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Early warnings for dynamical transitions in complex systems or high-dimensional observation data are essential in many real world applications, such as gene mutation, brain diseases, natural disasters, financial crises, and engineering reliability. To effectively extract early warning signals, we develop a novel approach: the directed anisotropic diffusion map that captures the latent evolutionary dynamics in low-dimensional manifold. Applying the methodology to authentic electroencephalogram (EEG) data, we successfully find the appropriate effective coordinates, and derive early warning signals capable of detecting the tipping point during the state transition. Our method bridges the latent dynamics with the original dataset. The framework is validated to be accurate and effective through numerical experiments, in terms of density and transition probability. It is shown that the second coordinate holds meaningful information for critical transition in various evaluation metrics.

Recently, deep learning-based methods achieved promising performance in nuclei detection and classification applications. However, training deep learning-based methods requires a large amount of pixel-wise annotated data, which is time-consuming and labor-intensive, especially in 3D images. An alternative approach is to adapt weak-annotation methods, such as labeling each nucleus with a point, but this method does not extend from 2D histopathology images (for which it was originally developed) to 3D immunofluorescent images. The reason is that 3D images contain multiple channels (z-axis) for nuclei and different markers separately, which makes training using point annotations difficult. To address this challenge, we propose the Label-efficient Contrastive learning-based (LECL) model to detect and classify various types of nuclei in 3D immunofluorescent images. Previous methods use Maximum Intensity Projection (MIP) to convert immunofluorescent images with multiple slices to 2D images, which can cause signals from different z-stacks to falsely appear associated with each other. To overcome this, we devised an Extended Maximum Intensity Projection (EMIP) approach that addresses issues using MIP. Furthermore, we performed a Supervised Contrastive Learning (SCL) approach for weakly supervised settings. We conducted experiments on cardiovascular datasets and found that our proposed framework is effective and efficient in detecting and classifying various types of nuclei in 3D immunofluorescent images.

For traditional modular software systems, "high cohesion, low coupling" is a recommended setting while it remains so for microservice architectures. However, coupling phenomena commonly exist therein which are caused by cross-service calls and dependencies. In addition, it is noticeable that teams for microservice projects can also suffer from high coupling issues in terms of their cross-service contribution, which can inevitably result in technical debt and high managerial costs. Such organizational coupling needs to be detected and mitigated in time to prevent future losses. Therefore, this paper proposes an automatable approach to evaluate the organizational couple by investigating the microservice ownership and cross-service contribution.

We applied physics-informed neural networks to solve the constitutive relations for nonlinear, path-dependent material behavior. As a result, the trained network not only satisfies all thermodynamic constraints but also instantly provides information about the current material state (i.e., free energy, stress, and the evolution of internal variables) under any given loading scenario without requiring initial data. One advantage of this work is that it bypasses the repetitive Newton iterations needed to solve nonlinear equations in complex material models. Additionally, strategies are provided to reduce the required order of derivative for obtaining the tangent operator. The trained model can be directly used in any finite element package (or other numerical methods) as a user-defined material model. However, challenges remain in the proper definition of collocation points and in integrating several non-equality constraints that become active or non-active simultaneously. We tested this methodology on rate-independent processes such as the classical von Mises plasticity model with a nonlinear hardening law, as well as local damage models for interface cracking behavior with a nonlinear softening law. In order to demonstrate the applicability of the methodology in handling complex path dependency in a three-dimensional (3D) scenario, we tested the approach using the equations governing a damage model for a three-dimensional interface model. Such models are frequently employed for intergranular fracture at grain boundaries. We have observed a perfect agreement between the results obtained through the proposed methodology and those obtained using the classical approach. Furthermore, the proposed approach requires significantly less effort in terms of implementation and computing time compared to the traditional methods.

Distributed averaging is among the most relevant cooperative control problems, with applications in sensor and robotic networks, distributed signal processing, data fusion, and load balancing. Consensus and gossip algorithms have been investigated and successfully deployed in multi-agent systems to perform distributed averaging in synchronous and asynchronous settings. This study proposes a heuristic approach to estimate the convergence rate of averaging algorithms in a distributed manner, relying on the computation and propagation of local graph metrics while entailing simple data elaboration and small message passing. The protocol enables nodes to predict the time (or the number of interactions) needed to estimate the global average with the desired accuracy. Consequently, nodes can make informed decisions on their use of measured and estimated data while gaining awareness of the global structure of the network, as well as their role in it. The study presents relevant applications to outliers identification and performance evaluation in switching topologies.

The growing need for accurate and reliable tracking systems has driven significant progress in sensor fusion and object tracking techniques. In this paper, we design two variational Bayesian trackers that effectively track multiple targets in cluttered environments within a sensor network. We first present a centralised sensor fusion scheme, which involves transmitting sensor data to a fusion center. Then, we develop a distributed version leveraging the average consensus algorithm, which is theoretically equivalent to the centralised sensor fusion tracker and requires only local message passing with neighbouring sensors. In addition, we empirically verify that our proposed distributed variational tracker performs on par with the centralised version with equal tracking accuracy. Simulation results show that our distributed multi-target tracker outperforms the suboptimal distributed sensor fusion strategy that fuses each sensor's posterior based on arithmetic sensor fusion and an average consensus strategy.

Intelligent vehicle anticipation of the movement intentions of other drivers can reduce collisions. Typically, when a human driver of another vehicle (referred to as the target vehicle) engages in specific behaviors such as checking the rearview mirror prior to lane change, a valuable clue is therein provided on the intentions of the target vehicle's driver. Furthermore, the target driver's intentions can be influenced and shaped by their driving environment. For example, if the target vehicle is too close to a leading vehicle, it may renege the lane change decision. On the other hand, a following vehicle in the target lane is too close to the target vehicle could lead to its reversal of the decision to change lanes. Knowledge of such intentions of all vehicles in a traffic stream can help enhance traffic safety. Unfortunately, such information is often captured in the form of images/videos. Utilization of personally identifiable data to train a general model could violate user privacy. Federated Learning (FL) is a promising tool to resolve this conundrum. FL efficiently trains models without exposing the underlying data. This paper introduces a Personalized Federated Learning (PFL) model embedded a long short-term transformer (LSTR) framework. The framework predicts drivers' intentions by leveraging in-vehicle videos (of driver movement, gestures, and expressions) and out-of-vehicle videos (of the vehicle's surroundings - frontal/rear areas). The proposed PFL-LSTR framework is trained and tested through real-world driving data collected from human drivers at Interstate 65 in Indiana. The results suggest that the PFL-LSTR exhibits high adaptability and high precision, and that out-of-vehicle information (particularly, the driver's rear-mirror viewing actions) is important because it helps reduce false positives and thereby enhances the precision of driver intention inference.

In large-scale systems there are fundamental challenges when centralised techniques are used for task allocation. The number of interactions is limited by resource constraints such as on computation, storage, and network communication. We can increase scalability by implementing the system as a distributed task-allocation system, sharing tasks across many agents. However, this also increases the resource cost of communications and synchronisation, and is difficult to scale. In this paper we present four algorithms to solve these problems. The combination of these algorithms enable each agent to improve their task allocation strategy through reinforcement learning, while changing how much they explore the system in response to how optimal they believe their current strategy is, given their past experience. We focus on distributed agent systems where the agents' behaviours are constrained by resource usage limits, limiting agents to local rather than system-wide knowledge. We evaluate these algorithms in a simulated environment where agents are given a task composed of multiple subtasks that must be allocated to other agents with differing capabilities, to then carry out those tasks. We also simulate real-life system effects such as networking instability. Our solution is shown to solve the task allocation problem to 6.7% of the theoretical optimal within the system configurations considered. It provides 5x better performance recovery over no-knowledge retention approaches when system connectivity is impacted, and is tested against systems up to 100 agents with less than a 9% impact on the algorithms' performance.

Vision-based vehicle detection approaches achieve incredible success in recent years with the development of deep convolutional neural network (CNN). However, existing CNN based algorithms suffer from the problem that the convolutional features are scale-sensitive in object detection task but it is common that traffic images and videos contain vehicles with a large variance of scales. In this paper, we delve into the source of scale sensitivity, and reveal two key issues: 1) existing RoI pooling destroys the structure of small scale objects, 2) the large intra-class distance for a large variance of scales exceeds the representation capability of a single network. Based on these findings, we present a scale-insensitive convolutional neural network (SINet) for fast detecting vehicles with a large variance of scales. First, we present a context-aware RoI pooling to maintain the contextual information and original structure of small scale objects. Second, we present a multi-branch decision network to minimize the intra-class distance of features. These lightweight techniques bring zero extra time complexity but prominent detection accuracy improvement. The proposed techniques can be equipped with any deep network architectures and keep them trained end-to-end. Our SINet achieves state-of-the-art performance in terms of accuracy and speed (up to 37 FPS) on the KITTI benchmark and a new highway dataset, which contains a large variance of scales and extremely small objects.

Recent advances in 3D fully convolutional networks (FCN) have made it feasible to produce dense voxel-wise predictions of volumetric images. In this work, we show that a multi-class 3D FCN trained on manually labeled CT scans of several anatomical structures (ranging from the large organs to thin vessels) can achieve competitive segmentation results, while avoiding the need for handcrafting features or training class-specific models. To this end, we propose a two-stage, coarse-to-fine approach that will first use a 3D FCN to roughly define a candidate region, which will then be used as input to a second 3D FCN. This reduces the number of voxels the second FCN has to classify to ~10% and allows it to focus on more detailed segmentation of the organs and vessels. We utilize training and validation sets consisting of 331 clinical CT images and test our models on a completely unseen data collection acquired at a different hospital that includes 150 CT scans, targeting three anatomical organs (liver, spleen, and pancreas). In challenging organs such as the pancreas, our cascaded approach improves the mean Dice score from 68.5 to 82.2%, achieving the highest reported average score on this dataset. We compare with a 2D FCN method on a separate dataset of 240 CT scans with 18 classes and achieve a significantly higher performance in small organs and vessels. Furthermore, we explore fine-tuning our models to different datasets. Our experiments illustrate the promise and robustness of current 3D FCN based semantic segmentation of medical images, achieving state-of-the-art results. Our code and trained models are available for download: //github.com/holgerroth/3Dunet_abdomen_cascade.