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Objective: Function is increasingly recognized as an important indicator of whole-person health. This study evaluates the ability of publicly available large language models (LLMs) to accurately identify the presence of functioning information from clinical notes. We explore various strategies to improve the performance on this task. Materials and Methods: We collect a balanced binary classification dataset of 1000 sentences from the Mobility NER dataset, which was curated from n2c2 clinical notes. For evaluation, we construct zero-shot and few-shot prompts to query the LLMs whether a given sentence contains mobility functioning information. Two sampling techniques, random sampling and k-nearest neighbor (kNN)-based sampling, are used to select the few-shot examples. Furthermore, we apply a parameter-efficient prompt-based fine-tuning method to the LLMs and evaluate their performance under various training settings. Results: Flan-T5-xxl outperforms all other models in both zero-shot and few-shot settings, achieving a F1 score of 0.865 with a single demonstrative example selected by kNN sampling. In prompt-based fine-tuning experiments, this foundation model also demonstrates superior performance across all low-resource settings, particularly achieving an impressive F1 score of 0.922 using the full training dataset. The smaller model, Flan-T5-xl, requires fine-tuning with only 2.3M additional parameters to achieve comparable performance to the fully fine-tuned Gatortron-base model, both surpassing 0.9 F1 score. Conclusion: Open-source instruction-tuned LLMs demonstrate impressive in-context learning capability in the mobility functioning classification task. The performance of these models can be further improved by continuing fine-tuning on a task-specific dataset.

We describe and analyze a quasi-Trefftz DG method for solving boundary value problems for the homogeneous diffusion-advection-reaction equation with piecewise-smooth coefficients. Trefftz schemes are high-order Galerkin methods whose discrete functions are elementwise exact solutions of the underlying PDE. Trefftz basis functions can be computed for many PDEs that are linear, homogeneous and with piecewise-constant coefficients. However, if the equation has varying coefficients, in general, exact solutions are unavailable, hence the construction of discrete Trefftz spaces is impossible. Quasi-Trefftz methods have been introduced to overcome this limitation, relying on discrete spaces of functions that are elementwise "approximate solutions" of the PDE. A space-time quasi-Trefftz DG method for the acoustic wave equation with smoothly varying coefficients has recently been studied; since it has shown excellent results, we propose a related method that can be applied to second-order elliptic equations. The DG weak formulation is derived using an interior penalty parameter and the upwind numerical fluxes. We choose polynomial quasi-Trefftz basis functions, whose coefficients can be computed with a simple algorithm based on the Taylor expansion of the PDE's coefficients. The main advantage of Trefftz and quasi-Trefftz schemes over more classical ones is the higher accuracy for comparable numbers of degrees of freedom. We prove that the dimension of the quasi-Trefftz space is smaller than the dimension of the full polynomial space of the same degree and that yields the same optimal convergence rates. The quasi-Trefftz DG method is well-posed, consistent and stable and we prove its high-order convergence. We present some numerical experiments in two dimensions that show excellent properties in terms of approximation and convergence rate.

With the increasing demand of intelligent systems capable of operating in different contexts (e.g. users on the move) the correct interpretation of the user-need by such systems has become crucial to give consistent answers to the user questions. The most effective applications addressing such task are in the fields of natural language processing and semantic expansion of terms. These techniques are aimed at estimating the goal of an input query reformulating it as an intent, commonly relying on textual resources built exploiting different semantic relations like \emph{synonymy}, \emph{antonymy} and many others. The aim of this paper is to generate such resources using the labels of a given taxonomy as source of information. The obtained resources are integrated into a plain classifier for reformulating a set of input queries as intents and tracking the effect of each relation, in order to quantify the impact of each semantic relation on the classification. As an extension to this, the best tradeoff between improvement and noise introduction when combining such relations is evaluated. The assessment is made generating the resources and their combinations and using them for tuning the classifier which is used to reformulate the user questions as labels. The evaluation employs a wide and varied taxonomy as a use-case, exploiting its labels as basis for the semantic expansion and producing several corpora with the purpose of enhancing the pseudo-queries estimation.

The recent success of neural networks in natural language processing has drawn renewed attention to learning sequence-to-sequence (seq2seq) tasks. While there exists a rich literature that studies classification and regression tasks using solvable models of neural networks, seq2seq tasks have not yet been studied from this perspective. Here, we propose a simple model for a seq2seq task that has the advantage of providing explicit control over the degree of memory, or non-Markovianity, in the sequences -- the stochastic switching-Ornstein-Uhlenbeck (SSOU) model. We introduce a measure of non-Markovianity to quantify the amount of memory in the sequences. For a minimal auto-regressive (AR) learning model trained on this task, we identify two learning regimes corresponding to distinct phases in the stationary state of the SSOU process. These phases emerge from the interplay between two different time scales that govern the sequence statistics. Moreover, we observe that while increasing the integration window of the AR model always improves performance, albeit with diminishing returns, increasing the non-Markovianity of the input sequences can improve or degrade its performance. Finally, we perform experiments with recurrent and convolutional neural networks that show that our observations carry over to more complicated neural network architectures.

The lack of an available emotion pathology database is one of the key obstacles in studying the emotion expression status of patients with dysarthria. The first Chinese multimodal emotional pathological speech database containing multi-perspective information is constructed in this paper. It includes 29 controls and 39 patients with different degrees of motor dysarthria, expressing happy, sad, angry and neutral emotions. All emotional speech was labeled for intelligibility, types and discrete dimensional emotions by developed WeChat mini-program. The subjective analysis justifies from emotion discrimination accuracy, speech intelligibility, valence-arousal spatial distribution, and correlation between SCL-90 and disease severity. The automatic recognition tested on speech and glottal data, with average accuracy of 78% for controls and 60% for patients in audio, while 51% for controls and 38% for patients in glottal data, indicating an influence of the disease on emotional expression.

We propose reinforcement learning to control the dynamical self-assembly of the dodecagonal quasicrystal (DDQC) from patchy particles. The patchy particles have anisotropic interactions with other particles and form DDQC. However, their structures at steady states are significantly influenced by the kinetic pathways of their structural formation. We estimate the best policy of temperature control trained by the Q-learning method and demonstrate that we can generate DDQC with few defects using the estimated policy. The temperature schedule obtained by reinforcement learning can reproduce the desired structure more efficiently than the conventional pre-fixed temperature schedule, such as annealing. To clarify the success of the learning, we also analyse a simple model describing the kinetics of structural changes through the motion in a triple-well potential. We have found that reinforcement learning autonomously discovers the critical temperature at which structural fluctuations enhance the chance of forming a globally stable state. The estimated policy guides the system toward the critical temperature to assist the formation of DDQC.

In the study of the brain, there is a hypothesis that sparse coding is realized in information representation of external stimuli, which is experimentally confirmed for visual stimulus recently. However, unlike the specific functional region in the brain, sparse coding in information processing in the whole brain has not been clarified sufficiently. In this study, we investigate the validity of sparse coding in the whole human brain by applying various matrix factorization methods to functional magnetic resonance imaging data of neural activities in the whole human brain. The result suggests sparse coding hypothesis in information representation in the whole human brain, because extracted features from sparse MF method, SparsePCA or MOD under high sparsity setting, or approximate sparse MF method, FastICA, can classify external visual stimuli more accurately than non-sparse MF method or sparse MF method under low sparsity setting.

Traffic accidents frequently lead to fatal injuries, contributing to over 50 million deaths until 2023. To mitigate driving hazards and ensure personal safety, it is crucial to assist vehicles in anticipating important objects during travel. Previous research on important object detection primarily assessed the importance of individual participants, treating them as independent entities and frequently overlooking the connections between these participants. Unfortunately, this approach has proven less effective in detecting important objects in complex scenarios. In response, we introduce Driving scene Relationship self-Understanding transformer (DRUformer), designed to enhance the important object detection task. The DRUformer is a transformer-based multi-modal important object detection model that takes into account the relationships between all the participants in the driving scenario. Recognizing that driving intention also significantly affects the detection of important objects during driving, we have incorporated a module for embedding driving intention. To assess the performance of our approach, we conducted a comparative experiment on the DRAMA dataset, pitting our model against other state-of-the-art (SOTA) models. The results demonstrated a noteworthy 16.2\% improvement in mIoU and a substantial 12.3\% boost in ACC compared to SOTA methods. Furthermore, we conducted a qualitative analysis of our model's ability to detect important objects across different road scenarios and classes, highlighting its effectiveness in diverse contexts. Finally, we conducted various ablation studies to assess the efficiency of the proposed modules in our DRUformer model.

Breast cancer remains a global challenge, causing over 1 million deaths globally in 2018. To achieve earlier breast cancer detection, screening x-ray mammography is recommended by health organizations worldwide and has been estimated to decrease breast cancer mortality by 20-40%. Nevertheless, significant false positive and false negative rates, as well as high interpretation costs, leave opportunities for improving quality and access. To address these limitations, there has been much recent interest in applying deep learning to mammography; however, obtaining large amounts of annotated data poses a challenge for training deep learning models for this purpose, as does ensuring generalization beyond the populations represented in the training dataset. Here, we present an annotation-efficient deep learning approach that 1) achieves state-of-the-art performance in mammogram classification, 2) successfully extends to digital breast tomosynthesis (DBT; "3D mammography"), 3) detects cancers in clinically-negative prior mammograms of cancer patients, 4) generalizes well to a population with low screening rates, and 5) outperforms five-out-of-five full-time breast imaging specialists by improving absolute sensitivity by an average of 14%. Our results demonstrate promise towards software that can improve the accuracy of and access to screening mammography worldwide.