AUIs, strategies to improve adaptation design, and potential trade-offs between these challenges and strategies. Concurrently, a quantitative survey was conducted to extract preferences for AUIs in chronic disease-related applications with 90 further participants. This uncovered participants' preferences for various adaptations, data types, collection methods, and involvement levels. Finally, we synthesised these insights and categories, aligning them with existing guidelines and design considerations for mHealth app adaptation design. This resulted in nine guidelines that we refined by a final feedback survey conducted with 20 participants.

Popular regularizers with non-differentiable penalties, such as Lasso, Elastic Net, Generalized Lasso, or SLOPE, reduce the dimension of the parameter space by inducing sparsity or clustering in the estimators' coordinates. In this paper, we focus on linear regression and explore the asymptotic distributions of the resulting low-dimensional patterns when the number of regressors $p$ is fixed, the number of observations $n$ goes to infinity, and the penalty function increases at the rate of $\sqrt{n}$. While the asymptotic distribution of the rescaled estimation error can be derived by relatively standard arguments, the convergence of the pattern does not simply follow from the convergence in distribution, and requires a careful and separate treatment. For this purpose, we use the Hausdorff distance as a suitable mode of convergence for subdifferentials, resulting in the desired pattern convergence. Furthermore, we derive the exact limiting probability of recovering the true model pattern. This probability goes to 1 if and only if the penalty scaling constant diverges to infinity and the regularizer-specific asymptotic irrepresentability condition is satisfied. We then propose simple two-step procedures that asymptotically recover the model patterns, irrespective whether the irrepresentability condition holds. Interestingly, our theory shows that Fused Lasso cannot reliably recover its own clustering pattern, even for independent regressors. It also demonstrates how this problem can be resolved by ``concavifying'' the Fused Lasso penalty coefficients. Additionally, sampling from the asymptotic error distribution facilitates comparisons between different regularizers. We provide short simulation studies showcasing an illustrative comparison between the asymptotic properties of Lasso, Fused Lasso, and SLOPE.

This work focuses on accelerating the multiplication of a dense random matrix with a (fixed) sparse matrix, which is frequently used in sketching algorithms. We develop a novel scheme that takes advantage of blocking and recomputation (on-the-fly random number generation) to accelerate this operation. The techniques we propose decrease memory movement, thereby increasing the algorithm's parallel scalability in shared memory architectures. On the Intel Frontera architecture, our algorithm can achieve 2x speedups over libraries such as Eigen and Intel MKL on some examples. In addition, with 32 threads, we can obtain a parallel efficiency of up to approximately 45%. We also present a theoretical analysis for the memory movement lower bound of our algorithm, showing that under mild assumptions, it's possible to beat the data movement lower bound of general matrix-matrix multiply (GEMM) by a factor of $\sqrt M$, where $M$ is the cache size. Finally, we incorporate our sketching algorithm into a randomized least squares solver. For extremely over-determined sparse input matrices, we show that our results are competitive with SuiteSparse; in some cases, we obtain a speedup of 10x over SuiteSparse.

Out of the participants in a randomized experiment with anticipated heterogeneous treatment effects, is it possible to identify which subjects have a positive treatment effect? While subgroup analysis has received attention, claims about individual participants are much more challenging. We frame the problem in terms of multiple hypothesis testing: each individual has a null hypothesis (stating that the potential outcomes are equal, for example) and we aim to identify those for whom the null is false (the treatment potential outcome stochastically dominates the control one, for example). We develop a novel algorithm that identifies such a subset, with nonasymptotic control of the false discovery rate (FDR). Our algorithm allows for interaction -- a human data scientist (or a computer program) may adaptively guide the algorithm in a data-dependent manner to gain power. We show how to extend the methods to observational settings and achieve a type of doubly-robust FDR control. We also propose several extensions: (a) relaxing the null to nonpositive effects, (b) moving from unpaired to paired samples, and (c) subgroup identification. We demonstrate via numerical experiments and theoretical analysis that the proposed method has valid FDR control in finite samples and reasonably high identification power.