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Multiple imputation (MI) models can be improved by including auxiliary covariates (AC), but their performance in high-dimensional data is not well understood. We aimed to develop and compare high-dimensional MI (HDMI) approaches using structured and natural language processing (NLP)-derived AC in studies with partially observed confounders. We conducted a plasmode simulation study using data from opioid vs. non-steroidal anti-inflammatory drug (NSAID) initiators (X) with observed serum creatinine labs (Z2) and time-to-acute kidney injury as outcome. We simulated 100 cohorts with a null treatment effect, including X, Z2, atrial fibrillation (U), and 13 other investigator-derived confounders (Z1) in the outcome generation. We then imposed missingness (MZ2) on 50% of Z2 measurements as a function of Z2 and U and created different HDMI candidate AC using structured and NLP-derived features. We mimicked scenarios where U was unobserved by omitting it from all AC candidate sets. Using LASSO, we data-adaptively selected HDMI covariates associated with Z2 and MZ2 for MI, and with U to include in propensity score models. The treatment effect was estimated following propensity score matching in MI datasets and we benchmarked HDMI approaches against a baseline imputation and complete case analysis with Z1 only. HDMI using claims data showed the lowest bias (0.072). Combining claims and sentence embeddings led to an improvement in the efficiency displaying the lowest root-mean-squared-error (0.173) and coverage (94%). NLP-derived AC alone did not perform better than baseline MI. HDMI approaches may decrease bias in studies with partially observed confounders where missingness depends on unobserved factors.

We study the use of local consistency methods as reductions between constraint satisfaction problems (CSPs), and promise version thereof, with the aim to classify these reductions in a similar way as the algebraic approach classifies gadget reductions between CSPs. This research is motivated by the requirement of more expressive reductions in the scope of promise CSPs. While gadget reductions are enough to provide all necessary hardness in the scope of (finite domain) non-promise CSP, in promise CSPs a wider class of reductions needs to be used. We provide a general framework of reductions, which we call consistency reductions, that covers most (if not all) reductions recently used for proving NP-hardness of promise CSPs. We prove some basic properties of these reductions, and provide the first steps towards understanding the power of consistency reductions by characterizing a fragment associated to arc-consistency in terms of polymorphisms of the template. In addition to showing hardness, consistency reductions can also be used to provide feasible algorithms by reducing to a fixed tractable (promise) CSP, for example, to solving systems of affine equations. In this direction, among other results, we describe the well-known Sherali-Adams hierarchy for CSP in terms of a consistency reduction to linear programming.

Deep neural network models for image segmentation can be a powerful tool for the automation of motor claims handling processes in the insurance industry. A crucial aspect is the reliability of the model outputs when facing adverse conditions, such as low quality photos taken by claimants to document damages. We explore the use of a meta-classification model to empirically assess the precision of segments predicted by a model trained for the semantic segmentation of car body parts. Different sets of features correlated with the quality of a segment are compared, and an AUROC score of 0.915 is achieved for distinguishing between high- and low-quality segments. By removing low-quality segments, the average mIoU of the segmentation output is improved by 16 percentage points and the number of wrongly predicted segments is reduced by 77%.

This paper studies linear reconstruction of partially observed functional data which are recorded on a discrete grid. We propose a novel estimation approach based on approximate factor models with increasing rank taking into account potential covariate information. Whereas alternative reconstruction procedures commonly involve some preliminary smoothing, our method separates the signal from noise and reconstructs missing fragments at once. We establish uniform convergence rates of our estimator and introduce a new method for constructing simultaneous prediction bands for the missing trajectories. A simulation study examines the performance of the proposed methods in finite samples. Finally, a real data application of temperature curves demonstrates that our theory provides a simple and effective method to recover missing fragments.

Building upon recent works on linesearch-free adaptive proximal gradient methods, this paper proposes adaPG$^{q,r}$, a framework that unifies and extends existing results by providing larger stepsize policies and improved lower bounds. Different choices of the parameters $q$ and $r$ are discussed and the efficacy of the resulting methods is demonstrated through numerical simulations. In an attempt to better understand the underlying theory, its convergence is established in a more general setting that allows for time-varying parameters. Finally, an adaptive alternating minimization algorithm is presented by exploring the dual setting. This algorithm not only incorporates additional adaptivity, but also expands its applicability beyond standard strongly convex settings.

The Lamport diagram is a pervasive and intuitive tool for informal reasoning about "happens-before" relationships in a concurrent system. However, traditional axiomatic formalizations of Lamport diagrams can be painful to work with in a mechanized setting like Agda. We propose an alternative, inductive formalization -- the causal separation diagram (CSD) -- that takes inspiration from string diagrams and concurrent separation logic, but enjoys a graphical syntax similar to Lamport diagrams. Critically, CSDs are based on the idea that causal relationships between events are witnessed by the paths that information follows between them. To that end, we model happens-before as a dependent type of paths between events. The inductive formulation of CSDs enables their interpretation into a variety of semantic domains. We demonstrate the interpretability of CSDs with a case study on properties of logical clocks, widely-used mechanisms for reifying causal relationships as data. We carry out this study by implementing a series of interpreters for CSDs, culminating in a generic proof of Lamport's clock condition that is parametric in a choice of clock. We instantiate this proof on Lamport's scalar clock, on Mattern's vector clock, and on the matrix clocks of Raynal et al. and of Wuu and Bernstein, yielding verified implementations of each. The CSD formalism and our case study are mechanized in the Agda proof assistant.

This paper addresses the problem of pathological lung segmentation, a significant challenge in medical image analysis, particularly pronounced in cases of peripheral opacities (severe fibrosis and consolidation) because of the textural similarity between lung tissue and surrounding areas. To overcome these challenges, this paper emphasizes the use of CycleGAN for unpaired image-to-image translation, in order to provide an augmentation method able to generate fake pathological images matching an existing ground truth. Although previous studies have employed CycleGAN, they often neglect the challenge of shape deformation, which is crucial for accurate medical image segmentation. Our work introduces an innovative strategy that incorporates additional loss functions. Specifically, it proposes an L1 loss based on the lung surrounding which shape is constrained to remain unchanged at the transition from the healthy to pathological domains. The lung surrounding is derived based on ground truth lung masks available in the healthy domain. Furthermore, preprocessing steps, such as cropping based on ribs/vertebra locations, are applied to refine the input for the CycleGAN, ensuring that the network focus on the lung region. This is essential to avoid extraneous biases, such as the zoom effect bias, which can divert attention from the main task. The method is applied to enhance in semi-supervised manner the lung segmentation process by employing a U-Net model trained with on-the-fly data augmentation incorporating synthetic pathological tissues generated by the CycleGAN model. Preliminary results from this research demonstrate significant qualitative and quantitative improvements, setting a new benchmark in the field of pathological lung segmentation. Our code is available at //github.com/noureddinekhiati/Semi-supervised-lung-segmentation

In many modern regression applications, the response consists of multiple categorical random variables whose probability mass is a function of a common set of predictors. In this article, we propose a new method for modeling such a probability mass function in settings where the number of response variables, the number of categories per response, and the dimension of the predictor are large. Our method relies on a functional probability tensor decomposition: a decomposition of a tensor-valued function such that its range is a restricted set of low-rank probability tensors. This decomposition is motivated by the connection between the conditional independence of responses, or lack thereof, and their probability tensor rank. We show that the model implied by such a low-rank functional probability tensor decomposition can be interpreted in terms of a mixture of regressions and can thus be fit using maximum likelihood. We derive an efficient and scalable penalized expectation maximization algorithm to fit this model and examine its statistical properties. We demonstrate the encouraging performance of our method through both simulation studies and an application to modeling the functional classes of genes.

This paper presents an analysis of properties of two hybrid discretization methods for Gaussian derivatives, based on convolutions with either the normalized sampled Gaussian kernel or the integrated Gaussian kernel followed by central differences. The motivation for studying these discretization methods is that in situations when multiple spatial derivatives of different order are needed at the same scale level, they can be computed significantly more efficiently compared to more direct derivative approximations based on explicit convolutions with either sampled Gaussian kernels or integrated Gaussian kernels. While these computational benefits do also hold for the genuinely discrete approach for computing discrete analogues of Gaussian derivatives, based on convolution with the discrete analogue of the Gaussian kernel followed by central differences, the underlying mathematical primitives for the discrete analogue of the Gaussian kernel, in terms of modified Bessel functions of integer order, may not be available in certain frameworks for image processing, such as when performing deep learning based on scale-parameterized filters in terms of Gaussian derivatives, with learning of the scale levels. In this paper, we present a characterization of the properties of these hybrid discretization methods, in terms of quantitative performance measures concerning the amount of spatial smoothing that they imply, as well as the relative consistency of scale estimates obtained from scale-invariant feature detectors with automatic scale selection, with an emphasis on the behaviour for very small values of the scale parameter, which may differ significantly from corresponding results obtained from the fully continuous scale-space theory, as well as between different types of discretization methods.

This paper explores variants of the subspace iteration algorithm for computing approximate invariant subspaces. The standard subspace iteration approach is revisited and new variants that exploit gradient-type techniques combined with a Grassmann manifold viewpoint are developed. A gradient method as well as a nonlinear conjugate gradient technique are described. Convergence of the gradient-based algorithm is analyzed and a few numerical experiments are reported, indicating that the proposed algorithms are sometimes superior to standard algorithms. This includes the Chebyshev-based subspace iteration and the locally optimal block conjugate gradient method, when compared in terms of number of matrix vector products and computational time, resp. The new methods, on the other hand, do not require estimating optimal parameters. An important contribution of this paper to achieve this good performance is the accurate and efficient implementation of an exact line search. In addition, new convergence proofs are presented for the non-accelerated gradient method that includes a locally exponential convergence if started in a $\mathcal{O(\sqrt{\delta})}$ neighbourhood of the dominant subspace with spectral gap $\delta$.