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Scarcity of health care resources could result in the unavoidable consequence of rationing. For example, ventilators are often limited in supply, especially during public health emergencies or in resource-constrained health care settings, such as amid the pandemic of COVID-19. Currently, there is no universally accepted standard for health care resource allocation protocols, resulting in different governments prioritizing patients based on various criteria and heuristic-based protocols. In this study, we investigate the use of reinforcement learning for critical care resource allocation policy optimization to fairly and effectively ration resources. We propose a transformer-based deep Q-network to integrate the disease progression of individual patients and the interaction effects among patients during the critical care resource allocation. We aim to improve both fairness of allocation and overall patient outcomes. Our experiments demonstrate that our method significantly reduces excess deaths and achieves a more equitable distribution under different levels of ventilator shortage, when compared to existing severity-based and comorbidity-based methods in use by different governments. Our source code is included in the supplement and will be released on Github upon publication.

Financial stability is a key challenge for individuals living with bipolar disorder (BD). Symptomatic periods in BD are associated with poor financial decision-making, contributing to a negative cycle of worsening symptoms and an increased risk of bankruptcy. There has been an increased focus on designing supportive financial technologies (fintech) to address varying and intermittent needs across different stages of BD. However, little is known about this population's expectations and privacy preferences related to financial data sharing for longitudinal care management. To address this knowledge gap, we have deployed a factorial vignette survey using the Contextual Integrity framework. Our data from individuals with BD (N=480) shows that they are open to share financial data for long term care management. We have also identified significant differences in sharing preferences across age, gender, and diagnostic subtype. We discuss the implications of these findings in designing equitable fintech to support this marginalized community.

Cyber-Physical Systems (CPSs) play a central role in the behavior of a wide range of autonomous physical systems such as medical devices, autonomous vehicles, and smart homes, many of which are safety-critical. CPSs are often specified iteratively as a sequence of models at different levels that can be tested via simulation systems at early stages of their development cycle. One such model is a hybrid automaton; these are used frequently for CPS applications and have the advantage of encapsulating both continuous and discrete CPS behaviors. When testing CPSs, engineers can take advantage of these models to generate test cases that target both types of these behaviors. Moreover, since these models are constructed early in the development process for CPSs, they allow test cases to be generated early in that process for those CPSs, even before simulation models of the CPSs have been designed. One challenge when testing CPSs is that these systems may operate differently even under an identically applied test scenario. In such cases, we cannot employ test oracles that use predetermined deterministic behaviors; instead, test oracles should consider sets of desired behaviors in order to determine whether the CPS has behaved appropriately. In this paper we present a test case generation technique, HYTEST, that generates test cases based on hybrid models, accompanied by appropriate test oracles, for use in testing CPSs early in their development cycle. To evaluate the effectiveness and efficiency of HYTEST, we conducted an empirical study in which we applied the technique to several CPSs and measured its ability to detect faults in those CPSs and the amount of time required to perform the testing process. The results of the study show that HYTEST was able to detect faults more effectively and efficiently than the baseline techniques we compare it to.

Automated Guided Vehicles (AGVs) are widely adopted in various industries due to their efficiency and adaptability. However, safely deploying AGVs in dynamic environments remains a significant challenge. This paper introduces an online trajectory optimization framework, the Fast Safe Rectangular Corridor (FSRC), designed for AGVs in obstacle-rich settings. The primary challenge is efficiently planning trajectories that prioritize safety and collision avoidance. To tackle this challenge, the FSRC algorithm constructs convex regions, represented as rectangular corridors, to address obstacle avoidance constraints within an optimal control problem. This conversion from non-convex to box constraints improves the collision avoidance efficiency and quality. Additionally, the Modified Visibility Graph algorithm speeds up path planning, and a boundary discretization strategy expedites FSRC construction. The framework also includes a dynamic obstacle avoidance strategy for real-time adaptability. Our framework's effectiveness and superiority have been demonstrated in experiments, particularly in computational efficiency (see Fig. \ref{fig:case1} and \ref{fig:case23}). Compared to state-of-the-art frameworks, our trajectory planning framework significantly enhances computational efficiency, ranging from 1 to 2 orders of magnitude (see Table \ref{tab:res}). Notably, the FSRC algorithm outperforms other safe convex corridor-based methods, substantially improving computational efficiency by 1 to 2 orders of magnitude (see Table \ref{tab:FRSC}).

Objective: Neoadjuvant chemotherapy (NACT) is one kind of treatment for advanced stage ovarian cancer patients. However, due to the nature of tumor heterogeneity, the patients' responses to NACT varies significantly among different subgroups. To address this clinical challenge, the purpose of this study is to develop a novel image marker to achieve high accuracy response prediction of the NACT at an early stage. Methods: For this purpose, we first computed a total of 1373 radiomics features to quantify the tumor characteristics, which can be grouped into three categories: geometric, intensity, and texture features. Second, all these features were optimized by principal component analysis algorithm to generate a compact and informative feature cluster. Using this cluster as the input, an SVM based classifier was developed and optimized to create a final marker, indicating the likelihood of the patient being responsive to the NACT treatment. To validate this scheme, a total of 42 ovarian cancer patients were retrospectively collected. A nested leave-one-out cross-validation was adopted for model performance assessment. Results: The results demonstrate that the new method yielded an AUC (area under the ROC [receiver characteristic operation] curve) of 0.745. Meanwhile, the model achieved overall accuracy of 76.2%, positive predictive value of 70%, and negative predictive value of 78.1%. Conclusion: This study provides meaningful information for the development of radiomics based image markers in NACT response prediction.

Achieving success in agricultural activities heavily relies on precise navigation in row crop fields. Recently, segmentation-based navigation has emerged as a reliable technique when GPS-based localization is unavailable or higher accuracy is needed due to vegetation or unfavorable weather conditions. It also comes in handy when plants are growing rapidly and require an online adaptation of the navigation algorithm. This work applies a segmentation-based visual agnostic navigation algorithm to lavender fields, considering both simulation and real-world scenarios. The effectiveness of this approach is validated through a wide set of experimental tests, which show the capability of the proposed solution to generalize over different scenarios and provide highly-reliable results.

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer in which the tumor-vascular involvement greatly affects the resectability and, thus, overall survival of patients. However, current prognostic prediction methods fail to explicitly and accurately investigate relationships between the tumor and nearby important vessels. This paper proposes a novel learnable neural distance that describes the precise relationship between the tumor and vessels in CT images of different patients, adopting it as a major feature for prognosis prediction. Besides, different from existing models that used CNNs or LSTMs to exploit tumor enhancement patterns on dynamic contrast-enhanced CT imaging, we improved the extraction of dynamic tumor-related texture features in multi-phase contrast-enhanced CT by fusing local and global features using CNN and transformer modules, further enhancing the features extracted across multi-phase CT images. We extensively evaluated and compared the proposed method with existing methods in the multi-center (n=4) dataset with 1,070 patients with PDAC, and statistical analysis confirmed its clinical effectiveness in the external test set consisting of three centers. The developed risk marker was the strongest predictor of overall survival among preoperative factors and it has the potential to be combined with established clinical factors to select patients at higher risk who might benefit from neoadjuvant therapy.

In global healthcare, respiratory diseases are a leading cause of mortality, underscoring the need for rapid and accurate diagnostics. To advance rapid screening techniques via auscultation, our research focuses on employing one of the largest publicly available medical database of respiratory sounds to train multiple machine learning models able to classify different health conditions. Our method combines Empirical Mode Decomposition (EMD) and spectral analysis to extract physiologically relevant biosignals from acoustic data, closely tied to cardiovascular and respiratory patterns, making our approach apart in its departure from conventional audio feature extraction practices. We use Power Spectral Density analysis and filtering techniques to select Intrinsic Mode Functions (IMFs) strongly correlated with underlying physiological phenomena. These biosignals undergo a comprehensive feature extraction process for predictive modeling. Initially, we deploy a binary classification model that demonstrates a balanced accuracy of 87% in distinguishing between healthy and diseased individuals. Subsequently, we employ a six-class classification model that achieves a balanced accuracy of 72% in diagnosing specific respiratory conditions like pneumonia and chronic obstructive pulmonary disease (COPD). For the first time, we also introduce regression models that estimate age and body mass index (BMI) based solely on acoustic data, as well as a model for gender classification. Our findings underscore the potential of this approach to significantly enhance assistive and remote diagnostic capabilities.

Knowledge enhanced pre-trained language models (K-PLMs) are shown to be effective for many public tasks in the literature but few of them have been successfully applied in practice. To address this problem, we propose K-AID, a systematic approach that includes a low-cost knowledge acquisition process for acquiring domain knowledge, an effective knowledge infusion module for improving model performance, and a knowledge distillation component for reducing the model size and deploying K-PLMs on resource-restricted devices (e.g., CPU) for real-world application. Importantly, instead of capturing entity knowledge like the majority of existing K-PLMs, our approach captures relational knowledge, which contributes to better-improving sentence-level text classification and text matching tasks that play a key role in question answering (QA). We conducted a set of experiments on five text classification tasks and three text matching tasks from three domains, namely E-commerce, Government, and Film&TV, and performed online A/B tests in E-commerce. Experimental results show that our approach is able to achieve substantial improvement on sentence-level question answering tasks and bring beneficial business value in industrial settings.

We study the problem of named entity recognition (NER) from electronic medical records, which is one of the most fundamental and critical problems for medical text mining. Medical records which are written by clinicians from different specialties usually contain quite different terminologies and writing styles. The difference of specialties and the cost of human annotation makes it particularly difficult to train a universal medical NER system. In this paper, we propose a label-aware double transfer learning framework (La-DTL) for cross-specialty NER, so that a medical NER system designed for one specialty could be conveniently applied to another one with minimal annotation efforts. The transferability is guaranteed by two components: (i) we propose label-aware MMD for feature representation transfer, and (ii) we perform parameter transfer with a theoretical upper bound which is also label aware. We conduct extensive experiments on 12 cross-specialty NER tasks. The experimental results demonstrate that La-DTL provides consistent accuracy improvement over strong baselines. Besides, the promising experimental results on non-medical NER scenarios indicate that La-DTL is potential to be seamlessly adapted to a wide range of NER tasks.