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Torsades de pointes (TdP) is an irregular heart rhythm characterized by faster beat rates and potentially could lead to sudden cardiac death. Much effort has been invested in understanding the drug-induced TdP in preclinical studies. However, a comprehensive statistical learning framework that can accurately predict the drug-induced TdP risk from preclinical data is still lacking. We proposed ordinal logistic regression and ordinal random forest models to predict low-, intermediate-, and high-risk drugs based on datasets generated from two experimental protocols. Leave-one-drug-out cross-validation, stratified bootstrap, and permutation predictor importance were applied to estimate and interpret the model performance under uncertainty. The potential outlier drugs identified by our models are consistent with their descriptions in the literature. Our method is accurate, interpretable, and thus useable as supplemental evidence in the drug safety assessment.

Reminiscence therapy is an inexpensive non-pharmacological therapy commonly used due to its therapeutic value for PwD, as it can be used to promote independence, positive moods and behavior, and improve their quality of life. Caregivers are one of the main pillars in the adoption of digital technologies for reminiscence therapy, as they are responsible for its administration. Despite their comprehensive understanding of the needs and difficulties associated with the therapy, their perspective has not been fully taken into account in the development of existing technological solutions. To inform the design of technological solutions within dementia care, we followed a user-centered design approach through worldwide surveys, follow-up semi-structured interviews, and focus groups. Seven hundred and seven informal and 52 formal caregivers participated in our study. Our findings show that technological solutions must provide mechanisms to carry out the therapy in a simple way, reducing the amount of work for caregivers when preparing and conducting therapy sessions. They should also diversify and personalize the current session (and following ones) based on both the biographical information of the PwD and their emotional reactions. This is particularly important since the PwD often become agitated, aggressive or angry, and caregivers might not know how to properly deal with this situation (in particular, the informal ones). Additionally, formal caregivers need an easy way to manage information of the different PwD they take care of, and consult the history of sessions performed (in particular, to identify images that triggered negative emotional reactions, and consult any notes taken about them). As a result, we present a list of validated functional requirements gathered for the PwD and both formal and informal caregivers, as well as the corresponding expected primary and secondary outcomes.

The Mat{\'e}rn family of covariance functions has played a central role in spatial statistics for decades, being a flexible parametric class with one parameter determining the smoothness of the paths of the underlying spatial field. This paper proposes a new family of spatial covariance functions, which stems from a reparameterization of the generalized Wendland family. As for the Mat{\'e}rn case, the new class allows for a continuous parameterization of the smoothness of the underlying Gaussian random field, being additionally compactly supported. More importantly, we show that the proposed covariance family generalizes the Mat{\'e}rn model which is attained as a special limit case. The practical implication of our theoretical results questions the effective flexibility of the Mat{\'e}rn covariance from modeling and computational viewpoints. Our numerical experiments elucidate the speed of convergence of the proposed model to the Mat{\'e}rn model. We also inspect the level of sparseness of the associated (inverse) covariance matrix and the asymptotic distribution of the maximum likelihood estimator under increasing and fixed domain asymptotics. The effectiveness of our proposal is illustrated by analyzing a georeferenced dataset on maximum temperatures over the southeastern United States, and performing a re-analysis of a large spatial point referenced dataset of yearly total precipitation anomalies

Extracting spatial-temporal knowledge from data is useful in many applications. It is important that the obtained knowledge is human-interpretable and amenable to formal analysis. In this paper, we propose a method that trains neural networks to learn spatial-temporal properties in the form of weighted graph-based signal temporal logic (wGSTL) formulas. For learning wGSTL formulas, we introduce a flexible wGSTL formula structure in which the user's preference can be applied in the inferred wGSTL formulas. In the proposed framework, each neuron of the neural networks corresponds to a subformula in a flexible wGSTL formula structure. We initially train a neural network to learn the wGSTL operators and then train a second neural network to learn the parameters in a flexible wGSTL formula structure. We use a COVID-19 dataset and a rain prediction dataset to evaluate the performance of the proposed framework and algorithms. We compare the performance of the proposed framework with three baseline classification methods including K-nearest neighbors, decision trees, support vector machine, and artificial neural networks. The classification accuracy obtained by the proposed framework is comparable with the baseline classification methods.

Spectral clustering has been one of the widely used methods for community detection in networks. However, large-scale networks bring computational challenges to the eigenvalue decomposition therein. In this paper, we study the spectral clustering using randomized sketching algorithms from a statistical perspective, where we typically assume the network data are generated from a stochastic block model that is not necessarily of full rank. To do this, we first use the recently developed sketching algorithms to obtain two randomized spectral clustering algorithms, namely, the random projection-based and the random sampling-based spectral clustering. Then we study the theoretical bounds of the resulting algorithms in terms of the approximation error for the population adjacency matrix, the misclassification error, and the estimation error for the link probability matrix. It turns out that, under mild conditions, the randomized spectral clustering algorithms lead to the same theoretical bounds as those of the original spectral clustering algorithm. We also extend the results to degree-corrected stochastic block models. Numerical experiments support our theoretical findings and show the efficiency of randomized methods. A new R package called Rclust is developed and made available to the public.

Evaluation of the resistance of implemented cryptographic algorithms against SCA attacks, as well as detecting of SCA leakage sources at an early stage of the design process, is important for an efficient re-design of the implementation. Thus, effective SCA methods that do not depend on the key processed in the cryptographic operations are beneficially and can be a part of the efficient design methodology for implementing cryptographic approaches. In this work we compare two different methods that are used to analyse power traces of elliptic curve point multiplications. The first method the comparison to the mean is a simple method based on statistical analysis. The second one is K-means - the mostly used unsupervised machine learning algorithm for data clustering. The results of our early work showed that the machine learning algorithm was not superior to the simple approach. In this work we concentrate on the comparison of the attack results using both analysis methods with the goal to understand their benefits and drawbacks. Our results show that the comparison to the mean works properly only if the scalar processed during the attacked kP execution is balanced, i.e. if the number of '1' in the scalar k is about as high as the number of '0'. In contrast to this, K-means is effective also if the scalar is highly unbalanced. It is still effective even if the scalar k contains only a very small number of '0' bits.

3D delineation of anatomical structures is a cardinal goal in medical imaging analysis. Prior to deep learning, statistical shape models that imposed anatomical constraints and produced high quality surfaces were a core technology. Prior to deep learning, statistical shape models that imposed anatomical constraints and produced high quality surfaces were a core technology. Today fully-convolutional networks (FCNs), while dominant, do not offer these capabilities. We present deep implicit statistical shape models (DISSMs), a new approach to delineation that marries the representation power of convolutional neural networks (CNNs) with the robustness of SSMs. DISSMs use a deep implicit surface representation to produce a compact and descriptive shape latent space that permits statistical models of anatomical variance. To reliably fit anatomically plausible shapes to an image, we introduce a novel rigid and non-rigid pose estimation pipeline that is modelled as a Markov decision process(MDP). We outline a training regime that includes inverted episodic training and a deep realization of marginal space learning (MSL). Intra-dataset experiments on the task of pathological liver segmentation demonstrate that DISSMs can perform more robustly than three leading FCN models, including nnU-Net: reducing the mean Hausdorff distance (HD) by 7.7-14.3mm and improving the worst case Dice-Sorensen coefficient (DSC) by 1.2-2.3%. More critically, cross-dataset experiments on a dataset directly reflecting clinical deployment scenarios demonstrate that DISSMs improve the mean DSC and HD by 3.5-5.9% and 12.3-24.5mm, respectively, and the worst-case DSC by 5.4-7.3%. These improvements are over and above any benefits from representing delineations with high-quality surface.

Determining the adsorption isotherms is an issue of significant importance in preparative chromatography. A modern technique for estimating adsorption isotherms is to solve an inverse problem so that the simulated batch separation coincides with actual experimental results. However, due to the ill-posedness, the high non-linearity, and the uncertainty quantification of the corresponding physical model, the existing deterministic inversion methods are usually inefficient in real-world applications. To overcome these difficulties and study the uncertainties of the adsorption-isotherm parameters, in this work, based on the Bayesian sampling framework, we propose a statistical approach for estimating the adsorption isotherms in various chromatography systems. Two modified Markov chain Monte Carlo algorithms are developed for a numerical realization of our statistical approach. Numerical experiments with both synthetic and real data are conducted and described to show the efficiency of the proposed new method.

Training datasets for machine learning often have some form of missingness. For example, to learn a model for deciding whom to give a loan, the available training data includes individuals who were given a loan in the past, but not those who were not. This missingness, if ignored, nullifies any fairness guarantee of the training procedure when the model is deployed. Using causal graphs, we characterize the missingness mechanisms in different real-world scenarios. We show conditions under which various distributions, used in popular fairness algorithms, can or can not be recovered from the training data. Our theoretical results imply that many of these algorithms can not guarantee fairness in practice. Modeling missingness also helps to identify correct design principles for fair algorithms. For example, in multi-stage settings where decisions are made in multiple screening rounds, we use our framework to derive the minimal distributions required to design a fair algorithm. Our proposed algorithm decentralizes the decision-making process and still achieves similar performance to the optimal algorithm that requires centralization and non-recoverable distributions.

Causal inference is a critical research topic across many domains, such as statistics, computer science, education, public policy and economics, for decades. Nowadays, estimating causal effect from observational data has become an appealing research direction owing to the large amount of available data and low budget requirement, compared with randomized controlled trials. Embraced with the rapidly developed machine learning area, various causal effect estimation methods for observational data have sprung up. In this survey, we provide a comprehensive review of causal inference methods under the potential outcome framework, one of the well known causal inference framework. The methods are divided into two categories depending on whether they require all three assumptions of the potential outcome framework or not. For each category, both the traditional statistical methods and the recent machine learning enhanced methods are discussed and compared. The plausible applications of these methods are also presented, including the applications in advertising, recommendation, medicine and so on. Moreover, the commonly used benchmark datasets as well as the open-source codes are also summarized, which facilitate researchers and practitioners to explore, evaluate and apply the causal inference methods.