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In the study of cancer evolution and therapeutic strategies, scientific evidence shows that a key dynamics lies in the tumor-environment interaction. In particular, oxygen concentration plays a central role in the determination of the phenotypic heterogeneity of cancer cell populations, whose qualitative and geometric characteristics are predominant factors in the occurrence of relapses and failure of eradication. We propose a mathematical model able to describe the eco-evolutionary spatial dynamics of tumour cells in their adaptation to hypoxic microenvironments. As a main novelty with respect to the existing literature, we combine a phenotypic indicator reflecting the experimentally-observed metabolic trade-off between the hypoxia-resistance ability and the proliferative potential with a 2d geometric domain, without the constraint of radial symmetry. The model is settled in the mathematical framework of phenotype-structured population dynamics and it is formulated in terms of systems of coupled non-linear integro-differential equations. The computational outcomes demonstrate that hypoxia-induced selection results in a geometric characterization of phenotypic-defined tumour niches that impact on tumour aggressiveness and invasive ability. Furthermore, results show how the knowledge of environmental characteristics provides a predictive advantage on tumour mass development in terms of size, shape, and composition.

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Experimental data can aid in gaining insights about a system operation, as well as determining critical aspects of a modelling or simulation process. In this paper, we analyze the data acquired from an extensive experimentation process in a serverless Function as a Service system (based on the open source Apache Openwhisk) that has been deployed across 3 available cloud/edge locations with different system setups. Thus, they can be used to model distribution of functions through multi-location aware scheduling mechanisms. The experiments include different traffic arrival rates, different setups for the FaaS system, as well as different configurations for the hardware and platform used. We analyse the acquired data for the three FaaS system setups and discuss their differences presenting interesting conclusions with relation to transient effects of the system, such as the effect on wait and execution time. We also demonstrate interesting trade-offs with relation to system setup and indicate a number of factors that can affect system performance and should be taken under consideration in modelling attempts of such systems.

A growing number of central authorities use assignment mechanisms to allocate students to schools in a way that reflects student preferences and school priorities. However, most real-world mechanisms give students an incentive to be strategic and misreport their preferences. In this paper, we provide an identification approach for causal effects of school assignment on future outcomes that accounts for strategic misreporting. Misreporting may invalidate existing point-identification approaches, and we derive sharp bounds for causal effects that are robust to strategic behavior. Our approach applies to any mechanism as long as there exist placement scores and cutoffs that characterize that mechanism's allocation rule. We use data from a deferred acceptance mechanism that assigns students to more than 1,000 university-major combinations in Chile. Students behave strategically because the mechanism in Chile constrains the number of majors that students submit in their preferences to eight options. Our methodology takes that into account and partially identifies the effect of changes in school assignment on various graduation outcomes.

We study the convex hulls of reachable sets of nonlinear systems with bounded disturbances. Reachable sets play a critical role in control, but remain notoriously challenging to compute, and existing over-approximation tools tend to be conservative or computationally expensive. In this work, we exactly characterize the convex hulls of reachable sets as the convex hulls of solutions of an ordinary differential equation from all possible initial values of the disturbances. This finite-dimensional characterization unlocks a fast sampling-based method to accurately over-approximate reachable sets. We give applications to neural feedback loop analysis and robust model predictive control.

We prove that functions over the reals computable in polynomial time can be characterised using discrete ordinary differential equations (ODE), also known as finite differences. We also provide a characterisation of functions computable in polynomial space over the reals. In particular, this covers space complexity, while existing characterisations were only able to cover time complexity, and were restricted to functions over the integers. We prove furthermore that no artificial sign or test function is needed even for time complexity. At a technical level, this is obtained by proving that Turing machines can be simulated with analytic discrete ordinary differential equations. We believe this result opens the way to many applications, as it opens the possibility of programming with ODEs, with an underlying well-understood time and space complexity.

Stratification in both the design and analysis of randomized clinical trials is common. Despite features in automated randomization systems to re-confirm the stratifying variables, incorrect values of these variables may be entered. These errors are often detected during subsequent data collection and verification. Questions remain about whether to use the mis-reported initial stratification or the corrected values in subsequent analyses. It is shown that the likelihood function resulting from the design of randomized clinical trials supports the use of the corrected values. New definitions are proposed that characterize misclassification errors as `ignorable' and `non-ignorable'. Ignorable errors may depend on the correct strata and any other modeled baseline covariates, but they are otherwise unrelated to potential treatment outcomes. Data management review suggests most misclassification errors are arbitrarily produced by distracted investigators, so they are ignorable or at most weakly dependent on measured and unmeasured baseline covariates. Ignorable misclassification errors may produce a small increase in standard errors, but other properties of the planned analyses are unchanged (e.g., unbiasedness, confidence interval coverage). It is shown that unbiased linear estimation in the absence of misclassification errors remains unbiased when there are non-ignorable misclassification errors, and the corresponding confidence intervals based on the corrected strata values are conservative.

Recently, there has been great interest in estimating the conditional average treatment effect using flexible machine learning methods. However, in practice, investigators often have working hypotheses about effect heterogeneity across pre-defined subgroups of study units, which we call the groupwise approach. The paper compares two modern ways to estimate groupwise treatment effects, a nonparametric approach and a semiparametric approach, with the goal of better informing practice. Specifically, we compare (a) the underlying assumptions, (b) efficiency and adaption to the underlying data generating models, and (c) a way to combine the two approaches. We also discuss how to test a key assumption concerning the semiparametric estimator and to obtain cluster-robust standard errors if study units in the same subgroups are correlated. We demonstrate our findings by conducting simulation studies and reanalyzing the Early Childhood Longitudinal Study.

The optimization of open-loop shallow geothermal systems, which includes both design and operational aspects, is an important research area aimed at improving their efficiency and sustainability and the effective management of groundwater as a shallow geothermal resource. This paper investigates various approaches to address optimization problems arising from such research questions. The identified optimization approaches are thoroughly analyzed based on criteria such as computational efficiency and applicability. Moreover, a novel classification scheme is introduced that categorizes the approaches according to the type of groundwater simulation model (numerical or simplified) and the optimization algorithm used (gradient-based or derivative-free). Finally, a comprehensive review of existing approaches is provided, highlighting their strengths and limitations and offering recommendations for both the use of existing approaches and the development of new ones in this field.

Many scientific problems require to process data in the form of geometric graphs. Unlike generic graph data, geometric graphs exhibit symmetries of translations, rotations, and/or reflections. Researchers have leveraged such inductive bias and developed geometrically equivariant Graph Neural Networks (GNNs) to better characterize the geometry and topology of geometric graphs. Despite fruitful achievements, it still lacks a survey to depict how equivariant GNNs are progressed, which in turn hinders the further development of equivariant GNNs. To this end, based on the necessary but concise mathematical preliminaries, we analyze and classify existing methods into three groups regarding how the message passing and aggregation in GNNs are represented. We also summarize the benchmarks as well as the related datasets to facilitate later researches for methodology development and experimental evaluation. The prospect for future potential directions is also provided.

Australia is a leading AI nation with strong allies and partnerships. Australia has prioritised robotics, AI, and autonomous systems to develop sovereign capability for the military. Australia commits to Article 36 reviews of all new means and methods of warfare to ensure weapons and weapons systems are operated within acceptable systems of control. Additionally, Australia has undergone significant reviews of the risks of AI to human rights and within intelligence organisations and has committed to producing ethics guidelines and frameworks in Security and Defence. Australia is committed to OECD's values-based principles for the responsible stewardship of trustworthy AI as well as adopting a set of National AI ethics principles. While Australia has not adopted an AI governance framework specifically for Defence; Defence Science has published 'A Method for Ethical AI in Defence' (MEAID) technical report which includes a framework and pragmatic tools for managing ethical and legal risks for military applications of AI.

Federated learning (FL) is an emerging, privacy-preserving machine learning paradigm, drawing tremendous attention in both academia and industry. A unique characteristic of FL is heterogeneity, which resides in the various hardware specifications and dynamic states across the participating devices. Theoretically, heterogeneity can exert a huge influence on the FL training process, e.g., causing a device unavailable for training or unable to upload its model updates. Unfortunately, these impacts have never been systematically studied and quantified in existing FL literature. In this paper, we carry out the first empirical study to characterize the impacts of heterogeneity in FL. We collect large-scale data from 136k smartphones that can faithfully reflect heterogeneity in real-world settings. We also build a heterogeneity-aware FL platform that complies with the standard FL protocol but with heterogeneity in consideration. Based on the data and the platform, we conduct extensive experiments to compare the performance of state-of-the-art FL algorithms under heterogeneity-aware and heterogeneity-unaware settings. Results show that heterogeneity causes non-trivial performance degradation in FL, including up to 9.2% accuracy drop, 2.32x lengthened training time, and undermined fairness. Furthermore, we analyze potential impact factors and find that device failure and participant bias are two potential factors for performance degradation. Our study provides insightful implications for FL practitioners. On the one hand, our findings suggest that FL algorithm designers consider necessary heterogeneity during the evaluation. On the other hand, our findings urge system providers to design specific mechanisms to mitigate the impacts of heterogeneity.

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