亚洲男人的天堂2018av,欧美草比,久久久久久免费视频精选,国色天香在线看免费,久久久久亚洲av成人片仓井空

Factors contributing to social inequalities are also associated with negative mental health outcomes leading to disparities in mental well-being. We propose a Bayesian hierarchical model which can evaluate the impact of policies on population well-being, accounting for spatial/temporal dependencies. Building on an interrupted time series framework, our approach can evaluate how different profiles of individuals are affected in different ways, whilst accounting for their uncertainty. We apply the framework to assess the impact of the United Kingdoms welfare reform, which took place throughout the 2010s, on mental well-being using data from the UK Household Longitudinal Study. The additional depth of knowledge is essential for effective evaluation of current policy and implementation of future policy.

Clinical trials often involve the assessment of multiple endpoints to comprehensively evaluate the efficacy and safety of interventions. In the work, we consider a global nonparametric testing procedure based on multivariate rank for the analysis of multiple endpoints in clinical trials. Unlike other existing approaches that rely on pairwise comparisons for each individual endpoint, the proposed method directly incorporates the multivariate ranks of the observations. By considering the joint ranking of all endpoints, the proposed approach provides robustness against diverse data distributions and censoring mechanisms commonly encountered in clinical trials. Through extensive simulations, we demonstrate the superior performance of the multivariate rank-based approach in controlling type I error and achieving higher power compared to existing rank-based methods. The simulations illustrate the advantages of leveraging multivariate ranks and highlight the robustness of the approach in various settings. The proposed method offers an effective tool for the analysis of multiple endpoints in clinical trials, enhancing the reliability and efficiency of outcome evaluations.

Counterfactual inference considers a hypothetical intervention in a parallel world that shares some evidence with the factual world. If the evidence specifies a conditional distribution on a manifold, counterfactuals may be analytically intractable. We present an algorithm for simulating values from a counterfactual distribution where conditions can be set on both discrete and continuous variables. We show that the proposed algorithm can be presented as a particle filter leading to asymptotically valid inference. The algorithm is applied to fairness analysis in credit scoring.

Context. Algorithmic racism is the term used to describe the behavior of technological solutions that constrains users based on their ethnicity. Lately, various data-driven software systems have been reported to discriminate against Black people, either for the use of biased data sets or due to the prejudice propagated by software professionals in their code. As a result, Black people are experiencing disadvantages in accessing technology-based services, such as housing, banking, and law enforcement. Goal. This study aims to explore algorithmic racism from the perspective of software professionals. Method. A survey questionnaire was applied to explore the understanding of software practitioners on algorithmic racism, and data analysis was conducted using descriptive statistics and coding techniques. Results. We obtained answers from a sample of 73 software professionals discussing their understanding and perspectives on algorithmic racism in software development. Our results demonstrate that the effects of algorithmic racism are well-known among practitioners. However, there is no consensus on how the problem can be effectively addressed in software engineering. In this paper, some solutions to the problem are proposed based on the professionals' narratives. Conclusion. Combining technical and social strategies, including training on structural racism for software professionals, is the most promising way to address the algorithmic racism problem and its effects on the software solutions delivered to our society.

With some regularity conditions maximum likelihood estimators (MLEs) always produce asymptotically optimal (in the sense of consistency, efficiency, sufficiency, and unbiasedness) estimators. But in general, the MLEs lead to non-robust statistical inference, for example, pricing models and risk measures. Actuarial claim severity is continuous, right-skewed, and frequently heavy-tailed. The data sets that such models are usually fitted to contain outliers that are difficult to identify and separate from genuine data. Moreover, due to commonly used actuarial "loss control strategies" in financial and insurance industries, the random variables we observe and wish to model are affected by truncation (due to deductibles), censoring (due to policy limits), scaling (due to coinsurance proportions) and other transformations. To alleviate the lack of robustness of MLE-based inference in risk modeling, here in this paper, we propose and develop a new method of estimation - method of truncated moments (MTuM) and generalize it for different scenarios of loss control mechanism. Various asymptotic properties of those estimates are established by using central limit theory. New connections between different estimators are found. A comparative study of newly-designed methods with the corresponding MLEs is performed. Detail investigation has been done for a single parameter Pareto loss model including a simulation study.

An N-of-1 trial is a multiple crossover trial conducted in a single individual to provide evidence to directly inform personalized treatment decisions. Advancements in wearable devices greatly improved the feasibility of adopting these trials to identify optimal individual treatment plans, particularly when treatments differ among individuals and responses are highly heterogeneous. Our work was motivated by the I-STOP-AFib Study, which examined the impact of different triggers on atrial fibrillation (AF) occurrence. We described a causal framework for 'N-of-1' trial using potential treatment selection paths and potential outcome paths. Two estimands of individual causal effect were defined:(a) the effect of continuous exposure, and (b) the effect of an individual observed behavior. We addressed three challenges: (a) imperfect compliance to the randomized treatment assignment; (b) binary treatments and binary outcomes which led to the 'non-collapsibility' issue of estimating odds ratios; and (c) serial inference in the longitudinal observations. We adopted the Bayesian IV approach where the study randomization was the IV as it impacted the choice of exposure of a subject but not directly the outcome. Estimations were through a system of two parametric Bayesian models to estimate the individual causal effect. Our model got around the non-collapsibility and non-consistency by modeling the confounding mechanism through latent structural models and by inferring with Bayesian posterior of functionals. Autocorrelation present in the repeated measurements was also accounted for. The simulation study showed our method largely reduced bias and greatly improved the coverage of the estimated causal effect, compared to existing methods (ITT, PP, and AT). We applied the method to I-STOP-AFib Study to estimate the individual effect of alcohol on AF occurrence.

Digital twin (DT), refers to a promising technique to digitally and accurately represent actual physical entities. One typical advantage of DT is that it can be used to not only virtually replicate a system's detailed operations but also analyze the current condition, predict future behaviour, and refine the control optimization. Although DT has been widely implemented in various fields, such as smart manufacturing and transportation, its conventional paradigm is limited to embody non-living entities, e.g., robots and vehicles. When adopted in human-centric systems, a novel concept, called human digital twin (HDT) has thus been proposed. Particularly, HDT allows in silico representation of individual human body with the ability to dynamically reflect molecular status, physiological status, emotional and psychological status, as well as lifestyle evolutions. These prompt the expected application of HDT in personalized healthcare (PH), which can facilitate remote monitoring, diagnosis, prescription, surgery and rehabilitation. However, despite the large potential, HDT faces substantial research challenges in different aspects, and becomes an increasingly popular topic recently. In this survey, with a specific focus on the networking architecture and key technologies for HDT in PH applications, we first discuss the differences between HDT and conventional DTs, followed by the universal framework and essential functions of HDT. We then analyze its design requirements and challenges in PH applications. After that, we provide an overview of the networking architecture of HDT, including data acquisition layer, data communication layer, computation layer, data management layer and data analysis and decision making layer. Besides reviewing the key technologies for implementing such networking architecture in detail, we conclude this survey by presenting future research directions of HDT.

Prediction models have been widely adopted as the basis for decision-making in domains as diverse as employment, education, lending, and health. Yet, few real world problems readily present themselves as precisely formulated prediction tasks. In particular, there are often many reasonable target variable options. Prior work has argued that this is an important and sometimes underappreciated choice, and has also shown that target choice can have a significant impact on the fairness of the resulting model. However, the existing literature does not offer a formal framework for characterizing the extent to which target choice matters in a particular task. Our work fills this gap by drawing connections between the problem of target choice and recent work on predictive multiplicity. Specifically, we introduce a conceptual and computational framework for assessing how the choice of target affects individuals' outcomes and selection rate disparities across groups. We call this multi-target multiplicity. Along the way, we refine the study of single-target multiplicity by introducing notions of multiplicity that respect resource constraints -- a feature of many real-world tasks that is not captured by existing notions of predictive multiplicity. We apply our methods on a healthcare dataset, and show that the level of multiplicity that stems from target variable choice can be greater than that stemming from nearly-optimal models of a single target.

Accurate navigation is essential for autonomous robots and vehicles. In recent years, the integration of the Global Navigation Satellite System (GNSS), Inertial Navigation System (INS), and camera has garnered considerable attention due to its robustness and high accuracy in diverse environments. In such systems, fully utilizing the role of GNSS is cumbersome because of the diverse choices of formulations, error models, satellite constellations, signal frequencies, and service types, which lead to different precision, robustness, and usage dependencies. To clarify the capacity of GNSS algorithms and accelerate the development efficiency of employing GNSS in multi-sensor fusion algorithms, we open source the GNSS/INS/Camera Integration Library (GICI-LIB), together with detailed documentation and a comprehensive land vehicle dataset. A factor graph optimization-based multi-sensor fusion framework is established, which combines almost all GNSS measurement error sources by fully considering temporal and spatial correlations between measurements. The graph structure is designed for flexibility, making it easy to form any kind of integration algorithm. For illustration, four Real-Time Kinematic (RTK)-based algorithms from GICI-LIB are evaluated using our dataset. Results confirm the potential of the GICI system to provide continuous precise navigation solutions in a wide spectrum of urban environments.

Effective multi-robot teams require the ability to move to goals in complex environments in order to address real-world applications such as search and rescue. Multi-robot teams should be able to operate in a completely decentralized manner, with individual robot team members being capable of acting without explicit communication between neighbors. In this paper, we propose a novel game theoretic model that enables decentralized and communication-free navigation to a goal position. Robots each play their own distributed game by estimating the behavior of their local teammates in order to identify behaviors that move them in the direction of the goal, while also avoiding obstacles and maintaining team cohesion without collisions. We prove theoretically that generated actions approach a Nash equilibrium, which also corresponds to an optimal strategy identified for each robot. We show through extensive simulations that our approach enables decentralized and communication-free navigation by a multi-robot system to a goal position, and is able to avoid obstacles and collisions, maintain connectivity, and respond robustly to sensor noise.